Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The purpose of this study is to report a rare case of mandibular adenocarcinoma that was diagnosed due to metastasis from the prostate. Numb chin syndrome (NCS), which was associated with this case, is also discussed. Computed tomography (CT) and an intraoral incisional biopsy of the left man-dibular area were performed. Urology consultation, hormone therapy, chemotherapy and follow-up radiographic images were administered. Histologi-cal examination of the incised specimen revealed moderately differentiated adenocarcinoma. The Gleason score was 8 (primary 4/secondary 4). Immu-nohistochemical features and radiographic results confirmed the diagnosis of metastasis from prostate adenocarcinoma, moderately differentiated. The patient’s prostate-specific antigen (PSA) level was very high. After hormone treatment, the patient’s PSA levels dropped gradually. Seventeen months later, in May 2015, the PSA level was elevated. The 18-month follow-up CT image indicated that the patient’s condition was aggravated. Docetaxel chemotherapy was started in June 2015 (18 months later), and the sixth cycle of the therapy is in progress. Oral metastases that originate from prostate adenocarcinoma are rare and can induce various periosteal reactions. Hormone therapy, chemotherapy and close follow-up could be additional, appro-priate treatment, and were applied in this case. Finally, NCS is a valuable indicator of metastatic disease in the mandible.
Abstract
The purpose of this study is to report a rare case of mandibular adenocarcinoma that was diagnosed due to metastasis from the prostate. Numb chin syndrome (NCS), which was associated with this case, is also discussed. Computed tomography (CT) and an intraoral incisional biopsy of the left man-dibular area were performed. Urology consultation, hormone therapy, chemotherapy and follow-up radiographic images were administered. Histologi-cal examination of the incised specimen revealed moderately differentiated adenocarcinoma. The Gleason score was 8 (primary 4/secondary 4). Immu-nohistochemical features and radiographic results confirmed the diagnosis of metastasis from prostate adenocarcinoma, moderately differentiated. The patient’s prostate-specific antigen (PSA) level was very high. After hormone treatment, the patient’s PSA levels dropped gradually. Seventeen months later, in May 2015, the PSA level was elevated. The 18-month follow-up CT image indicated that the patient’s condition was aggravated. Docetaxel chemotherapy was started in June 2015 (18 months later), and the sixth cycle of the therapy is in progress. Oral metastases that originate from prostate adenocarcinoma are rare and can induce various periosteal reactions. Hormone therapy, chemotherapy and close follow-up could be additional, appro-priate treatment, and were applied in this case. Finally, NCS is a valuable indicator of metastatic disease in the mandible.
참고문헌 (13)
- Shen ML, "Metastatic tumors to the oral and maxillofacial region: a retrospective study of 19 cases in West China and review of the Chinese and English literature", J Oral Maxillofac Surg, 67, pp.718~737 (2009)
- Hirshberg A, "Metastatic tumours to the oral cavity: pathogenesis and analysis of 673cases", Oral Oncol, 44, pp.743~752 (2008)
- Aksoy S, "Metastasis of prostate carcinoma in the mandible manifesting as numb chin syndrome", World J Surg Oncol, 12, pp.401~ (2014)
- Daley T, "Metastases to the mouth and jaws: a contemporary Canadian experience", J Can Dent Assoc, 77, pp.b67~ (2011)
- Menezes JD, "Mandibular metastasis of adenocarcinoma from prostate cancer: case report according to epidemiology and current therapeutical trends of the advanced prostate cancer", J Appl Oral Sci, 21, pp.490~495 (2013)
- Saijo H, "Metastasis of prostate cancer to the mandibular condyle", Asian J Oral Maxillofac Surg, 20, pp.86~88 (2008)
- Tchan MC, "Metastatic prostate cancer mimicking primary osteosarcoma of the jaw: an infrequent clinical case", South Med J, 101, pp.657~659 (2008)
- Soares EC, "Metastatic prostate adenocarcinoma associated with numb chin syndrome", J Craniofac Surg, 22, pp.2366~2368 (2011)
- Zaheer F, "Unusual presentation of 'numb chin syndrome' as the manifestation of metastatic adenocarcinoma of the lung", Int J Surg Case Rep, 4, pp.1097~1099 (2013)
- Narendra H, "Numb chin syndrome as a manifestation of metastatic squamous cell carcinoma of esophagus", J Cancer Res Ther, 5, pp.49~51 (2009)
- Evans RW, "Numb chin syndrome", Headache, 48, pp.1520~1524 (2008)
- Wenaden AE, "Imaging of periosteal reactions associated with focal lesions of bone", Clin Radiol, 60, pp.439~456 (2005)
- Reyes Court D, "Prostatic adenocarcinoma with mandibular metastatic lesion: case report", Med Oral Patol Oral Cir Bucal, 12, pp.E424~427 (2007)