Effects of scaling and root planing with or without a local drug delivery system on the gingival crevicular fluid leptin level in chronic periodontitis patients: a clinico-biochemical study
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Purpose: The present split mouth study evaluates the effect of nonsurgical periodontaltreatment on the gingival crevicular fluid (GCF) leptin level in chronic periodontitis. Methods: Ninety sites from 30 nonobese chronic periodontitis patients were selected anddivided as follows: group I, 30 healthy sites receiving no treatment; group II, 30 periodontitissites receiving scaling and root planing (SRP); and group III, 30 periodontitis sites receivingSRP with tetracycline local drug delivery. At baseline, after GCF sampling and clinicalparameter recording, the assigned treatment was performed for the study groups. Duringrecall visits, GCF sampling followed by clinical parameter recording was done for groups IIand III. Results: Reductions in the probing depth and the clinical attachment level (CAL) werehighly significant at different time intervals (except between day 0 and 45) in both groupsII and III. Upon comparison, group III showed significant gain in CAL between day 0 and 15and between day 0 and 45. After treatment, the reduction in the GCF leptin level was moresignificant in group III than in group II at day 15 but re-elevated almost to the pretreatmentlevels at day 45. Conclusions: Nonsurgical periodontal therapies were not effective in maintaining stablereduction in the GCF leptin level during the study period.
Abstract
Purpose: The present split mouth study evaluates the effect of nonsurgical periodontaltreatment on the gingival crevicular fluid (GCF) leptin level in chronic periodontitis. Methods: Ninety sites from 30 nonobese chronic periodontitis patients were selected anddivided as follows: group I, 30 healthy sites receiving no treatment; group II, 30 periodontitissites receiving scaling and root planing (SRP); and group III, 30 periodontitis sites receivingSRP with tetracycline local drug delivery. At baseline, after GCF sampling and clinicalparameter recording, the assigned treatment was performed for the study groups. Duringrecall visits, GCF sampling followed by clinical parameter recording was done for groups IIand III. Results: Reductions in the probing depth and the clinical attachment level (CAL) werehighly significant at different time intervals (except between day 0 and 45) in both groupsII and III. Upon comparison, group III showed significant gain in CAL between day 0 and 15and between day 0 and 45. After treatment, the reduction in the GCF leptin level was moresignificant in group III than in group II at day 15 but re-elevated almost to the pretreatmentlevels at day 45. Conclusions: Nonsurgical periodontal therapies were not effective in maintaining stablereduction in the GCF leptin level during the study period.
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