자발성 세균성 복막염을 일으킨 그람음성간균의 3세대 세팔로스포린 내성률 변화
Trend of Resistance to the Third Generation Cephalosporin of Gram Negative F30 Bacteria in Patients with Spontaneous Bacterial Peritonitis
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초록
최근 9년간 서울대병원에서 치료받은 SBP 환자의 복수에서 분리된 그람음성간균의 3세대 세팔로스포린 항생제에 대한 내성률은 10.5%였고, 내성률은 시간이 지남에 따라 감소하였다.
Abstract
The third generation cephalosporin is widely used in treatment of spontaneous bacterial peritonitis (SBP). Resistance to the third generation cephalosporin was associated with poor outcome in patients with SBP. Thus it is necessary to know the changes in resistance rate. We planned to investigate retrospectively on resistance rate of the third generation cephalosporin of gram negative bacteria isolated in patients with SBP, who visited Seoul National University Hospital between 1998 and 2006. The Clinical and Laboratory Standards Institute guidelines were applied for antibiotic susceptibility test. A total of 269 consecutive episodes of clinically and microbiologically proven SBP was identified during the study period and 209 cases were caused by gram negative organisms. Among 209 isolates, 22 (10.5%) showed resistance to the third generation cephalosporin. The prevalence of resistance was decreasing during the study period (P=0.014).
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