Reversible Cerebellar Ataxia Related to Extrapontine Myelinolysis without Hyponatremia after Cisplatin-Based Chemotherapy for Cholangiocarcinoma
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A 60-year-old woman presented with cerebellar signs including dysarthria and ataxia,after intravenous infusion of cisplatin-based chemotherapy. Several blood testsshowed mild neutropenia, normocytic normochromic anemia, but no evidence of amarked hyponatremia. Brain magnetic resonance imaging with diffusion-weightedsequences showed hyper-intense signal abnormalities in the extrapontine region,sparing the basis pontis. Here, we report on the case of a patient with reversiblecerebellar ataxia related to extrapontine myelinolysis without hyponatremia aftertreatment with cisplatin-based chemotherapy for cholangiocarcinoma and discussthe literature on cerebellar ataxia in patients who underwent recent chemotherapyfor malignancy.
Abstract
A 60-year-old woman presented with cerebellar signs including dysarthria and ataxia,after intravenous infusion of cisplatin-based chemotherapy. Several blood testsshowed mild neutropenia, normocytic normochromic anemia, but no evidence of amarked hyponatremia. Brain magnetic resonance imaging with diffusion-weightedsequences showed hyper-intense signal abnormalities in the extrapontine region,sparing the basis pontis. Here, we report on the case of a patient with reversiblecerebellar ataxia related to extrapontine myelinolysis without hyponatremia aftertreatment with cisplatin-based chemotherapy for cholangiocarcinoma and discussthe literature on cerebellar ataxia in patients who underwent recent chemotherapyfor malignancy.
참고문헌 (13)
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