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Statistical notes for clinical researchers: the independent samples t-test

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The t-test is frequently used in comparing 2 group means. The compared groups may be independent to each other such as men and women. Otherwise, compared data are correlated in a case such as comparison of blood pressure levels from the same person before and after medication (Figure 1). In this section we will focus on independent t-test only. There are 2 kinds of independent t-test depending on whether 2 group variances can be assumed equal or not. The t-test is based on the inference using t-distribution.

Abstract

The t-test is frequently used in comparing 2 group means. The compared groups may be independent to each other such as men and women. Otherwise, compared data are correlated in a case such as comparison of blood pressure levels from the same person before and after medication (Figure 1). In this section we will focus on independent t-test only. There are 2 kinds of independent t-test depending on whether 2 group variances can be assumed equal or not. The t-test is based on the inference using t-distribution.

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