Malignant Syndrome in Parkinson Disease Similar to Severe Infection
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A 70-year-old woman with Parkinson disease was admitted to the emergency department with altered consciousness, fever and convulsive movements without experiencing withdrawal from antiparkinsonian medication. Six hours after the emergency department visit, the patient had a hyperpyrexia (>40°C) and a systolic blood pressure of 40 mmHg. There was no evidence of bacterial infection based on extensive workups. The patient was discharged without aggravation of Parkinson disease symptoms after treatment that included administration of dantrolene sodium, enforcement of continuous renal replacement therapy and cooling blankets. Malignant syndrome should be suspected if high fever occurs in Parkinson disease patients without evidence of a definitive infection.
Abstract
A 70-year-old woman with Parkinson disease was admitted to the emergency department with altered consciousness, fever and convulsive movements without experiencing withdrawal from antiparkinsonian medication. Six hours after the emergency department visit, the patient had a hyperpyrexia (>40°C) and a systolic blood pressure of 40 mmHg. There was no evidence of bacterial infection based on extensive workups. The patient was discharged without aggravation of Parkinson disease symptoms after treatment that included administration of dantrolene sodium, enforcement of continuous renal replacement therapy and cooling blankets. Malignant syndrome should be suspected if high fever occurs in Parkinson disease patients without evidence of a definitive infection.
참고문헌 (9)
- Takubo H, "A collaborative study on the malignant syndrome in Parkinson disease and related disorders", Parkinsonism Relat Disord, 9(Suppl 1), pp.S31~S41 (2003)
- Levenson JL., "Neuroleptic malignant syndrome", Am J Psychiatry, 142, pp.1137~1145 (1985)
- Mizuno Y, "Malignant syndrome in Parkinson disease: concept and review of the literature", Parkinsonism Relat Disord, 9(Suppl 1), pp.S3~S9 (2003)
- Chandran CJ., "Malignant syndrome in Parkinson disease without dopaminergic drug withdrawal", Ann Indian Acad Neurol, 11, pp.248~250 (2008)
- Sechi G, "Acute hyponatremia and neuroleptic malignant syndrome in Parkinson disease", Prog Neuropsychopharmacol Biol Psychiatry, 20, pp.533~542 (1996)
- Cao L, "Acute hypernatremia and neuroleptic malignant syndrome in Parkinson disease", Am J Med Sci, 318, pp.67~68 (1999)
- Broman M, "Malignant hyperthermia, a Scandinavian update", Acta Anaesthesiol Scand, 59, pp.951~961 (2015)
- Becker KL, "Procalcitonin assay in systemic inflammation, infection, and sepsis:clinical utility and limitations", Crit Care Med, 36, pp.941~952 (2008)
- Lovas A, "Extreme procalcitonin elevation without proven bacterial infection related to amphetamine abuse", Case Rep Crit Care, 2014, pp.179313~ (2014)