Intra-Articular Injection of Bone Marrow-Derived Mesenchymal Stem Cells Leading to Better Clinical Outcomes without Difference in MRI Outcomes from Baseline in Patients with Knee Osteoarthritis
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Purpose: Bone marrow (BM) is frequently used as a source of mesenchymal stem cells (MSCs) because they have a high potential for differentiation. However, it is unclear whether BMderived MSCs lead to better clinical and magnetic resonance imaging (MRI) outcomes postoperatively. Materials and Methods: This metaanalysis compared the clinical and MRI outcomes in patients with knee osteoarthritis (OA) treated with BMderived MSCs. Eight studies comparing the clinical and MRI outcomes assessed with various measurement tools in patients with knee OA treated with BMderived MSCs were included. Results: The range of motion (95% confidence interval [CI], –13.05 to 4.24; p=0.32) and MRI outcomes (95% CI, –0.16 to 1.40; p=0.12) did not differ significantly between the baseline and final followup. In contrast, pain (95% CI, 0.89 to 1.87; p<0.001) and functional outcomes (95% CI, 0.70 to 2.07; p<0.001) were significantly improved at the final followup when compared to the baseline.Conclusions: This metaanalysis found no significant difference in the tested range of motion and MRI outcomes between the baseline and the final followup in patients treated with BMderived MSCs, whereas significant functional improvement and pain relief were noted when compared with the baseline. Thus, BMderived MSCs appear to be a viable alternative for patients with knee OA, although longterm and highquality randomized controlled trials are needed to confirm the clinical benefits.
Abstract
Purpose: Bone marrow (BM) is frequently used as a source of mesenchymal stem cells (MSCs) because they have a high potential for differentiation. However, it is unclear whether BMderived MSCs lead to better clinical and magnetic resonance imaging (MRI) outcomes postoperatively. Materials and Methods: This metaanalysis compared the clinical and MRI outcomes in patients with knee osteoarthritis (OA) treated with BMderived MSCs. Eight studies comparing the clinical and MRI outcomes assessed with various measurement tools in patients with knee OA treated with BMderived MSCs were included. Results: The range of motion (95% confidence interval [CI], –13.05 to 4.24; p=0.32) and MRI outcomes (95% CI, –0.16 to 1.40; p=0.12) did not differ significantly between the baseline and final followup. In contrast, pain (95% CI, 0.89 to 1.87; p<0.001) and functional outcomes (95% CI, 0.70 to 2.07; p<0.001) were significantly improved at the final followup when compared to the baseline.Conclusions: This metaanalysis found no significant difference in the tested range of motion and MRI outcomes between the baseline and the final followup in patients treated with BMderived MSCs, whereas significant functional improvement and pain relief were noted when compared with the baseline. Thus, BMderived MSCs appear to be a viable alternative for patients with knee OA, although longterm and highquality randomized controlled trials are needed to confirm the clinical benefits.
참고문헌 (29)
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