Tomographic and histometric analysis of autogenous bone block and synthetic hydroxyapatite block grafts without rigid fixation on rabbit calvaria
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Purpose: The preferred material for bone augmentation beyond the envelope of skeletalbone is the bone block graft, due to its dimensional stability. We evaluated the necessity ofrigid fixation for the bone block graft, and compared the bone regeneration and volumemaintenance associated with grafting using a synthetic hydroxyapatite block (HAB) and anautogenous bone block (ABB) without rigid fixation on rabbit calvaria over two differentperiods. Methods: Cylinder-shaped synthetic HAB and ABB were positioned without fixation on therabbit calvarium (n=16). The animals were sacrificed at 4 or 8 weeks postoperatively, andthe grafted materials were analyzed at each healing period using microcomputed tomographyand histologic evaluation. Results: Integration of the graft and the recipient bed was observed in all specimens, althoughminor dislocation of the graft materials from the original position was evident insome specimens (six ABB and ten HAB samples). A tendency toward progressive bone resorptionwas observed in the grafted ABB but not in the grafted HAB, which maintained anintact appearance. In the HAB group, the area of new bone increased between 4 and 8weeks postoperatively, but the difference was not statistically significant. Conclusions: The nonfixed HAB was successfully integrated into the recipient bed afterboth healing periods in the rabbit calvaria. In spite of limited bone formation activity incomparison to ABB, HAB may be a favorable substitute osteoconductive bone material.
Abstract
Purpose: The preferred material for bone augmentation beyond the envelope of skeletalbone is the bone block graft, due to its dimensional stability. We evaluated the necessity ofrigid fixation for the bone block graft, and compared the bone regeneration and volumemaintenance associated with grafting using a synthetic hydroxyapatite block (HAB) and anautogenous bone block (ABB) without rigid fixation on rabbit calvaria over two differentperiods. Methods: Cylinder-shaped synthetic HAB and ABB were positioned without fixation on therabbit calvarium (n=16). The animals were sacrificed at 4 or 8 weeks postoperatively, andthe grafted materials were analyzed at each healing period using microcomputed tomographyand histologic evaluation. Results: Integration of the graft and the recipient bed was observed in all specimens, althoughminor dislocation of the graft materials from the original position was evident insome specimens (six ABB and ten HAB samples). A tendency toward progressive bone resorptionwas observed in the grafted ABB but not in the grafted HAB, which maintained anintact appearance. In the HAB group, the area of new bone increased between 4 and 8weeks postoperatively, but the difference was not statistically significant. Conclusions: The nonfixed HAB was successfully integrated into the recipient bed afterboth healing periods in the rabbit calvaria. In spite of limited bone formation activity incomparison to ABB, HAB may be a favorable substitute osteoconductive bone material.
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