The histometric analysis of osseointegration in hydroxyapatite surface dental implants by ion beam-assisted deposition
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Purpose: This study compared the effects of coating implants with hydroxyapatite (HA) using an ion beam-assisted deposition (IBAD) method prepared with machined, anodized, sandblasted and large-grit acid etched (SLA) surfaces in minipigs, and verified the excellency of coating method with HA using IBAD. Material and Methods: 4 male Minipigs(Prestige World Genetics, Korea), 18 to 24 months old and weighing approximately 35 to 40 kg, were chosen. All premolars and first molars of the maxilla were carefully extracted on each side. The implants were placed on the right side after an 8 week healing period. The implant stability was assessed by resonance frequency analysis (RFA) at the time of placement. 40 implants were divided into 5 groups; machined, anodized, anodized plus IBAD, SLA, and SLA plus IBAD surface implants. 4 weeks after implantation on the right side, the same surface implants were placed on the left side. After 4 weeks of healing, the minipigs were sacrificed and the implants were analyzed by RFA, histology and histometric. Results: RFA showed a mean implant stability quotient (ISQ) of 75.625±5.021, 76.125± 3.739 ISQ and 77.941±2.947 at placement, after 4 weeks healing and after 8 weeks, respectively. Histological analysis of the implants demonstrated newly formed, compact, mature cortical bone with a nearby marrow spaces. HA coating was not separated from the HA coated implant surfaces using IBAD. In particular, the SLA implants coated with HA using IBAD showed better contact osteogenesis. Statistical and histometric analysis showed no significant differences in the bone to implant contact and bone density among 5 tested surfaces. Conclusion: We can conclude that rough surface implants coated with HA by IBAD are more biocompatible, and clinical, histological, and histometric analysis showed no differences when compared with the other established implant surfaces in normal bone. (J Korean Acad Periodontol 2008;38:363-372) KEY WORDS: Ion beam-assisted deposition method; hydroxyapatite;
Abstract
Purpose: This study compared the effects of coating implants with hydroxyapatite (HA) using an ion beam-assisted deposition (IBAD) method prepared with machined, anodized, sandblasted and large-grit acid etched (SLA) surfaces in minipigs, and verified the excellency of coating method with HA using IBAD. Material and Methods: 4 male Minipigs(Prestige World Genetics, Korea), 18 to 24 months old and weighing approximately 35 to 40 kg, were chosen. All premolars and first molars of the maxilla were carefully extracted on each side. The implants were placed on the right side after an 8 week healing period. The implant stability was assessed by resonance frequency analysis (RFA) at the time of placement. 40 implants were divided into 5 groups; machined, anodized, anodized plus IBAD, SLA, and SLA plus IBAD surface implants. 4 weeks after implantation on the right side, the same surface implants were placed on the left side. After 4 weeks of healing, the minipigs were sacrificed and the implants were analyzed by RFA, histology and histometric. Results: RFA showed a mean implant stability quotient (ISQ) of 75.625±5.021, 76.125± 3.739 ISQ and 77.941±2.947 at placement, after 4 weeks healing and after 8 weeks, respectively. Histological analysis of the implants demonstrated newly formed, compact, mature cortical bone with a nearby marrow spaces. HA coating was not separated from the HA coated implant surfaces using IBAD. In particular, the SLA implants coated with HA using IBAD showed better contact osteogenesis. Statistical and histometric analysis showed no significant differences in the bone to implant contact and bone density among 5 tested surfaces. Conclusion: We can conclude that rough surface implants coated with HA by IBAD are more biocompatible, and clinical, histological, and histometric analysis showed no differences when compared with the other established implant surfaces in normal bone. (J Korean Acad Periodontol 2008;38:363-372) KEY WORDS: Ion beam-assisted deposition method; hydroxyapatite;
참고문헌 (26)
