Mammary-Type Myofibroblastoma: A Report of Two Cases
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Mammary-type myofibroblastoma (MFB) is a rare, benign spindle cell neoplasm occurring along the milkline, with extension from the mid-axilla to the medial groin. It is histologically and immunohistochemically identical to MFB of the breast and is part of a spectrum of lesions that includes spindle cell lipoma and cellular angiofibroma. Recently, we experienced two cases of mammarytype MFB involving male patients aged 30 and 58 years, respectively. The tumors were located in the right scrotal sac and in the right axilla. Wide excisions were performed. Microscopically, the masses were composed of haphazardly arranged, variably sized fascicles of bland spindle cells and were admixed with mature fat tissue. The spindle cells in both cases showed immunopositivity for desmin and CD34 and negativity for smooth muscle actin. Loss of retinoblastoma (RB)/13q14 loci is a characteristic genetic alteration of mammary-type MFB, and we identified loss of RB protein expression by immunohistochemical staining. We emphasize the importance of awareness of this rare neoplasm when a spindle cell neoplasm is accompanied by desmin immunopositivity. The second patient was alive without recurrence for 20 months, and the first patient had not been followed.
Abstract
Mammary-type myofibroblastoma (MFB) is a rare, benign spindle cell neoplasm occurring along the milkline, with extension from the mid-axilla to the medial groin. It is histologically and immunohistochemically identical to MFB of the breast and is part of a spectrum of lesions that includes spindle cell lipoma and cellular angiofibroma. Recently, we experienced two cases of mammarytype MFB involving male patients aged 30 and 58 years, respectively. The tumors were located in the right scrotal sac and in the right axilla. Wide excisions were performed. Microscopically, the masses were composed of haphazardly arranged, variably sized fascicles of bland spindle cells and were admixed with mature fat tissue. The spindle cells in both cases showed immunopositivity for desmin and CD34 and negativity for smooth muscle actin. Loss of retinoblastoma (RB)/13q14 loci is a characteristic genetic alteration of mammary-type MFB, and we identified loss of RB protein expression by immunohistochemical staining. We emphasize the importance of awareness of this rare neoplasm when a spindle cell neoplasm is accompanied by desmin immunopositivity. The second patient was alive without recurrence for 20 months, and the first patient had not been followed.
참고문헌 (15)
- Hameed M, "Cellular angiofibroma is genetically similar to spindle cell lipoma: a case report", Cancer Genet Cytogenet, 177, pp.131~134 (2007)
- McMenamin ME, "Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma", Am J Surg Pathol, 25, pp.1022~1029 (2001)
- Mukonoweshuro P, "Paratesticular mammary-type myofibroblastoma", Histopathology, 50, pp.396~397 (2007)
- Arsenovic N, "Mammary-type myofibroblastoma of soft tissue", Indian J Pathol Microbiol, 54, pp.391~393 (2011)
- Millo NZ, "Mammary-type myofibroblastoma of the liver: multi-modality imaging features with histopathologic correlation", Abdom Imaging, 39, pp.482~487 (2014)
- Howitt BE, "Mammary-type myofibroblastoma: clinicopathologic characterization in a series of 143 cases", Am J Surg Pathol, 40, pp.361~367 (2016)
- Fletcher CD, "WHO classification of tumours of soft tissue and bone", pp.61~62 (2013), IARC Press
- Hox V, "Extramammary myofibroblastoma in the head and neck region", Head Neck, 31(31), pp.1240~1244 (2009)
- Maggiani F, "Extramammary myofibroblastoma is genetically related to spindle cell lipoma", Virchows Arch, 449, pp.244~247 (2006)
- Flucke U, "Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma", Mod Pathol, 24, pp.82~89 (2011)
- Fritchie KJ, "Solitary fibrous tumor: is there a molecular relationship with cellular angiofibroma, spindle cell lipoma, and mammary-type myofibroblastoma?", Am J Clin Pathol, 137, pp.963~970 (2012)
- Magro G, "Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region", Hum Pathol, 43, pp.1887~1893 (2012)
- Magro G, "Chromosome 13q14 deletion in a mammary-type myofibroblastoma of the big toe: reply", Hum Pathol, 46, pp.344~345 (2015)
- Gengler C, "Solitary fibrous tumour and haemangiopericytoma: evolution of a concept", Histopathology, 48, pp.63~74 (2006)
- Meguerditchian AN, "Solitary fibrous tumor of the breast and mammary myofibroblastoma: the same lesion?", Breast J, 14, pp.287~292 (2008)