Meropenem 단독요법에 반응하지 않았으나, ceftazidime과 trimethoprim- sulfamethoxazole 병합투여로 치료한 Burkholderia 균 혈증 및 감염성 척추염 1례
A Case of Burkholderia cepacia Bacteremia and Infective Spondylitis, Treated with Ceftazidime and Trimethoprim-Sulfamethoxazole Combination Therapy, which did not Respond to Carbapenem Monotherapy
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Burkholderia cepacia is an aerobic gram-negative rod that causes healthcareassociated infections through contaminated disinfectants, fluids, and medical equipment. This bacterium shows resistance to various antibiotics. For this reason, available therapeutic antimicrobial agents are limited, and the optimal antimicrobial therapeutic regimen was still not well- determined in the case of infective spondylitis. We experienced a case of B. cepacia bacteremia with infective spondylitis and paraspinal abscesses which did not respond to carbapenem monotherapy, but was did respond to ceftazidime and sulfamethoxzaole/trimethoprim combination therapy.
Abstract
Burkholderia cepacia is an aerobic gram-negative rod that causes healthcareassociated infections through contaminated disinfectants, fluids, and medical equipment. This bacterium shows resistance to various antibiotics. For this reason, available therapeutic antimicrobial agents are limited, and the optimal antimicrobial therapeutic regimen was still not well- determined in the case of infective spondylitis. We experienced a case of B. cepacia bacteremia with infective spondylitis and paraspinal abscesses which did not respond to carbapenem monotherapy, but was did respond to ceftazidime and sulfamethoxzaole/trimethoprim combination therapy.
참고문헌 (19)
- Mohr CD, "Cellular aspects of Burkholderia cepacia infection", Microbes Infect, 3, pp.425~435 (2001)
- Speert DP, "Advances in Burkholderia cepacia complex", Paediatr Respir Rev, 3, pp.230~235 (2002)
- Marioni G, "Cervical necrotizing fasciitis: a novel clinical presentation of Burkholderia cepacia infection", J Infect, 53, pp.e219~e222 (2006)
- Held MR, "Life-threatening sepsis caused by Burkholderia cepacia from contaminated intravenous flush solutions prepared by a compounding pharmacy in another state", Pediatrics, 118, pp.e212~e215 (2006)
- 양병혁, "Pyogenic Spondylitis in a Healthy Adult Caused by Burkholderia cepacia", Infection and Chemotherapy, 40(4), pp.233~236 (2008), 대한감염학회
- Smith MA, "Cervical osteomyelitis caused by Pseudomonas cepacia in an intravenous-drug abuser", J Clin Microbiol, 21, pp.445~446 (1985)
- Wertheim WA, "Osteomyelitis and intervertebral discitis caused by Pseudomonas pickettii", J Clin Microbiol, 30, pp.2506~2508 (1992)
- Sudo H, "Burkholderia pickettii spondylitis", Spinal Cord, 43, pp.499~502 (2005)
- Alfonso Olmos M, "Infected vertebroplasty due to uncommon bacteria solved surgically: a rare and threatening life complication of a common procedure: report of a case and a review of the literature", Spine, 31, pp.E770~E773 (2006)
- Weinstein L, "Cervical osteomyelitis caused by Burkholderia cepacia after rhinoplasty", J Infect Dev Ctries, 2, pp.76~77 (2008)
- Huang CH, "Characteristics of patients with Burkholderia cepacia bacteremia", J Microbiol Immunol Infect, 34, pp.215~219 (2001)
- Sader HS, "Antimicrobial susceptibility of uncommonly isolated non-enteric Gram-negative bacilli", Int J Antimicrob Agents, 25, pp.95~109 (2005)
- Lu DC, "In vitro activities of antimicrobial agents, alone and in combinations, against Burkholderia cepacia isolated from blood", Diagn Microbiol Infect Dis, 28, pp.187~191 (1997)
- Bonacorsi S, "Comparative in vitro activities of meropenem, imipenem, temocillin, piperacillin, and ceftazidime in combination with tobramycin, rifampin, or ciprofloxacin against Burkholderia cepacia isolates from patients with cystic fibrosis", Antimicrob Agents Chemother, 43, pp.213~217 (1999)
- Zimmerli W, "Clinical practice. Vertebral osteomyelitis", N Engl J Med, 362, pp.1022~1029 (2010)
- MacGregor RR, "pharmacokinetics and body fluid concentrations in patients receiving high-dose treatment for serious infections", Antimicrob Agents Chemother, 29, pp.188~192 (1986)
- Leigh DA, "Pharmacokinetic study of ceftazidime in bone and serum of patients undergoing hip and knee arthroplasty", J Antimicrob Chemother, 16, pp.637~642 (1985)
- Saux MC, "Bone diffusion of trimethoprim and sulfamethoxazole high pressure liquid chromatography(HPLC)", Pathol Biol, 30, pp.385~388 (1982)
- Lewin C, "In vitro activities of meropenem, PD 127391, PD 131628, ceftazidime, chloramphenicol, cotrimoxazole, and ciprofloxacin against Pseudomonas cepacia", Antimicrob Agents Chemother, 37, pp.123~125 (1993)