The effects of regular exercise on capsaicin-induced pulpal pain and pain-induced changes in passive avoidance learning and memory in rats
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Background: Pulpal pain is one of the most common and severe orofacial pain conditions with considerable adverse effects on physiological processes including learning and memory. Regular exercise is known to be effective on cognitive function as well as pain processing in the central nervous system. Here, the possible effects of regular exercise on pulpal pain response as well as pain-induced changes in learning and memory efficiency in rats were investigated.Methods: Twenty-four male Wistar rats were randomly assigned to the control, capsaicin, exercise, and exercise plus capsaicin groups. Rats in exercise groups were forced to run on a treadmill with a moderate exercise protocol for 4 weeks. Capsaicin was used to induce dental pulp pain. Passive avoidance learning and memory performance was assessed by using a shuttle box apparatus.Results: According to the results, regular exercise could decrease the time course of capsaicin-induced pulpal pain (P < 0.001). Moreover, in capsaicin-treated rats, passive avoidance acquisition was impaired as compared to the control (P < 0.05) and exercise (P < 0.001) groups. Additionally, regular exercise before capsaicin injection could attenuate capsaicin-induced memory impairments (P < 0.05).Conclusions: Taken together, the present data showed that regular exercise has inhibitory effects on capsaicin-induced pulpal pain as well as pain-induced cognitive dysfunction in rats. (Korean J Pain 2017; 30: 258-64)
Abstract
Background: Pulpal pain is one of the most common and severe orofacial pain conditions with considerable adverse effects on physiological processes including learning and memory. Regular exercise is known to be effective on cognitive function as well as pain processing in the central nervous system. Here, the possible effects of regular exercise on pulpal pain response as well as pain-induced changes in learning and memory efficiency in rats were investigated.Methods: Twenty-four male Wistar rats were randomly assigned to the control, capsaicin, exercise, and exercise plus capsaicin groups. Rats in exercise groups were forced to run on a treadmill with a moderate exercise protocol for 4 weeks. Capsaicin was used to induce dental pulp pain. Passive avoidance learning and memory performance was assessed by using a shuttle box apparatus.Results: According to the results, regular exercise could decrease the time course of capsaicin-induced pulpal pain (P < 0.001). Moreover, in capsaicin-treated rats, passive avoidance acquisition was impaired as compared to the control (P < 0.05) and exercise (P < 0.001) groups. Additionally, regular exercise before capsaicin injection could attenuate capsaicin-induced memory impairments (P < 0.05).Conclusions: Taken together, the present data showed that regular exercise has inhibitory effects on capsaicin-induced pulpal pain as well as pain-induced cognitive dysfunction in rats. (Korean J Pain 2017; 30: 258-64)
참고문헌 (46)
- Lipton JA, "Estimated prevalence and distribution of reported orofacial pain in the United States", J Am Dent Assoc, 124(10), pp.115~121 (1993)
- Geurts JW, "Multidisciplinary treatment of orofacial pain", Ned Tijdschr Tandheelkd, 123, pp.547~551 (2016)
- Sessle BJ, "Neural mechanisms and pathways in craniofacial pain", Can J Neurol Sci, 26(Suppl 3), pp.S7~S11 (1999)
- Venkatachalam K, "TRP channels", Annu Rev Biochem, 76, pp.387~417 (2007)
- Huang J, "Inflammatory pain : the cellular basis of heat hyperalgesia", Curr Neuropharmacol, 4, pp.197~206 (2006)
- Petersen LJ, "No release of histamine and substance P in capsaicin-induced neurogenic inflammation in intact human skin in vivo : a microdialysis study", Clin Exp Allergy, 27, pp.957~965 (1997)
- Nahman-Averbuch H, "Pain modulation and autonomic function: the effect of clonidine", Pain Med (2016)
- Moriarty O, "The effect of pain on cognitive function : a review of clinical and preclinical research", Prog Neurobiol, 93, pp.385~404 (2011)
- Raoof R, "Changes in hippocampal orexin 1 receptor expression involved in tooth pain-induced learning and memory impairment in rats", Neuropeptides, 50, pp.9~16 (2015)
- Kooshki R, "The role of trigeminal nucleus caudalis orexin 1 receptors in orofacial pain transmission and in orofacial pain-induced learning and memory impairment in rats", Physiol Behav, 157, pp.20~27 (2016)
- Williamson DJ, "Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat", Cephalalgia, 17, pp.518~524 (1997)
- Parise M, "Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia", J Headache Pain, 15, pp.17~ (2014)
- Wu Z, "Trigeminal neuralgia induced by cobra venom in the rat leads to deficits in abilities of spatial learning and memory", Pain Physician, 18, pp.E207~E216 (2015)