- Albrektsson, T, "Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man", Acta Orthopedica Scandinavica, 52, pp.155~170 (1981)
- Bornstein, MM, "Early loading of titanium implants with a sandblasted and acid-etched (SLA) surface. 3-year results of a prospective study in partially edentulous patients", International Journal of Oral & Maxillofacial Implants, 18, pp.659~666 (2003)
- Buser, D, "Titanium for dental applications (II): implants with roughened surfaces. In: Titanium in medicine", pp.876~888 (2001), Springer
- Buser, D, "Enhanced bone apposition to a chemically modified SLA titanium surface", Journal of Dental Research, 83, pp.529~533 (2004)
- Buser, D, "Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs", Journal of Biomedical Materials Research, 25, pp.889~902 (1999)
- Cochran, Buser, D, "The use of reduced healing times on ITI implants with a sandblasted and acid-etched (SLA) surface: early results from clinical trials on ITI SLA implants", Clinical Oral Implants Research, 13, pp.144~153 (2002)
- Cochran, DL, "Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible", Journal of Biomedical Materials Research, 40, pp.1~11 (1998)
- Comut, AA, "Connective tissue orientation around dental implants in a canine model", Clinical Oral Implants Research, 12, pp.433~440 (2001)
- Cook, SD, "Interface mechanics and histology of titanium and hydroxyapatite-coated titanium for dental implant applications", International Journal of Oral & Maxillofacial Implants, 2, pp.15~22 (1987)
- Cui, FZ, "Highly adhesive hydroxyapatite coatings on titanium alloy formed by ion beam assisted deposition", Journal of Materials Science. Materials in Medicine, 8, pp.403~405 (1997)
- Friedman, RJ, "Current concepts in orthopaedic biomaterial and implant fixation", Instructional course lectures, 43, pp.233~255 (1994)
- Lazzara, RJ, "A prospective multicenter study evaluating loading of osseotite implants two months after placement: one-year results", Journal of Esthetic Dentistry, 10, pp.280~289 (1998)
- Lee, IS, "Studies on calcium phosphate coating", Surface and Coating Technology, 131, pp.181~186 (2000)
- Lee, IS, "Various Ca", P ratios of thin calcium phosphate films, 2002, pp.C22, 15~20
- Lee, IS, "Effects of ion beam assist on the formation of calcium phosphate film", Nuclear instruments and methods in Physics Research, B206, pp.522~526 (2003)
- Li, D, "Biomechanical comparison of the sandblasted and acid-etched and the machined and acid-etched titanium surface for dental implants", Journal of Biomedical Materials Research, 60, pp.325~332 (2002)
- Liu, JQ, "High-resolution transmission electron microscopy investigations of a highly adhesive hydroxyapatite coating", titanium interface fabricated by ion-beam-assisted deposition, 2000, pp.52, 115~118
- Nkenke, E, "Immediate versus delayed loading of dental implants in the maxillae of minipigs: follow-up of implant stability and implant failures", International Journal of Oral & Maxillofacial Implants, 20, pp.39~47 (2005)
- Nkenke, E, "Bone contact, growth, and density around immediately loaded implants in the mandible of mini pigs", Clinical Oral Implants Research, 14, pp.312~321 (2003)
- Park, YS, "The effects of ion beam-assisted deposition of hydroxyapatite on the grit-blasted surface of endosseous implants in rabbit tibiae", International Journal of Oral & Maxillofacial Implants, 20, pp.31~38 (2005)
- Roccuzzo, M, "Early loading of sandblasted and acid-etched (SLA) implants: a prospective split-mouth comparative study", Clinical Oral Implants Research, 12, pp.572~578 (2001)
- Sodek, J, "Molecular regulation of osteogenesis. In: Bone engineering", pp.31~43 (2000)
- Van, DK, "Influence of discharge power level on the properties of hydroxyapatite films deposited on Ti6Al4V with RF magnetron sputtering", Journal of Biomedical Materials Research, pp.269~276 (1995)
- Wilke, HJ, "The influence of various titanium surfaces on the interface shear strength between implants and bone. In: Clinical implant materials", Adv Biomater, 9, pp.309~314 (1990)
- Zhao, BH, "Microcosmic analysis of TCP", HA coating with micro-pores on titanium by IBAD method, 2004, pp.13, 385~388
- Kim HG, "The biocompatibility of SLA-treated", Titanium implants Biomedical materials, 3, pp.1~6 (2008)