Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects
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Objectives: Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the SOST gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects.Materials and Methods: In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic peri-odontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test.Results: Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (P<0.005). Conclusion: Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.
Abstract
Objectives: Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the SOST gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects.Materials and Methods: In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic peri-odontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test.Results: Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (P<0.005). Conclusion: Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.
참고문헌 (18)
- Kornman KS, "The host response to the microbial challenge in periodontitis: assembling the players", Periodontol 2000, 14, pp.33~53 (1997)
- Bascones-Martínez A, "Host defence mechanisms against bacterial aggression in periodontal disease: basic mechanisms", Med Oral Patol Oral Cir Bucal, 14, pp.e680~e685 (2009)
- Kumar PS, "New bacterial species associated with chronic periodontitis", J Dent Res, 82, pp.338~344 (2003)
- Buduneli N, "Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis", J Clin Periodontol, 38(Suppl 11), pp.85~105 (2011)
- Champagne CM, "Potential for gingival crevice fluid measures as predictors of risk for periodontal diseases", Periodontol 2000, 31, pp.167~180 (2003)
- Robling AG, "Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost", sclerostin, 2008, pp.283, 5866~5875
- Winkler DG, "Osteocyte control of bone formation via sclerostin, a novel BMP antagonist", EMBO J, 22, pp.6267~6276 (2003)
- Silverman SL, "Sclerostin", J Osteoporos, 2010, pp.941419~ (2010)
- Poole KE, "Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation", FASEB J, 19, pp.1842~1844 (2005)
- Atkins GJ, "Sclerostin is a locally acting regulator of late-osteoblast", preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism, 2011, pp.26, 1425~1436
- Ren Y, "Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model", FASEB J, 29, pp.2702~2711 (2015)
- Balli U, "Gingival crevicular fluid levels of sclerostin, osteoprotegerin, and receptor activator of nuclear factor-κB ligand in periodontitis", J Periodontol, 86, pp.1396~1404 (2015)
- Li X, "Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength", J Bone Miner Res, 23, pp.860~869 (2008)
- Griffiths GS, "Formation, collection and significance of gingival crevice fluid", Periodontol 2000, 31, pp.32~42 (2003)
- Li X, "Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis", J Bone Miner Res, 24, pp.578~588 (2009)
- Ominsky MS, "Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength", J Bone Miner Res, 25, pp.948~959 (2010)
- Yang X, "Effect of sclerostin removal in vivo on experimental periodontitis in mice", J Oral Sci, 58, pp.271~276 (2016)
- Taut AD, "Sclerostin antibody stimulates bone regeneration after experimental periodontitis", J Bone Miner Res, 28, pp.2347~2356 (2013)