Cyclosporin A에 의한 치은 증식증에서 FGF-5와 FGF-7의 발현 양상에 대한 연구
The expression of FGF-5 and FGF-7 in the cyclosporin a-induced gingival hyperplasia
0
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Cyclosporin A-induced gingival hyperplasia is frequently found in the patients who have been received an immunosuppressant for the organ transplantation. However, its exact mechanism is still unknown. The expression of FGF-5 and FGF-7 were studied in cyclosporine A-induced gingival hyperplasia (CGH) and inflammatory gingival hyperplasia (IGH). Immunohistochemistry and in situ hybridization were used for localization of protein and mRNA. The expression of FGF-5 and FGF-7 was different from CGH and IGH. FGF-5 and FGF-7 was strongly expressed in fibroblast in CGH (P<0.005 and P<0.05, respectively). FGF-5 mRNA was localized in the middle portion of connective tissue. FGF-7 mRNA was also identified in fibroblasts and mast cells. In conclusion, FGF-5 and FGF-7 were produced excessively by fibroblasts in CGH. Considering their known functions, their expression in CGH is important for production of collagen and proliferation of fibroblasts.
참고문헌 (15)
- "Cyclosporine A inhibits T-cell growth factor gene expres-sion at the level of mRNA transcription", 81, pp.5214~5218
- "The effects of cyclosporin A on the immune system", 3, pp.397~423 (1985)
- "Expression ofbFGF,KGF and FGF receptors on normal oral mucosa and SCC", 32b, pp.76~82 (1996)
- "Fas ligation induces apoptosis of CD40-activatedhuman B lymphocytes", 182, pp.1265~1273 (1995)
- "OPGL is a key regulator of osteoclastogenesis, lymphocyte devel-opment and lymph-node organogenesis", 397, pp.315~323 (1999)
- "Ultrastructural and histochemical features of the groundsubstance in cyclosporon A induced gingival hyperplasia", 67, pp.21~27 (1996)
- "FGF-5 stimulates expansion of connective tissue fibroblast andinhibits skeletal muscle development in the limb", 219, pp.368~380 (2000)
- "Large induction of keratinocyte growth factor expres-sion in the dermis during wound healing", 89, pp.6896~6900
- "Mast cell are not involved in the development of cyclosporin A-induced gingival hyperplasia:A study with mast cell-deficient mice", 71, pp.1117~1120 (1990)
- "Activation of fibroblast in collagen lattices by mast cellextract:a model of fibrosis", 30, pp.485~492 (2000)
- "Cytokines and Fas regulate apoptosis in murine renalinterstitial fibroblast", 8, pp.1845~1854 (1997)
- "Fas ligation induces apoptosis of CD40-activatedhuman B lymphocytes", 182, pp.1265~1273 (1995)
- "Heterogeneity of collagensynthesis in normal and systemic sclerosis skin fibroblasts.Increased proportion of high collagen-producing cells in systemicsclerosis fibroblasts", 39, pp.1338~1346 (1996)
- "Cyclosporine stimulates expression oftransforming growth factor-beta in renal cells.Possible mechanism ofcyclosporines proliferative effects", 60, pp.237~241 (1995)
- "Regulation of human gingival fibroblast growth and syntheticactivity by cyclosporin-A in vitro", 24, pp.314~321 (1989)