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한국인 희소돌기아교세포종의 1p/19q 이형접합소실 검사에 적합한 현미부수체 표지자

Adequate Microsatellite Markers for 1p/19q Loss of Heterozygosity of Oligodendroglial Tumors in Korean Patients

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참고문헌

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초록

Abstract

Background : It is well known that oligodendrogliomas can be divided into two groups according to the 1p/19q or 1p loss of heterozygosity (LOH) status because oligodendrogliomas with the 1p/19q LOH or the 1p LOH have a better prognosis and chemosensitivity. In this study, we investigated the adequate microsatellite markers for 1p/19q LOH of oligodendroglial tumors in Korean patients. Methods : We performed PCR that was based on the LOH test with the 1p (D1S508, D1S199, D1S2734, D1S186 & D1S312) and 19q (D19S219, D19S112, D19S412 & D19S596) microsatellite markers; these were the markers that were recommended by other researchers. We performed this PCR on microdissected paraffin embedded tissue blocks of 67 tumors from 56 cases. Results : The PCR based LOH analysis revealed that 3 microsatellite markers (D1S508, D1S2734 & D1S186) of 1p and 2 markers (D19S219 & D19S412) of 19q had higher heterozygosity scores than other markers. In addition, chromosomal LOH status using these selective markers showed a statistically significant difference of prognosis for oligodendroglial tumors. Conclusions : We can suggest that the microsatellite markers with high heterozygosity scores (D1S508, D1S2734, D1S186, D19S219 and D19S412) would be adequate microsatellite markers for a PCR based LOH test of oligodendroglial tumors in Korean patients.

참고문헌 (30)

  1. "Pathology and genetics of tumour of thenervous system.", pp.55~70 (2000), IARC Press
  2. "Central Brain Tumor Registry of the United States" (1995)
  3. "Tumors of the central nervous systemin Korea:a multicenter study of 3221 cases", 56, pp.251~259 (2002)
  4. "Specific genetic predictorsof chemotherapeutic response and survival in patients with anaplasticoligodendrogliomas.", 90, pp.1473~1479 (1998)
  5. "Alterations of chromosome arms 1pand 19q as predictors of survival in oligodendrogliomas,astrocytomas,and mixed oligoastrocytomas.", 18, pp.636~645 (2000)
  6. "Allelic loss of chromosome 1p andradiotherapy plus chemotherapy in patients with oligodendrogliomas.", 48, pp.825~830 (2000)
  7. "Molecular subtypes of anaplasticoligodendroglioma:implications for patient management at diagnosis.", 7, pp.839~845 (2001)
  8. "Molecular heterogeneity of oligodendrogliomassuggests alternative pathways in tumor progression.", 57, pp.1278~1281 (2001)
  9. "Localization of common deletionregions on 1p and 19q in human gliomas and their association withhistological subtype.", 18, pp.4144~4152 (1999)
  10. "Molecular genetic aspectsof oligodendrogliomas including analysis by comparative genomichybridization.", 155, pp.375~386 (1999)
  11. "hRAD54 gene and 1p highresolutiondeletion-mapping analyses in oligodendrogliomas,", 116, pp.142~147 (2000)
  12. "Oligodendroglial neoplasms:current concepts,misconceptions,and folklore.", 8, pp.183~199 (2001)
  13. "Identification of two distinct deleted regions on the short armof chromosome 1 and rare mutation of the CDKN2C gene from 1p32in oligodendroglial tumors.", 58, pp.1041~1050 (1999)
  14. "Oligodendroglioma:toward moleculardefinitions in diagnostic neuro-oncology.", 62, pp.111~126 (2003)
  15. "Genetic signature ofoligoastrocytomas correlates with tumor location and denotes distinctmolecular subsets.", 161, pp.313~319 (2002)
  16. "Losses of chromosomal arms 1pand 19q in the diagnosis of oligodendroglioma.", 14, pp.842~53 (2001)
  17. "Semiautomated assessmentof loss of heterozygosity and replication error in tumors.", 56, pp.3331~3337 (1996)
  18. "Loss of heterozygosity studiesrevisited:prior quantification of the amplifiable DNA content ofarchival samples improves efficiency and reliability.", 4, pp.150~158 (2002)
  19. "A classification of tumors of the glioma groupon a histogenetic basis with a correlation study of prognosis" (1926), Lippincott
  20. "Improvingdiagnostic accuracy and interobserver concordance in the classificationand grading of primary gliomas.", 79, pp.1381~1393 (1997)
  21. "Glioma classification:a molecularreappraisal.", 159, pp.779~786 (2001)
  22. "Distinction in gene expressionprofiles of oligodendrogliomas with and without allelic loss of 1p", 21, pp.3961~3968 (2002)
  23. "Oligodendroglioma:pathologyand molecular biology.", 58, pp.111~117 (2002)
  24. "Expression of cyclin A and topoisomerase II ofoligodendrogliomas is correlated with tumour grade,MIB-1 labellingindex and survival.", 42, pp.395~402 (2003)
  25. "Immunohistochemical markersfor prognosis of oligodendroglial neoplasms.", 58, pp.237~253 (2002)
  26. "Oligodendroglioma:CD44 as a possible prognostic opportunity.", 22, pp.169~175 (2003)
  27. "Impact of chromosome 1p status in response of oligodendrogliomato temozolomide:preliminary results.", 61, pp.267~273 (2003)
  28. "Moleculardiagnosis of oligodendroglioma in paraffin sections.", 83, pp.419~428 (2003)
  29. "Correlation between genetic alteration and long-termclinical outcome of patients with oligodendroglial tumors,with identificationof a consistent region of deletion on chromosome arm 1p.", 97, pp.2254~2261 (2003)
  30. "Survival rates and prognostic factorsin patients with intracranial oligodendroglioma:A retrospective multivariateanalysis.", 26, pp.109~112 (1997)

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