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논문KCI 등재

치아와 골형성에서의 Runx2와 Osterix의 기능

Function of Runx2 and osterix in osteogenesis and teeth

김정은
대한구강악안면외과학회 (Korean Association Of Oral And Maxillofacial Surgeons)|2007.08|대한구강악안면외과학회지 (Journal of the Korean Association of Oral and Maxillofacial Surgeons)|제33권 제4호|pp. 381-385

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참고문헌

주제분류치의학

초록

Abstract

Bone is a dynamic organ that bone remodeling occurs throughout life and involves the process in which the bone matrix is broken down through resorption by osteoclasts and then built back again through bone formation by osteoblasts. Usually these two processes balance each other and a stable level of bone mass is maintained. We here discuss transcription factors involved in regulating the osteoblast differentiation pathway. Runx2 is a transcription factor which is essential in skeletal development by regulating osteoblast differentiation and chondrocyte maturation. Its companion subunit, Cbfβis needed for an early step in osteoblast differentiation pathway. Whereas Osterix (Osx) is a new identified osteoblast-specific transcription factor which is required for the differentiation of preosteoblasts into more mature and functional osteoblasts. We also discuss other transcription factors, Msx1 and 2, Dlx5 and 6, Twist, and Sp3 that affect skeletal patterning and development. Understanding the characteristics of mice in which these transcription factors are inactivated should help define their role in bone physiology and pathology of bone defects.

참고문헌 (35)

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관련 논문AI추천

Expression pattern of Runx2 in murine tooth development김영진, 김태완, 김현정, 남순현, 류현모대한소아치과학회 · 대한소아치과학회지2004 · 제31권 제4호출생 후 골격 형성에서 골형성 전사인자 Osterix에 의한 관련 유전자 변화김정은, 백욱영대한골다공증학회 · OSTEOPOROSIS2011 · 제9권 제1호치아 기관배양시 골형성단백의 역할에 관한 연구정일혁, 정종훈, 정필훈대한구강악안면외과학회 · 대한구강악안면외과학회지2004 · 제30권 제5호Immunolocalization of Runx2 and Osterix in the Developing Periodontal Tissues of the Mouse김지연, 주성숙, Byung-In Kim, Je-Won Shin, Seung-Hoon Na대한구강생물학회 · International Journal of Oral Biology2011 · 제36권 제2호상아모세포 관련 유전자, OD314의 발현과 기능 연구김두현, 김흥중, 박주철, 손호현, 정문진대한치과보존학회 · Restorative Dentistry and Endodontics2004 · 제29권 제4호Interrelationship of Runx2 and estrogen pathway in skeletal tissues정재환, 최제용생화학분자생물학회 · BMB Reports2011 · 제44권 제10호

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