Recent Updates of the Diagnosis and Prevention of Venous Thromboembolism in Patients with a Hip Fracture
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Venous thromboembolism (VTE) is a potentially fatal complication that is relatively common after hip surgery. Since patients with a hip fracture have a higher risk of preoperative VTE due to an inability to ambulate after injury and aggravation of underlying age-related conditions, it may be difficult to effectively prevent VTE using only conventional approaches. Very few studies have been published reporting on the prevalence and prevention of VTE in patients with a hip fracture compared to those with hip arthroplasty. For this reason, we aimed to share recent updates on the diagnosis and prevention of VTE in patients with a hip fracture. Preoperative screening tests to diagnose VTE need to be performed more actively following hip fracture and indirect multidetector computed tomography venography is considered the most effective test for this purpose. As the risk of VTE appears to increase with time following a hip fracture, preventive measures should be taken as soon as possible in patients with a hip fracture. A wide variety of mechanical and pharmacological options are available for prophylaxis. When considering patient compliance and preventive impact, intermittent pneumatic compression devices and foot pumps are recommended as mechanical modalities. Of the available preventive medications for patients with a hip fracture, low molecular weight heparin seems to be the most appropriate option because of its short half-life and fast onset of action. Surgery should be performed as soon as possible in patients with hip fractures, and we recommend mechanical and pharmacological methods as active interventions immediately after injury to prevent VTE.
Abstract
Venous thromboembolism (VTE) is a potentially fatal complication that is relatively common after hip surgery. Since patients with a hip fracture have a higher risk of preoperative VTE due to an inability to ambulate after injury and aggravation of underlying age-related conditions, it may be difficult to effectively prevent VTE using only conventional approaches. Very few studies have been published reporting on the prevalence and prevention of VTE in patients with a hip fracture compared to those with hip arthroplasty. For this reason, we aimed to share recent updates on the diagnosis and prevention of VTE in patients with a hip fracture. Preoperative screening tests to diagnose VTE need to be performed more actively following hip fracture and indirect multidetector computed tomography venography is considered the most effective test for this purpose. As the risk of VTE appears to increase with time following a hip fracture, preventive measures should be taken as soon as possible in patients with a hip fracture. A wide variety of mechanical and pharmacological options are available for prophylaxis. When considering patient compliance and preventive impact, intermittent pneumatic compression devices and foot pumps are recommended as mechanical modalities. Of the available preventive medications for patients with a hip fracture, low molecular weight heparin seems to be the most appropriate option because of its short half-life and fast onset of action. Surgery should be performed as soon as possible in patients with hip fractures, and we recommend mechanical and pharmacological methods as active interventions immediately after injury to prevent VTE.
참고문헌 (48)
- Kannus P, "Hip fractures in Finland between 1970 and 1997 and predictions for the future", Lancet, 353, pp.802~805 (1999)
- Roberts SE, "Time trends and demography of mortality after fractured neck of femur in an English population, 1968-98: database study", BMJ, 327, pp.771~775 (2003)
- McLaughlin MA, "Preoperative status and risk of complications in patients with hip fracture", J Gen Intern Med, 21, pp.219~225 (2006)
- Perez JV, "Death after proximal femoral fracture--an autopsy study", Injury, 26, pp.237~240 (1995)
- Powers PJ, "A randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of venous thromboembolism after surgery for fractured hip", Arch Intern Med, 149, pp.771~774 (1989)
- Agnelli G, "A randomised, double-blind, placebo-controlled trial of dermatan sulphate for prevention of deep vein thrombosis in hip fracture", Thromb Haemost, 67, pp.203~208 (1992)
- Hamilton HW, "Venous thrombosis in patients with fracture of the upper end of the femur. A phlebographic study of the effect of prophylactic anticoagulation", J Bone Joint Surg Br, 52, pp.268~289 (1970)
- Shin WC, "Preoperative prevalence of and risk factors for venous thromboembolism in patients with a hip fracture: An indirect multidetector CT venography study", J Bone Joint Surg Am, 98, pp.2089~2095 (2016)
- Kim YH, "Prophylaxis for deep vein thrombosis with aspirin or low molecular weight dextran in Korean patients undergoing total hip replacement. A randomized controlled trial", Int Orthop, 22, pp.6~10 (1998)
- Yoo MC, "A prospective randomized study on the use of nadroparin calcium in the prophylaxis of thromboembolism in Korean patients undergoing elective total hip replacement", Int Orthop, 21, pp.399~402 (1997)
- Falck-Ytter Y, "Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines", Chest, 141(2 Suppl), pp.e278Se325S~ (2012)
- "Venous thromboembolism: reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in patients admitted to hospital. Clinical Guideline 92" (2010)[URL]
