본문 바로가기
KERD
논문KCI 등재

유방조직에서 티로신 활성효소 수용체인 EphA2, c-met 및 c-erbB-2의 발현

The Expressions of Tyrosine Kinase Receptors, EphA2, c-met and c-erbB-2 in the Human Breast

조성진|박혜림|신형식|조현득|염범우|민수기|박영의
대한병리학회|2005.02|Journal of Pathology and Translational Medicine|제39권 제1호|pp. 15-22

1

조회

0

다운로드

0

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : Tyrosine kinase receptor (TKR) is an important protein for normal-development, growth and tumorigenesis in human tissues. The purpose of this study was to evaluate the effect of TKR in the progression of breast cancer. Methods : The expressions of EphA2, c-met and c-erbB-2 were examined, by using immunohistochemical methods and RT-PCR, in samples of breast tissue that included 111 samples of normal epithelium, 34 samples of ductal carcinoma in situ (DCIS), and 109 samples of invasive ductal carcinomas (IDC). The results were compared with the prognostic parameters of breast cancer including the tumor grade, growth pattern, lymph node metastasis and the expressions of ER, PR, p53 and Ki-67. Results : The protein expressions of the three TKRs were higher in DCIS and IDC than in normal epithelium. The protein expression of EphA2 was correlated with a tumor grade, a labeling index of Ki-67, and the protein expression of c-met. Overexpression of c-erbB-2 was correlated with lymph node metastasis. The mRNA levels of the three TKRs were correlated with each other in normal tissue and IDC. The level of c-met mRNA was higher in the low grade tumors. Conclusions : The three TKRs may play roles in the tumorigenesis of human breast cancer. The overexpressions of EphA2 and c-erbB-2 may be a poor prognostic parameter in breast cancers.

참고문헌 (30)

  1. "The cell^A molecular approach^2nd ed.", pp.523~570 (2000), Sunderland,MA: Sinauer
  2. "Differentialregulation of EphA2 in normal and malignant cells.", 162, pp.1037~1042 (2003)
  3. "Eph receptors and ephrins:Effectors of morphogenesis.", 126, pp.2033~2044 (1999)
  4. "Pathological prognostic factors in breast cancer The value of histological grades in breast cancer experiencefrom a large study with long-term follow-up", pp.403~10
  5. "Human dendritic cells express neuronal Eph receptor tyrosinekinases:role of EphA2 in regulating adhesion to fibronectin.", 102, pp.4431~4440 (2003)
  6. "Expression of the c-Met protooncogeneand its possible involvement in liver invasion in adult Tcellleukemia.", 9, pp.181~187 (2003)
  7. "Regulation of multipletumor microenvironment markers by overexpression of singleor paired combinations of erbB receptors.", 63, pp.3764~3774 (2003)
  8. "EphA2overexpression causes tumorigenesis of mammary epithelial cells.", 61, pp.2301~2306 (2001)
  9. "Growth factors in breast cancer.", 16, pp.559~589 (1995)
  10. "The VAB-1 Ephreceptor tyrosine kinase functions in neural and epithelial morphogenesisin C.elegans.", 92, pp.633~43 (1998)
  11. "Diverse roles for the Eph family ofreceptor tyrosine kinases in carcinogenesis.", 59, pp.58~67 (2002)
  12. "Expression of two novel eph-related receptor protein tyrosinekinases in mammary gland development and carcinogenesis", 9, pp.1461~7 (1994)
  13. "Unified nomenclature for Ephfamily receptors and their ligands,the ephrins.", 90, pp.403~404 (1997)
  14. "c-Cbl dependent EphA2protein degradation is induced by ligand binding.", 1, pp.79~87 (2002)
  15. "Met receptor tyrosinekinase:enhanced signaling through adapter proteins.", 19, pp.5582~5589 (2000)
  16. "Met,metastasis,motility and more.", 4, pp.915~925 (2003)
  17. "Coexpression ofhepatocyte growth factor and receptor(Met)in human breast carcinoma.", 148, pp.225~232 (1996)
  18. "c-met tyrosinekinase receptor expression is associated with abnormal betacateninexpression and favourable prognostic factors in invasivebreast carcinoma,", 36, pp.313~325 (2000)
  19. "Hepatocyte growth factor", scatterfactor-Met signaling in tumorigenicity and invasion, pp.1996, 74[DOI]
  20. "Immunoreactive hepatocytegrowth factor is a strong and independent predictor of recurrenceand survival in human breast cancer", 54, pp.1630~3 (1994)
  21. "Differential expression of NDF", neuregulin receptors ErbB-3 andErbB-4 and involvement in inhibition of neuronal differentiation., 1997, pp.15, 2803~2815
  22. "EGF-related peptidesand their receptors in mammary gland development.", 2, pp.109~117 (1997)
  23. "Heregulininduces in vivo proliferation and differentiation of mammary epitheliuminto secretory lobuloalveoli.", 7, pp.1031~1038 (1996)
  24. "Epidermal growthfactor receptor-immunohistochemical detection and clinical significancefor treatment of primary breast cancer.", 17, pp.2799~2802 (1997)
  25. "NDF", heregulin induces persistence of terminalend buds and adenocarcinomas in the mammary glands of transgenicmice., 1996, pp.12, 1781~1788
  26. "Overexpression of the humanEGF receptor confers an EGF-dependent transformed phenotype toNIH 3T3 cells", 51, pp.1063~70 (1987)
  27. "EGFR and cancer prognosis", 37(4), pp.~15 (2001)
  28. "Transformation mediatedby the human HER-2 gene independent of epidermal growthfactor receptor", 7, pp.1859~66 (1992)
  29. "Cellular responses to ErbB-2 overexpression in human mammaryluminal epithelial cells:comparison of mRNA and protein expression.", 90, pp.173~181 (2004)
  30. "DMBT1 expression isdown-regulated in breast cancer.", 4 (2004)