- Weissman-Fogel I, "Abnormal cortical activity in patients with temporomandibular disorder evoked by cognitive and emotional tasks", Pain, 152, pp.384~396 (2011)
- Hillman CH, "Be smart, exercise your heart: exercise effects on brain and cognition", Nat Rev Neurosci, 9, pp.58~65 (2008)
- Chang YK, "The effects of acute exercise on cognitive performance : a meta-analysis", Brain Res, 1453, pp.87~101 (2012)
- Radahmadi M, "Effect of exercise, exercise withdrawal, and continued regular exercise on excitability and long-term potentiation in the dentate gyrus of hippocampus", Brain Res, 1653, pp.8~13 (2016)
- Kandola A, "Aerobic exercise as a tool to improve hippocampal plasticity and function in humans : practical implications for mental health treatment", Front Hum Neurosci, 10, pp.373~ (2016)
- Subramaniapillai M, "The effect of an acute bout of exercise on executive function among individuals with schizophrenia", Psychiatry Res, 246, pp.637~643 (2016)
- Fuss J, "A runner’s high depends on cannabinoid receptors in mice", Proc Natl Acad Sci U S A, 112, pp.13105~13108 (2015)
- Stagg NJ, "Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model : role of endogenous opioids", Anesthesiology, 114, pp.940~948 (2011)
- 박수진, "다양한 운동 강도가 골관절염 흰쥐의 척수 내 TNF-α 발현에 미치는 영향", 대한물리의학회지, 8(4), pp.539~547 (2013), 대한물리의학회
- de Moura Guimarães T, "Mandibular exercises for the prevention of temporomandibular disorder during mandibular advancement device therapy in obstructive sleep apnea patients: a randomized controlled trial", Int Arch Med, 9 (2016)
- Calixtre LB, "Effects of cervical mobilization and exercise on pain, movement and function in subjects with temporomandibular disorders: a single group pre-post test", J Appl Oral Sci, 24, pp.188~197 (2016)
- Zagaar M, "The beneficial effects of regular exercise on cognition in REM sleep deprivation: behavioral, electrophysiological and molecular evidence", Neurobiol Dis, 45, pp.1153~1162 (2012)
- Jones DM, "Carbon dioxideinduced anesthesia has no effect on brain biogenic amine concentrations in mice", Lab Anim Sci, 49, pp.316~318 (1999)
- Kohler I, "Is carbon dioxide (CO2) a useful short acting anaesthetic for small laboratory animals?", Lab Anim, 33, pp.155~161 (1999)
- Pelissier T, "The orofacial capsaicin test in rats : effects of different capsaicin concentrations and morphine", Pain, 96, pp.81~87 (2002)
- Raoof M, "Noxious stimulation of the rat tooth pulp may impair learning and memory through the induction of hippocampal apoptosis", J Oral Facial Pain Headache, 29, pp.390~397 (2015)
- Chidiac JJ, "Nociceptive behaviour induced by dental application of irritants to rat incisors : a new model for tooth inflammatory pain", Eur J Pain, 6, pp.55~67 (2002)
- Hung CH, "Therapeutic ultrasound and treadmill training suppress peripheral nerve injury-induced pain in rats", Phys Ther, 96, pp.1545~1553 (2016)
- Loyd DR, "Sex differences in serotonin enhancement of capsaicin-evoked calcitonin gene-related peptide release from human dental pulp", Pain, 153, pp.2061~2067 (2012)
- Grace PM, "Pathological pain and the neuroimmune interface", Nat Rev Immunol, 14, pp.217~231 (2014)
- Leicht CA, "The physiology of exercise in spinal cord injury", pp.217~231 (2016), Springer
- Lee YY, "Exercise suppresses COX-2 pro-inflammatory pathway in vestibular migraine", Brain Res Bull, 116, pp.98~105 (2015)
- Koltyn KF, "Analgesia following exercise : a review", Sports Med, 29, pp.85~98 (2000)
- Bement MK, "Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner", Arch Phys Med Rehabil, 86, pp.1736~1740 (2005)
- Su CF, "Mediation of beta-endorphin in exercise-induced improvement in insulin resistance in obese Zucker rats", Diabetes Metab Res Rev, 21, pp.175~182 (2005)
- Dietrich A, "Endocannabinoids and exercise", Br J Sports Med, 38, pp.536~541 (2004)
- Bechara RG, "Exercise improves object recognition memory and induces BDNF expression and cell proliferation in cognitively enriched rats", Behav Brain Res, 245, pp.96~100 (2013)
- Sleiman SF, "Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body -hydroxybutyrate", Elife, 5, pp.e15092~ (2016)
- Erfanparast A, "Effects of intrahippocampal microinjection of vitamin B12 on the orofacial pain and memory impairments induced by scopolamine and orofacial pain in rats", Physiol Behav, 170, pp.68~77 (2017)
- Kim SE, "Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus", Exp Gerontol, 45, pp.357~365 (2010)
- Phaneuf S, "Apoptosis and exercise", Med Sci Sports Exerc, 33, pp.393~396 (2001)
- Esch T, "Endogenous reward mechanisms and their importance in stress reduction, exercise and the brain", Arch Med Sci, 6, pp.447~455 (2010)
- Greenwood BN, "Exercise, stress resistance, and central serotonergic systems", Exerc Sport Sci Rev, 39, pp.140~149 (2011)
