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Mineral trioxide aggregate (MTA)가 치주인대 섬유아세포에서 분비되는 cytokine과 성장인자 TGF- β1, FGF-2 발현에 미치는 영향

The effect of mineral trioxide aggregate on the production of growth factors and cytokine by human periodontal ligament fibroblasts

백승호|권지윤|배광식|이우철|임성삼|강명회
대한치과보존학회 (Korean Academy Of Conservative Dentistry)|2007.05|Restorative Dentistry and Endodontics|제32권 제3호|pp. 191-197

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Abstract

tion of periodontium - alveolar bone, periodontalligament and cementum5-7). Furthermore, it is amaterial on which the cells can keep their healthystates, grow well and obtain firm attachment8-11).For these reasons, MTA is the material of choicewhen the root-end filling material is indicated. Many biologic molecules get involved in woundhealing process by several mechanisms. Growthfactors and cytokines are mediator molecules thathave important roles in tissue development andrepair.12,13) Among the mediator molecules, trans-forming growth factor-beta1 (TGF-β 1), fibroblastgrowth factor-2 (FGF-2), and cytokine inter-leukin-6 (IL-6) are one of the critical factors.TGF-β1 is known to be related to the mitogenesisof cells and the remodeling of extracellularmatrix12,14) while FGF-2 has a potent angiogeniceffect15). IL-6 is one of the well-known and plenti-ful inflammatory cytokines16). In this regard, Koh et al.17) studied the cytokineproduction from osteoblastic cells in contact withMTA, and they found that MTA has an up-regu-lating effect on the expression of IL-1α , IL-1β,and IL-6 from osteoblasts. Among the cells that constitute the periapicaltissue, periodontal ligament (PDL) cells are oneof the most abundant and produce many kinds ofgrowth factors and cytokines18). Especially, PDLfibroblasts mainly exist in the periodontal liga-ments that encapsulate the cementum of the root,affect the maintenance and regeneration of theperiodontal tissue by regulating the turnover ofcollagen and alveolar bone remodeling, and con-tact directly with the sealing material when root-end filling procedure is performed

참고문헌 (30)

  1. "aretrospective success-failure study of amalgam", pp.391~393 (1990)
  2. "Pitt Ford TR. Sealing abilityof a mineral trioxide aggregate when used as a rootend filling material. J Endod 19", pp.591~595 (1993)
  3. "Leakage evaluation of root end filling materials using endotoxin", 28, pp.5~7 (2002)
  4. "Histologic assessment of mineral trioxide aggregate as a root-end filling in monkeys", 23, pp.225~228 (1997)
  5. "Tissue reaction to implanted root-end filling materials in the tibia and mandible of guinea pigs", 24, pp.468~171 (1998)
  6. "Short-term periradicular tissue response to mineral trioxide aggregate (MTA) as root-end filling material", 36, pp.44~48 (2003)
  7. "Cellular response to Mineral Trioxide Aggregate", 24, pp.543~547 (1998)
  8. "Osteoblast biocompatibility of mineral trioxide aggregate", 20, pp.167~173 (1999)
  9. "Attachment and morphological behavior ofhuman periodontal ligament fibroblasts to mineral tri-oxide aggregate: a scanning electron microscope study", 30, pp.25~29 (2004)
  10. "Cementoblasts maintain expression of osteocalcin inthe presence of mineral trioxide aggregate.", 29, pp.407~12 (2003)
  11. "The potential role of growth and differentiationfactors in periodontal regeneration.", 67, pp.545~553 (1996)
  12. "Biological mediators for periodontal andbone regeneration.", 23, pp.501~512 (2002)
  13. "Canalis E. Transforminggrowth factor beta is a bifunctional regulator of replicationand collagen synthesis in osteoblast-enrichedcell cultures from fetal rat bone. J Biol Chem 262", pp.2869~74 (1987)
  14. "Cytokine expression in periodontalhealth and disease.", 9, pp.248~266 (1998)
  15. "Autocrine growth factors in human periodontalligament cells cultured on enamel matrixderivative.", 28, pp.181~188 (2001)
  16. "Mineral trioxide aggregate stimulates a biological response in human osteoblasts", 37, pp.432~439 (1997)
  17. "Brunette DM. Formation ofnew periodontal ligament by periodontal ligament cellsimplanted in vivo after culture in vitro. A preliminarystudy of transplanted roots in the dog. J Periontal Res16", pp.73~88 (1981)
  18. "Melcher AH. On the repair potential of periodontal tissue.J Periodontol 62", pp.458~467 (1974)
  19. "Bordin S. Role of fibroblast subpopulationsin periodontal physiology and pathology. JPeriodont Res 26", pp.144~154 (1991)
  20. "Ellison RL. Osseous healingkinetics after picoectomy in monkeys. II. A quantitativehistologic appraisal. J Endod 11", pp.269~74 (1985)
  21. "Jurosky KA. Wound healing in the tissuesof the periodontium following periradicularsurgery. III. The osseous excisional wound. J Endod18", pp.76~81 (1992)
  22. "Comparisonof Diaket and MTA when used as root-end filling materialsto support regeneration of the periradicular tissues.", 35, pp.840~847 (2002)
  23. "Cytotoxicity of mineraltrioxide aggregate using human periodontal ligamentfibroblast.", 26, pp.288~291 (2000)
  24. "Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation.", 46, pp.3000~3009 (2002)
  25. "Graves DT. Study of the growth factorrequirements of human bone-derived cells", pp.131~8 (1989)
  26. "Roodman GD.Transforming growth factor beta inhibits formation ofosteoclast-like cells in long-term human marrow cultures.Proc Natl Acad Sci 85", pp.5683~7 (1988)
  27. "Platelet-rich plasmacontains high levels of platelet-derived growth factorand transforming growth factor-beta and modulatesthe proliferation of periodontally related cells in vitro.", 74, pp.849~857 (2003)
  28. "Effects of basicfibroblast growth factor on human periodontal ligamentcells.", 32, pp.667~675 (1997)
  29. "Effects of root-end filling materials onfibroblasts and macrophages in vitro. Oral Surg Oral", 95, pp.739~745 (2003)
  30. "Cellular response to mineral trioxide aggregate.", 24, pp.543~547 (1998)

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