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논문KCI 등재

변성올리고핵산염으로 감작된 중합효소연쇄반응과 게놈비교보합법으로 연구한 뇌실막세포종의 유전체불균형

Genomic Imbalances in Ependymoma by Degenerate Oligonucleotide Primed PCR-Comparative Genomic Hybridization

김민경|박선화|김한성|김기진|박성혜|서연림
대한병리학회|2004.06|Journal of Pathology and Translational Medicine|제38권 제3호|pp. 133-137

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참고문헌

주제분류병리학

초록

Abstract

Background : The most consistent chromosomal abnormality in ependymomas, is loss of 22q (17-75%) and gain of 1q (0-50%). However, significance of this abnormality is uncertain. Methods : Genomic imbalances in 27 Korean ependymomas, including 21 low grade ependymomas, 4 anaplastic and 2 myxopapillary ependymomas, were analyzed by degenerate oligonucleotide primed-PCR-comparative genomic hybridization. Results : Common gains were found in 17 (63%), 20q (59%), 9q34 (41%), 15q24-qter (33%), 11q13 (30%), 12q23 (26%), 7q23-qter (26%), 16q23-qter (30%), 19 (26%), and 1q32-qter (22%). DNA amplification was identified in 12 tumors (44%). Chromosomal loss was a less common occurrence in our study, but was found in 13q (26%), 6q (19%), and 3 (11%). Conclusion : The recurrent gains or losses of the chromosomal regions which were identified in this study provide candidate regions that may be involved in the development and progression of ependymomas.

참고문헌 (31)

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