트리메토프림-설파메톡사졸 탈감작요법으로 치료에 성공한 Stenotrophomonas maltophilia 골수염 1예
Successful desensitization of trimethoprim-sulfamethoxazole in Stenostrophomonas maltophilia osteomyelitis
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초록
Stenotrophomonas maltophilia is an emerging pathogen associated with morbidity and mortality in hospitalized patients. The treatment of S. maltophilia infection is challenging because clinical isolates are frequently resistant to most antimicrobial agents except trimethoprim-sulfamethoxazole (TMP-SMX). S. maltophilia osteomyelitis is a rare disease and requires a prolonged treatment with TMP-SMX. Here, we report an interesting case of a patient with S. maltophilia osteomyelitis who developed a delayed hypersensitivity reaction during TMP-SMX treatment and successfully treated after desensitization. TMP-SMX desensitization should be considered in patients with hypersensitivity to TMP-SMX, especially when there are no effective alternative drugs in S. maltophilia infection.
Abstract
Stenotrophomonas maltophilia is an emerging pathogen associated with morbidity and mortality in hospitalized patients. The treatment of S. maltophilia infection is challenging because clinical isolates are frequently resistant to most antimicrobial agents except trimethoprim-sulfamethoxazole (TMP-SMX). S. maltophilia osteomyelitis is a rare disease and requires a prolonged treatment with TMP-SMX. Here, we report an interesting case of a patient with S. maltophilia osteomyelitis who developed a delayed hypersensitivity reaction during TMP-SMX treatment and successfully treated after desensitization. TMP-SMX desensitization should be considered in patients with hypersensitivity to TMP-SMX, especially when there are no effective alternative drugs in S. maltophilia infection.
참고문헌 (12)
- Denton M, "Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia", Clin Microbiol Rev, 11, pp.57~80 (1998)
- Absar N, "Desensitization to trimethoprim", sulfamethoxazole in HIV-infected patients, 1994, pp.93, 1001~1005
- Quirino T, "Desensitization to trimethoprim-sulfamethoxazole in patients infected with human immunodeficiency virus", Clin Infect Dis, 22, pp.396~ (1996)
- Jick H, "Adverse reactions to trimethoprim-sulfamethoxazole in hospitalized patients", Rev Infect Dis, 4, pp.426~428 (1982)
- Jung AC, "Management of adverse reactions to trimethoprim-sulfamethoxazole in human immunodeficiency virus-infected patients", Arch Intern Med, 154, pp.2402~2406 (1994)
- Lin D, "Cotrimoxazole for prophylaxis or treatment of opportunistic infections of HIV", AIDS in patients with previous history of hypersensitivity to cotrimoxazole, 2007, pp.2, CD005646~
- Yilmaz M, "Successfully treated nosocomial Stenotrophomonas maltophilia bacteremia following desensitization to trimethoprim-sulfamethoxazole", J Infect Chemother, 13, pp.122~123 (2007)
- Baltimore RS, "Puncture wound osteochondritis of the foot caused by Pseudomonas maltophilia", Pediatr Infect Dis J, 9, pp.143~144 (1990)
- Landrum ML, "Trimethoprim-sulfamethoxazole in the treatment of Stenotrophomonas maltophilia osteomyelitis", Clin Infect Dis, 40, pp.1551~1552 (2005)
- Gruchalla RS, "10. Drug allergy", J Allergy Clin Immunol, 111(2 Suppl), pp.S548~S559 (2003)
- Schnyder B, "Allergy to sulfonamides", J Allergy Clin Immunol, 131, pp.256.e1-5~257.e1-5 (2013)
- Teraki Y, "Successful desensitization to fixed drug eruption: the presence of CD25+CD4+ T cells in the epidermis of fixed drug eruption lesions may be involved in the induction of desensitization", Dermatology, 209, pp.29~32 (2004)