- "Management of hip fracture in older people: a national clinical guideline" (2009)[URL]
- Park YS, "Guideline for the Prophylaxis of Venous Thromboembolism in hip surgery patients", J Korean Orthop Assoc, 46, pp.95~98 (2011)
- Geerts WH, "A prospective study of venous thromboembolism after major trauma", N Engl J Med, 331, pp.1601~1606 (1994)
- Girasole GJ, "Diagnosis of deep vein thrombosis in elderly hip-fracture patients by using the duplex scanning technique", Orthop Rev, 23, pp.411~416 (1994)
- Smith EB, "Delayed surgery for patients with femur and hip fractures-risk of deep venous thrombosis", J Trauma, 70, pp.E113~E116 (2011)
- Hefley FG Jr, "Effect of delayed admission to the hospital on the preoperative prevalence of deep-vein thrombosis associated with fractures about the hip", J Bone Joint Surg Am, 78, pp.581~583 (1996)
- Roberts TS, "The preoperative prevalence and postoperative incidence of thromboembolism in patients with hip fractures treated with dextran prophylaxis", Clin Orthop Relat Res, (255), pp.198~203 (1990)
- Zahn HR, "The preoperative prevalence of deep vein thrombosis in patients with femoral neck fractures and delayed operation", Injury, 30, pp.605~607 (1999)
- "Venous thromboembolic diseases: the management of venous thromboembolic diseases and the role of thrombophilia testing" (2012)[URL]
- Goodacre S, "Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis", BMC Med Imaging, 5, pp.6~ (2005)
- Lensing AW, "Lower extremity venography with iohexol:results and complications", Radiology, 177, pp.503~505 (1990)
- McLachlan MS, "Observer variation in the interpretation of lower limb venograms", AJR Am J Roentgenol, 132, pp.227~229 (1979)
- Watanabe H, "The incidence of venous thromboembolism before and after total knee arthroplasty using 16-row multidetector computed tomography", J Arthroplasty, 26, pp.1488~1493 (2011)
- Loud PA, "Combined CT venography and pulmonary angiography in suspected thromboembolic disease: diagnostic accuracy for deep venous evaluation", AJR Am J Roentgenol, 174, pp.61~65 (2000)
- Cham MD, "Deep venous thrombosis: detection by using indirect CT venography. The Pulmonary Angiography-Indirect CT Venography Cooperative Group", Radiology, 216, pp.744~751 (2000)
- Perrier A, "Multidetector-row computed tomography in suspected pulmonary embolism", N Engl J Med, 352, pp.1760~1768 (2005)
- Monreal M, "A prospective double-blind trial of a low molecular weight heparin once daily compared with conventional low-dose heparin three times daily to prevent pulmonary embolism and venous thrombosis in patients with hip fracture", J Trauma, 29, pp.873~875 (1989)
- Richman PB, "Contribution of indirect computed tomography venography to computed tomography angiography of the chest for the diagnosis of thromboembolic disease in two United States emergency departments", J Thromb Haemost, 1, pp.652~657 (2003)
- Lightfoot CB, "Survey of radiologists’ knowledge regarding the management of severe contrast materialinduced allergic reactions", Radiology, 251, pp.691~696 (2009)
- Andreucci M, "Side effects of radiographic contrast media: pathogenesis, risk factors, and prevention", Biomed Res Int, 2014, pp.741018~ (2014)
- Katz DS, "Combined CT venography and pulmonary angiography: a comprehensive review", Radiographics, 22, pp.S3~S19 (2002)
- Shiga T, "Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression", Can J Anaesth, 55, pp.146~154 (2008)
- Moran CG, "Early mortality after hip fracture: is delay before surgery important?", J Bone Joint Surg Am, 87, pp.483~489 (2005)
- Uzoigwe CE, "Early and ultra-early surgery in hip fracture patients improves survival", Injury, 44, pp.726~729 (2013)
- Association of Anaesthetists of Great Britain and Ireland, "Management of proximal femoral fractures 2011: Association of Anaesthetists of Great Britain and Ireland", Anaesthesia, 67, pp.85~98 (2012)
- British Orthopaedic Association, "The care of patients with fragility fracture", pp.32~34 (2007), British Orthopaedic Association
- Eriksson BI, "Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery", N Engl J Med, 345, pp.1298~1304 (2001)
- Decousus H, "A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. Prévention du Risque d’Embolie Pulmonaire par Interruption Cave Study Group", N Engl J Med, 338, pp.409~415 (1998)
- Rosencher N, "Venous thromboembolism and mortality after hip fracture surgery: the ESCORTE study", J Thromb Haemost, 3, pp.2006~2014 (2005)
- Lieberman JR, "Prevention of venous thromboembolic disease after total hip and knee arthroplasty", J Bone Joint Surg Am, 95, pp.1801~1811 (2013)
- Gent M, "Low-molecular-weight heparinoid orgaran is more effective than aspirin in the prevention of venous thromboembolism after surgery for hip fracture", Circulation, 93, pp.80~84 (1996)
- "Thromboprophylaxis: orthopedic surgery" (2016)[URL]
- Imanaka S, "Use of a temporary caval filter in a young man with pulmonary embolism to prevent migration of massive caval thrombus during an attempt of caval thrombolysis", J Atheroscler Thromb, 6, pp.18~21 (2000)
- Protack CD, "Long-term outcomes of catheter directed thrombolysis for lower extremity deep venous thrombosis without prophylactic inferior vena cava filter placement", J Vasc Surg, 45, pp.992~997 (2007)
- Wärntges S, "Progress in the management of acute pulmonary embolism", Curr Opin Pulm Med, 21, pp.417~424 (2015)
- Mismetti P, "Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial", JAMA, 313, pp.1627~1635 (2015)