관련 논문AI추천

유방조직의 c-kit와 COX-2의 발현과 의의고숙경, 김은경, 이원미, 주종은대한병리학회 · Journal of Pathology and Translational Medicine2008 · 제42권 제3호유방암의 조직학적 악성도에 따른 에스트로겐 수용체(ER)와 프로게스테론 수용체(PR), 그리고 C-erbB-2 종양단백질 발현과의 상관관계김태전, 한경희대한임상검사과학회 · 대한임상검사과학회지2004 · 제36권 제2호유방암종에서 Vascular Endothelial Growth Factor-C 발현강명재, 문우성, 양선호, 이동근, 장규윤, 정명자대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제6호유방암종에서 MMp-2, MTI-MMP, TIMP-2 mRNA의 발현김동원, 이동화, 진소영대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제6호간세포암종에서 편평세포 성장인자와 c-ErbB-2의 발현 부재문우성, 박민영, 박호성, 손현진대한병리학회 · Journal of Pathology and Translational Medicine2004 · 제38권 제4호유방암의 악성도에 따른 스테로이드호르몬 수용체와 종양단백질의 발현과의 상관성김태전, 문희주, 배형준, 백운철대한임상검사과학회 · 대한임상검사과학회지2003 · 제35권 제1호

이 간행물의 다른 논문 (10건)

PTEN and p53 Mutations in Endometrial Carcinomas최재성, 노흥태, 이혜경, 이윤이, 나선영, 서광선pp. 1-8Microsatellite Instability and Mismatch Repair Protein (hMLH1, hMSH2) Expression in Intrahepatic Cholangiocarcinoma김우호, 강윤경pp. 9-14한국인 희소돌기아교세포종의 1p/19q 이형접합소실 검사에 적합한 현미부수체 표지자김호근, 김태승, 김세훈pp. 23-33자궁내 발달지연과 정상 말기임신 태반에서의 Telomerase 활성도와 MIB-1 및 Fas, Fas Ligand 발현차이에 관한 연구홍성란, 양문호, 전이경pp. 34-40유방암종에서 p130Cas 및 FHIT의 발현과 예후인자와의 상관성 연구강석진, 최현주, 유진영, 정지한, 강창석pp. 41-47
원문 보기