Absence of a Seasonal Variation of Hemorrhagic Fever with Renal Syndrome in Yeoncheon Compared to Nationwide Korea
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Background: Yeoncheon is an endemic region for hemorrhagic fever with renal syndrome (HFRS) and has been reporting HFRS cases intermittently in other seasons, including autumn. This study was conducted to determine whether a seasonal variation pattern of HFRS exists in Yeoncheon. Materials and Methods: From 2002 to 2016, raw data of the number of patients with HFRS in Yeoncheon and nationwide was collected from the Korea Center for Disease Control and Prevention. On the basis of the raw data, the incidence per 100,000 population was calculated for each month of the year. The twelve months were divided into four quarters, and the proportion of the disease by each quarter was calculated. The effects of sex, age, quarter, and time on HFRS occurrence were analyzed by Poisson regression analysis. Results: A total of 6,132 HFRS cases occurred nationwide, and 62 cases occurred in Yeoncheon. The incidence of the disease in Yeoncheon (9.07/100,000) was statistically higher than that nationwide (0.81/100,000). The quarterly incidence showed that occurrence proportion of HFRS was high in the third and fourth quarters (12.9%, 67.5%) nationwide, whereas it was relatively similar in all quarters in Yeoncheon (17.7%, 21.0%, 25.8%, 35.5%). The Poisson regression model showed that the relative risk of HFRS nationwide was 1.322 in the third quarter and 6.903 in the fourth quarter, but Yeoncheon had no risk increase by quarter. Conclusion: In this study, HFRS in Yeoncheon demonstrated no seasonal variation pattern compared to that in nationwide Korea, which may be considered a regional characteristic. Furthermore, in other regions where HFRS is endemic, like Yeoncheon, HFRS may arise regardless of seasonal variations.
Abstract
Background: Yeoncheon is an endemic region for hemorrhagic fever with renal syndrome (HFRS) and has been reporting HFRS cases intermittently in other seasons, including autumn. This study was conducted to determine whether a seasonal variation pattern of HFRS exists in Yeoncheon. Materials and Methods: From 2002 to 2016, raw data of the number of patients with HFRS in Yeoncheon and nationwide was collected from the Korea Center for Disease Control and Prevention. On the basis of the raw data, the incidence per 100,000 population was calculated for each month of the year. The twelve months were divided into four quarters, and the proportion of the disease by each quarter was calculated. The effects of sex, age, quarter, and time on HFRS occurrence were analyzed by Poisson regression analysis. Results: A total of 6,132 HFRS cases occurred nationwide, and 62 cases occurred in Yeoncheon. The incidence of the disease in Yeoncheon (9.07/100,000) was statistically higher than that nationwide (0.81/100,000). The quarterly incidence showed that occurrence proportion of HFRS was high in the third and fourth quarters (12.9%, 67.5%) nationwide, whereas it was relatively similar in all quarters in Yeoncheon (17.7%, 21.0%, 25.8%, 35.5%). The Poisson regression model showed that the relative risk of HFRS nationwide was 1.322 in the third quarter and 6.903 in the fourth quarter, but Yeoncheon had no risk increase by quarter. Conclusion: In this study, HFRS in Yeoncheon demonstrated no seasonal variation pattern compared to that in nationwide Korea, which may be considered a regional characteristic. Furthermore, in other regions where HFRS is endemic, like Yeoncheon, HFRS may arise regardless of seasonal variations.
참고문헌 (23)
- Schmaljohn CS, "Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome", Science, 227, pp.1041~1044 (1985)[DOI]
- LeDuc JW, "Epidemiology of Hantaan and related viruses", Lab Anim Sci, 37, pp.413~418 (1987)
- Lee HW, "Hemorrhagic fever with renal syndrome", Prog Med Virol, 36, pp.62~102 (1989)
- Tsai TF, "Hemorrhagic fever with renal syndrome: mode of transmission to humans", Lab Anim Sci, 37, pp.428~430 (1987)
- Lee HW, "Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats", J Infect Dis, 146, pp.638~644 (1982)[DOI]
- Lee HW, "Isolation of the etiologic agent of Korean hemorrhagic fever. 1978", J Infect Dis, 190, pp.1711~1721 (2004)[DOI]
- Lee HW, "Laboratory-acquired infections with Hantaan virus, the etiologic agent of Korean hemorrhagic fever", J Infect Dis, 146, pp.645~651 (1982)[DOI]
- Noh JY, "Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period", J Clin Virol, 58, pp.11~17 (2013)[DOI]
- 김호중, "Diagnostic challenge of hemorrhagic fever with renal syndrome (HFRS) on admission before its serological confirmation", Kidney Research and Clinical Practice, 23(1), pp.82~91 (2004), 대한신장학회
- Lee HW, "Hemorrhagic fever with renal syndrome in Korea", Rev Infect Dis, 11(Suppl 4), pp.S864~S876 (1989)
- Park JH, "A case-control study of risk factors for hemorrhagic fever with renal syndrome in Korean soldiers", Korean J Epidemiol, 16, pp.41~53 (1994)
- Yang CW, "Epidemiologic study of hemorrhagic fever with renal syndrome in Korean military: 1985-1990", Korean J Intern Med, 42, pp.802~808 (1992)
- 송준영, "Epidemiology of Hemorrhagic Fever with Renal Syndrome in Endemic Area of the Republic of Korea, 1995-1998", Journal of Korean Medical Science, 21(4), pp.614~620 (2006), 대한의학회
- Mills JN, "Potential influence of climate change on vector-borne and zoonotic diseases: a review and proposed research plan", Environ Health Perspect, 118, pp.1507~1514 (2010)[DOI]
- Ryou J, "Prevalence of hantavirus infection in wild rodents from five provinces in Korea, 2007", J Wildl Dis, 47, pp.427~432 (2011)[DOI]
- 이수한, "Epidemiology of Hemorrhagic Fever with Renal Syndrome in Korea, 2001-2010", Journal of Korean Medical Science, 28(10), pp.1552~1554 (2013), 대한의학회
- "Hemorrhagic fever with renal syndrome: statistical system of the national notifiable disease surveillance system (2002-2016)"[URL]
- "A comprehensive analysis of the population and household census (2008-2016)"[URL]
- Joshi YP, "The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study", BMC Infect Dis, 17, pp.406~ (2017)[DOI]
- Bi P, "Seasonal rainfall variability, the incidence of hemorrhagic fever with renal syndrome, and prediction of the disease in low-lying areas of China", Am J Epidemiol, 148, pp.276~281 (1998)[DOI]
- 2.0.CO;2,
- Klein TA, "Hantaan virus surveillance targeting small mammals at Dagmar North Training Area, Gyeonggi Province, Republic of Korea, 2001-2005", J Vector Ecol, 36, pp.373~381 (2011)[DOI]
- Klein TA, "Hantaan virus surveillance in small mammals at firing points 10 and 60, Yeoncheon, Gyeonggi Province, Republic of Korea", Vector Borne Zoonotic Dis, 12, pp.674~682 (2012)[DOI]