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자궁목의 선암종에서 인유두종 바이러스 16, 18 및 33형의 감염: p53유전자 돌연변이 및 임상병리학적 상관성 분석

Human Papillomavirus Type 16, 18, and 33 Infection in Adenocarcinoma of the Uterine Cervix: Analysis of the p53 Gene Mutation and the Clincopathologic Correlation

조성준|나선영|서광선|노흥태|남상륜
대한병리학회|2004.10|Journal of Pathology and Translational Medicine|제38권 제5호|pp. 295-300

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참고문헌

주제분류병리학

초록

Abstract

Background : Current evidence implicates specific types of the human papillomavirus (HPV) are involved in the development of cervical cancer. In HPV-negative cervical carcinomas, p53 mutation is thought to be a mechanism of oncogenesis. The purpose of this study was to evaluate the prevalence of p53 mutations in cervical adenocarcinomas and to investigate their correlation with HPV status and clinicopathologic parameters. Methods : A series of 38 primary cervical adenocarcinomas was analyzed for both HPV infection and p53 mutations. The HPV 16, 18, and 33 status was investigated by PCR amplification. The point mutations of the p53 gene were detected by the PCR-SSCP technique. Results : The prevalence of HPV 16, 18, or 33 infection was 73.7% (28/38). HPV 16 was present in 12 cases, HPV 18 was present in 15 cases, and HPV 33 was positive in one case. There was only one case that was positive for 18 as well as a p53 mutation in exon 6. Conclusions : Our results indicate that HPV 18 infection was more common in cervical adenocarcinomas than HPV 16 infection. Mutant p53 was rarely found in cervical adenocarcinomas regardless of the type of HPV infection. There was no correlation between HPV infection and clinical stage or pathologic type of tumor.

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인유두종 바이러스의 감염 또는 감염되지 않은 자궁 경부 이형성증에서 p53 및 Ki-67의 발현김태전, 이훈택, 최숙경, 홍승복대한임상검사과학회 · 대한임상검사과학회지2004 · 제36권 제2호자궁경부 종양에서 인유두종 바이러스 아형에 관한 연구김판영, 배동한, 서정호, 이동운, 정동준, 선우재근대한산부인과학회 · Obstetrics & Gynecology Science2003 · 제46권 제10호자궁경부상피의 암화과정에 있어서 Cytokeratins 및 Ki-67의 발현과 인유두종 바이러스 16, 18형의 감염고석봉, 설의석, 이태성, 한치동대한산부인과학회 · Obstetrics & Gynecology Science2003 · 제46권 제6호세포학적 진단에 따른 인유두종 바이러스 유전자형의 분석김진각, 박미숙, 박호현, 배난영, 오동순, 조현욱대한임상검사과학회 · 대한임상검사과학회지2015 · 제47권 제1호한국여성에서 자궁경부암의 고위험군 인유두종바이러스의 동정권혁찬, 박민혜, 윤효진, 이방현, 이병관, 이상희, 임정애대한산부인과학회 · Obstetrics & Gynecology Science2004 · 제47권 제12호자궁경부 상피내 종양에서 인체 유두종바이러스의 검출서기춘대한임상검사과학회 · 대한임상검사과학회지1998 · 제30권 제3호

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