Superficial CD34-Positive Fibroblastic Tumor: Two Case Reports
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초록
Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described disease entity characterized by marked nuclear pleomorphism, low mitotic count, and diffuse CD34 posi- tivity. It is a rare, distinctive, low-grade fibroblastic neoplasm. To date, only 44 cases have been reported in the English-language literature. Herein, we report two cases of SCPFT in- volving a 48-year-old male and a 22-year-old male with superficial tumors on the right and left thighs, respectively. Excision was performed in both cases. Histologically, both tumors showed spindle-to-epithelioid cells arranged in fascicular or sheet-like patterns. Most cells displayed granular or eosinophilic glassy cytoplasm, marked nuclear pleomorphism, and a low mitotic rate. On immunohistochemical staining, tumor cells were diffusely positive for CD34 and negative for S100 protein, smooth muscle actin, and desmin. After wide exci- sion, neither patient experienced recurrence or metastasis after 16 months and 11 months of clinical follow-up, respectively. To the best of our knowledge, these are the first two cases of SCPFT reported in Korea. We believe these case reports would contribute to the clini- copathological understanding of SCPFT and assist clinicians in differentiating this tumor from other superficial soft tissue neoplasms.
Abstract
Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described disease entity characterized by marked nuclear pleomorphism, low mitotic count, and diffuse CD34 posi- tivity. It is a rare, distinctive, low-grade fibroblastic neoplasm. To date, only 44 cases have been reported in the English-language literature. Herein, we report two cases of SCPFT in- volving a 48-year-old male and a 22-year-old male with superficial tumors on the right and left thighs, respectively. Excision was performed in both cases. Histologically, both tumors showed spindle-to-epithelioid cells arranged in fascicular or sheet-like patterns. Most cells displayed granular or eosinophilic glassy cytoplasm, marked nuclear pleomorphism, and a low mitotic rate. On immunohistochemical staining, tumor cells were diffusely positive for CD34 and negative for S100 protein, smooth muscle actin, and desmin. After wide exci- sion, neither patient experienced recurrence or metastasis after 16 months and 11 months of clinical follow-up, respectively. To the best of our knowledge, these are the first two cases of SCPFT reported in Korea. We believe these case reports would contribute to the clini- copathological understanding of SCPFT and assist clinicians in differentiating this tumor from other superficial soft tissue neoplasms.
참고문헌 (20)
- Carter JM, "Superficial CD34-positive fibroblastic tumor : report of 18 cases of a distinctive low-grade mesenchymal neoplasm of intermediate(borderline)malignancy", Mod Pathol, 27, pp.294~302 (2014)
- Batur S, "Superficial CD34 positive fibroblastic tumor : report of three cases and review of the literature", Int J Dermatol, 58, pp.416~422 (2019)
- Donaldson MR, "Superficial CD34-positive fibroblastic tumor treated with Mohs micrographic surgery", Dermatol Surg, 43, pp.1489~1491 (2017)
- Florek AG, "Superficial CD34-positive fibroblastic tumor successfully treated with mohs micrographic surgery", Dermatol Surg, 44, pp.313~315 (2018)
- Hamada T, "Additional case of superficial CD34-positive fibroblastic tumor in a Japanese patient", J Dermatol, 46, pp.e134~e136 (2019)
- Hendry SA, "Superficial CD34-positive fibroblastic tumour : report of two new cases", Pathology, 47, pp.479~482 (2015)
- Lao IW, "Superficial CD34-positive fibroblastic tumour : a clinicopathological and immunohistochemical study of an additional series", Histopathology, 70, pp.394~401 (2017)
- Lin TL, "Superficial CD34-positive fibroblastic tumor : a case report and review of the literature", Am J Dermatopathol, 42, pp.68~71 (2020)
- Mao X, "Superficial CD34-positive fibroblastic tumor : report of two cases and review of literature", Int J Clin Exp Pathol, 13, pp.38~43 (2020)
- Rekhi B, "Superficial CD34-positive fibroblastic tumor in the forearm of a middle-aged patient : a newly described, rare soft-tissue tumor", Indian J Pathol Microbiol, 61, pp.421~424 (2018)
- Sood N, "Superficial CD34-positive fibroblastic tumor : a new entity; case report and review of literature", Indian J Pathol Microbiol, 60, pp.377~380 (2017)
- Wada N, "Superficial CD34-positive fibroblastic tumor : a new case from Japan", J Dermatol, 43, pp.934~936 (2016)
- Yamaga K, "Detailed analysis of a superficial CD34-positive fibroblastic tumor : a case report and review of the literature", Oncol Lett, 14, pp.3395~3400 (2017)
- Brenn T, "Pleomorphic dermal neoplasms : a review", Adv Anat Pathol, 21, pp.108~130 (2014)
- Soleymani T, "Atypical fibroxanthoma and pleomorphic dermal sarcoma : updates on classification and management", Dermatol Clin, 37, pp.253~259 (2019)
- Ieremia E, "Myxoinflammatory fibroblastic sarcoma : morphologic and genetic updates", Arch Pathol Lab Med, 138, pp.1406~1411 (2014)
- Laskin WB, "Myxoinflammatory fibroblastic sarcoma : a clinicopathologic analysis of 104 cases, with emphasis on predictors of outcome", Am J Surg Pathol, 38, pp.1~12 (2014)
- Llombart B, "Dermatofibrosarcoma protuberans : a clinicopathological, immunohistochemical, genetic(COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade(fibrosarcomatous)tumors", J Am Acad Dermatol, 65, pp.564~575 (2011)
- Mentzel T, "Myxofibrosarcoma. Clinicopathologic analysis of 75cases with emphasis on the low-grade variant", Am J Surg Pathol, 20, pp.391~405 (1996)
- Hasegawa T, "Expression of smooth muscle markers in so called malignant fibrous histiocytomas", J Clin Pathol, 56, pp.666~671 (2003)