Distribution of Dendritic Cells and Regulatory T-Cells in Cutaneous Lymphomas
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background : Dendritic cells (DCs) play an important role in immune reactions. This study was designed to identify the distribution patterns of DCs and regulatory T-cells (Tregs) in cutaneous lymphomas. Methods : Immunohistochemistry was used to determine langerin expression on Langerhans cells, CD11b on inflammatory DCs, CD209 and CD11c on dermal DCs, CD303 on plasmacytic DCs, and Foxp3 on Tregs in 81 cases of cutaneous lymphomas. Results : Various DCs and Tregs were identified in most cutaneous lymphomas. Plasmacytic DCs, inflammatory DCs and Tregs were identified mainly in tumor areas, whereas dermal DCs were distributed both in the tumor and stromal areas. Among DCs, dermal DCs were most prominently identified in the cutaneous lymphomas not only in the tumor area but also in the stroma. The intense stromal infiltration of dermal DCs was consistent finding in T-cell lymphomas. Diffuse large B-cell lymphoma (DLBCL), not otherwise specified also showed intense stromal infiltration of dermal DCs, but stromal infiltration in DLBCL, leg type was relatively scant. Conclusions : The results suggest that all types of DCs and Tregs are involved in cutaneous lymphoma tumor immunity. Among them dermal DCs may play a dominant role.
Abstract
Background : Dendritic cells (DCs) play an important role in immune reactions. This study was designed to identify the distribution patterns of DCs and regulatory T-cells (Tregs) in cutaneous lymphomas. Methods : Immunohistochemistry was used to determine langerin expression on Langerhans cells, CD11b on inflammatory DCs, CD209 and CD11c on dermal DCs, CD303 on plasmacytic DCs, and Foxp3 on Tregs in 81 cases of cutaneous lymphomas. Results : Various DCs and Tregs were identified in most cutaneous lymphomas. Plasmacytic DCs, inflammatory DCs and Tregs were identified mainly in tumor areas, whereas dermal DCs were distributed both in the tumor and stromal areas. Among DCs, dermal DCs were most prominently identified in the cutaneous lymphomas not only in the tumor area but also in the stroma. The intense stromal infiltration of dermal DCs was consistent finding in T-cell lymphomas. Diffuse large B-cell lymphoma (DLBCL), not otherwise specified also showed intense stromal infiltration of dermal DCs, but stromal infiltration in DLBCL, leg type was relatively scant. Conclusions : The results suggest that all types of DCs and Tregs are involved in cutaneous lymphoma tumor immunity. Among them dermal DCs may play a dominant role.
참고문헌 (29)
- Lopez-Bravo M, "In vivo induction of immune responses to pathogens by conventional dendritic cells", Immunity, 29, pp.343~351 (2008)
- Shortman K, "Steady-state and inflammatory dendriticcell development", Nat Rev Immunol, 7, pp.19~30 (2007)
- Cirone M, "Suppression of dendritic cell differentiation through cytokines released by primary effusion lymphoma cells", Immunol Lett, 120, pp.37~41 (2008)
- Berger CL, "Langerhans cells:mediators of immunity and tolerance", Int J Biochem Cell Biol, 38, pp.1632~1636 (2006)
- Valladeau J, "Cutaneous dendritic cells", Semin Immunol, 17, pp.273~283 (2005)
- Perez L, "Comparative analysis of CD1a,S-100,CD83,and CD11c human dendritic cells in normal,premalignant,and malignant tissues", Histol Histopathol, 20, pp.1165~1172 (2005)
- Zaba LC, "Resident and"inflammatory"dendritic cells in human skin", J Invest Dermatol, 129, pp.302~308 (2009)
- Mutyambizi K, "The balance between immunityand tolerance:the role of Langerhans cells", Cell Mol Life Sci, 66, pp.831~840 (2009)
- Kaplan DH, "Insights into Langerhans cell function from Langerhans cell ablation models", Eur J Immunol, 38, pp.2369~2376 (2008)
- Ni X, "Induction of T-cell responses against cutaneous T-cell lymphomas ex vivo by autologous dendritic cells transfected with amplified tumor mRNA", J Invest Dermatol, 128, pp.2631~2639 (2008)
- Urosevic M, "Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatment", J Natl Cancer Inst, 97, pp.1143~1153 (2005)
- LeBoit PE, "World Health Organization classification of tumours: pathology and genetics of skin tumors", pp.166~228 (2006), IARC press
- Kimura A, "IL-6:regulator of Treg", Th17 balance, 2010, pp.40, 1830~1835
- Marin ND, "Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosis", Tuberculosis(Edinb), 90, pp.252~261 (2010)
- Chang KC, "Distribution patterns of dendritic cells and T cells in diffuse large B-cell lymphomas correlate with prognoses", Clin Cancer Res, 13(22 Pt 1), pp.6666~6672 (2007)
- Carbonnelle A, "Study of the reactive dendritic cells in small B-cell lymphoproliferations of the ski", Virchows Arch, 450, pp.441~447 (2007)
- Yamamoto M, "Enhancement of antitumor immunity by high levels of Th1 and Th17 with a combination of dendritic cell fusion hybrids and regulatory T cell depletion in pancreatic cancer", Oncol Rep, 22, pp.337~343 (2009)
- Horkheimer I, "Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation", Blood, 113, pp.5330~5339 (2009)
- Yamazaki S, "Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity", Immunol Rev, 212, pp.314~329 (2006)
- Stroopinsky D, "Allogeneic in-duced human FOXP3(+)IFN-gamma(+)T cells exhibit selective suppressive capacity", Eur J Immunol, 39, pp.2703~2715 (2009)
- Ju_rgens B, "Interferongamma-triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells", Blood, 114, pp.3235~3243 (2009)
- Eljaafari A, "IFN-gamma,as secreted during an alloresponse,induces differentiation of monocytes into tolerogenic dendritic cells,resulting in FoxP3+ regulatory T cell promotion", J Immunol, 183, pp.2932~2945 (2009)
- Darrasse-Je ze G, "Feedback control of regulatory T cell homeostasis by dendritic cells in vivo", J Exp Med, 206, pp.1853~1862 (2009)
- Daudt L, "Interleukin-15 favors the expansion of central memory CD8+ T cells in ex vivo generated,antileukemia human cytotoxic T lymphocyte lines", J Immunother, 31, pp.385~393 (2008)
- Giermasz AS, "Type-1 polarized dendritic cells primed for high IL-12 production show enhanced activity as cancer vaccines", Cancer Immunol Immunother, 58, pp.1329~1336 (2009)
- Wilcox RA, "Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells", Blood, 114, pp.2936~2944 (2009)
- Kutzner H, "CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma:diagnostic and pathogenetic implications", Am J Surg Pathol, 33, pp.1307~1313 (2009)
- Nunez R, "Functional and structural characterization of two populations of human monocyte-derived dendritic cells", Exp Mol Pathol, 77, pp.104~115 (2004)
- Onodera M, "Factor XIIIa-positive dermal dendritic cells in keloids and hypertrophic and mature scars", Pathol Int, 57, pp.337~342 (2007)