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Stem cell therapy in pain medicine

Kyung Hoon Kim|Salahadin Abdi|Yong Hee Han|Tae Kyun Kim
대한통증학회 (The Korean Pain Society)|2019.10|The Korean Journal of Pain|제32권 제4호|pp. 245-255|DOI 10.3344/kjp.2019.32.4.245

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초록

Stem cells are attracting attention as a key element in future medicine, satisfying the desire to live a healthier life with the possibility that they can regenerate tissue damaged or degenerated by disease or aging. Stem cells are defined as undifferentiated cells that have the ability to replicate and differentiate themselves into various tissues cells. Stem cells, commonly encountered in clinical or preclinical stages, are largely classified into embryonic, adult, and induced pluripotent stem cells. Recently, stem cell transplantation has been frequently applied to the treatment of pain as an alternative or promising approach for the treatment of severe osteoarthritis, neuropathic pain, and intractable musculoskeletal pain which do not respond to conventional medicine. The main idea of applying stem cells to neuropathic pain is based on the ability of stem cells to release neurotrophic factors, along with providing a cellular source for replacing the injured neural cells, making them ideal candidates for modulating and possibly reversing intractable neuropathic pain. Even though various differentiation capacities of stem cells are reported, there is not enough knowledge and technique to control the differentiation into desired tissues in vivo. Even though the use of stem cells is still in the very early stages of clinical use and raises complicated ethical problems, the future of stem cells therapies is very bright with the help of accumulating evidence and technology.

Abstract

Stem cells are attracting attention as a key element in future medicine, satisfying the desire to live a healthier life with the possibility that they can regenerate tissue damaged or degenerated by disease or aging. Stem cells are defined as undifferentiated cells that have the ability to replicate and differentiate themselves into various tissues cells. Stem cells, commonly encountered in clinical or preclinical stages, are largely classified into embryonic, adult, and induced pluripotent stem cells. Recently, stem cell transplantation has been frequently applied to the treatment of pain as an alternative or promising approach for the treatment of severe osteoarthritis, neuropathic pain, and intractable musculoskeletal pain which do not respond to conventional medicine. The main idea of applying stem cells to neuropathic pain is based on the ability of stem cells to release neurotrophic factors, along with providing a cellular source for replacing the injured neural cells, making them ideal candidates for modulating and possibly reversing intractable neuropathic pain. Even though various differentiation capacities of stem cells are reported, there is not enough knowledge and technique to control the differentiation into desired tissues in vivo. Even though the use of stem cells is still in the very early stages of clinical use and raises complicated ethical problems, the future of stem cells therapies is very bright with the help of accumulating evidence and technology.

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관련 논문AI추천

줄기세포를 이용한 골관절염 치료남유준, 임예리, 주지현대한내과학회 · 대한내과학회지2019 · 제94권 제2호Current perspectives in stem cell therapies for osteoarthritis of the knee김기범, 손욱진영남대학교 의과대학 · Journal of Yeungnam Medical Science2020 · 제37권 제3호The effect of human mesenchymal stem cell injection on pain behavior in chronic post-ischemia pain mice유시현, Heecheol Jin, Hue Jung Park, Jae Hong Park, Seunghwan Lee, Seunghyeon Lee, Sung Hyun Lee대한통증학회 · The Korean Journal of Pain2020 · 제33권 제1호Intrathecal Administration of Mesenchymal Stem Cells Reduces the Reactive Oxygen Species and Pain Behavior in Neuropathic Rats고영권, 송창화, 이원형, ZHANGENJI대한통증학회 · The Korean Journal of Pain2014 · 제27권 제3호The efficacy of GABAergic precursor cells transplantation in alleviating neuropathic pain in animal models: a systematic review and meta-analysisAmirmohammad Toloui, Arash Sarveazad, Arian Madani Neishaboori, Mahmoud Yousefifard, Mohammed I. M. Gubari, Mostafa Hosseini, Seyedeh Niloufar Rafiei Alavi, Shaghayegh Askarian-Amiri, Solmaz Nasseri Maleki대한통증학회 · The Korean Journal of Pain2022 · 제35권 제1호Intra-Articular Injection of Bone Marrow-Derived Mesenchymal Stem Cells Leading to Better Clinical Outcomes without Difference in MRI Outcomes from Baseline in Patients with Knee Osteoarthritis김희선, 이선희, Jung Ro Yoon, Young­Soo Shin대한슬관절학회 · Knee Surgery and Related Research2018 · 제30권 제3호

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