Metastatic Tumors to the Breast from Extramammary Malignancies
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Background : Metastases to the breast from extramammary malignancies are very rare. We describe here the clinicopathologic features of the metastatic breast tumors that were identified in Korean patients at a single institute. Methods : We analyzed the clinicopathologic data of the patients who were diagnosed between January 1989 and April 2009 at Asan Medical Center. Results : Only 31 (0.21%) patients with metastases to the breast from extramammary malignancies were diagnosed over a 20-year period, and 29 of them had available data. The mean time to the diagnosis of metastasis after the diagnosis of the primary malignancy was 21 months (range, 0 to 102 months). The most common primary site was the stomach, followed by the uterus and lung. The most common histologic type was adenocarcinoma. A common clinical presentation was a unilateral palpable mass. Most metastatic tumors had morphological features that were similar to those of their respective primary tumors. However, in situ carcinoma, microcalcification and desmoplastic reactions were rarely observed. Conclusions : Metastatic breast lesions from extramammary sites are extremely rare, and the stomach, uterus and lung could be considered as the common primary sites in Korean patients. The clinical history and comparing the morphology of the primary tumor with the morphology of the metastatic tumor are important for achieving the proper diagnosis.
Abstract
Background : Metastases to the breast from extramammary malignancies are very rare. We describe here the clinicopathologic features of the metastatic breast tumors that were identified in Korean patients at a single institute. Methods : We analyzed the clinicopathologic data of the patients who were diagnosed between January 1989 and April 2009 at Asan Medical Center. Results : Only 31 (0.21%) patients with metastases to the breast from extramammary malignancies were diagnosed over a 20-year period, and 29 of them had available data. The mean time to the diagnosis of metastasis after the diagnosis of the primary malignancy was 21 months (range, 0 to 102 months). The most common primary site was the stomach, followed by the uterus and lung. The most common histologic type was adenocarcinoma. A common clinical presentation was a unilateral palpable mass. Most metastatic tumors had morphological features that were similar to those of their respective primary tumors. However, in situ carcinoma, microcalcification and desmoplastic reactions were rarely observed. Conclusions : Metastatic breast lesions from extramammary sites are extremely rare, and the stomach, uterus and lung could be considered as the common primary sites in Korean patients. The clinical history and comparing the morphology of the primary tumor with the morphology of the metastatic tumor are important for achieving the proper diagnosis.
참고문헌 (18)
- Jemal A, "Cancer statistics,2008", CA Cancer J Clin, 58, pp.71~96 (2008)
- [URL]
- Gupta D, "Metastases to breast simulating ductal carcinoma in situ:report of two cases and review of the literature", Ann Diagn Pathol, 5, pp.15~20 (2001)
- Williams SA, "Metastases to the breast from nonbreast solid neoplasms:presentation and determinants of survival", Cancer, 110, pp.731~737 (2007)
- Georgiannos SN, "Secondary neoplasms of the breast:a survey of the 20th Century", Cancer, 92, pp.2259~2266 (2001)
- Alva S, "An update of tumor metastasis to the breast data", Arch Surg, 134, pp.450~ (1999)
- Schnitt SJ, "Biopsy interpretation of the breast" (2008), Lippincott Williams & Wilkins
- Lee AH, "The histological diagnosis of metastases to the breast from extramammary malignancies", J Clin Pathol, 60, pp.1333~1341 (2007)
- Kim SH, "Radiologic findings of metastatic tumors to the breast", J Korean Radiol Soc, 41, pp.601~606 (1999)
- Chung SY, "Imaging findings of metastatic disease to the breast", Yonsei Med J, 42, pp.497~502 (2001)
- Park JM, "Metastatic breast carcinoma from gastric cancer:a case report", J Korean Radiol Soc, 38, pp.1139~1141 (1998)
- Yan Z, "Prostatic adenocarcinoma metastatic to the breasts:report of a case with diagnosis by fine needle aspiration biopsy", Urology, 55, pp.590~ (2000)
- 조수연, "양쪽 유방에 전이한 꽈리연부육종 - 1예 보고 -", The Korean Journal of Pathology, 37(5), pp.365~368 (2003), 대한병리학회
- Kim TY, "A case of malignant melanoma presenting as a breast mass", J Korean Breast Cancer Soc, 6, pp.35~38 (2003)
- Kim JM, "Breast metastases from malignant melanoma", J Korean Breast Cancer Soc, 7, pp.205~208 (2004)
- Park YH, "A case of metastatic thyroid-papillary carcinoma to the breast", J Korean Breast Cancer Soc, 7, pp.55~58 (2004)
- 이영석, "원발성 침윤성 소엽암종으로 오진한 유방으로 전이된 갑상샘 수질암종 - 1예 보고 -", The Korean Journal of Pathology, 41(6), pp.412~415 (2007), 대한병리학회
- 우순주, "유방으로 전이된 간세포암 1예", 대한내과학회지, 72(3), pp.306~310 (2007), 대한내과학회