Seroprevalence of Severe Fever with Thrombocytopenia Syndrome in the Agricultural Population of Jeju Island, Korea, 2015–2017
0
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne zoonotic disease that is caused by the SFTS virus (SFTSV), and exhibits an overall mortality rate of approximately 20.0% in Korea. Most cases of this disease have been reported in Korea, East China, and Japan, and it mostly affects outdoor workers and farmers. This study aimed to investigate the seroprevalence of SFTSV among healthy farmers on Jeju Island, Korea. Materials and Methods: In this prospective cross-sectional study, we analyzed 421 blood samples obtained from 254 farmers (mean age, 59.9 years; 68.9% male) to determine the seroprevalence of SFTSV in 16 rural areas of the Jeju Special Self-Governing Province over a period of 3 years (January 2015–December 2017). We used an enzyme-linked immunosorbent assay to detect immunoglobulin (Ig) G antibodies against SFTSV in the collected samples. Results: The seroprevalence of the SFTSV IgG among farmers on Jeju Island was observed to be 2.4%. One subject showed seropositivity over the entire 3-year study period. The areas with the highest SFTSV IgG seropositivity rates were Seonheul-ri in Jocheon-eup, followed by Namwon-eup. Fruit farmers were at a higher risk of exposure to SFTSV than other farmers. Conclusion: The seroprevalence of SFTSV in the healthy agricultural population of Jeju Island was not high. However, personal hygiene management should be implemented for the agricultural population in the endemic areas. Surveillance of mild or asymptomatic infections is required in the endemic regions.
Abstract
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne zoonotic disease that is caused by the SFTS virus (SFTSV), and exhibits an overall mortality rate of approximately 20.0% in Korea. Most cases of this disease have been reported in Korea, East China, and Japan, and it mostly affects outdoor workers and farmers. This study aimed to investigate the seroprevalence of SFTSV among healthy farmers on Jeju Island, Korea. Materials and Methods: In this prospective cross-sectional study, we analyzed 421 blood samples obtained from 254 farmers (mean age, 59.9 years; 68.9% male) to determine the seroprevalence of SFTSV in 16 rural areas of the Jeju Special Self-Governing Province over a period of 3 years (January 2015–December 2017). We used an enzyme-linked immunosorbent assay to detect immunoglobulin (Ig) G antibodies against SFTSV in the collected samples. Results: The seroprevalence of the SFTSV IgG among farmers on Jeju Island was observed to be 2.4%. One subject showed seropositivity over the entire 3-year study period. The areas with the highest SFTSV IgG seropositivity rates were Seonheul-ri in Jocheon-eup, followed by Namwon-eup. Fruit farmers were at a higher risk of exposure to SFTSV than other farmers. Conclusion: The seroprevalence of SFTSV in the healthy agricultural population of Jeju Island was not high. However, personal hygiene management should be implemented for the agricultural population in the endemic areas. Surveillance of mild or asymptomatic infections is required in the endemic regions.
참고문헌 (22)
- Liu Q, "Severe fever with thrombocytopenia syndrome, an emerging tickborne zoonosis", Lancet Infect Dis, 14, pp.763~772 (2014)
- Liu Q, "Severe fever with thrombocytopenia syndrome, an emerging tickborne zoonosis", Lancet Infect Dis, 14, pp.763~772 (2014)
- Park SW, "Epidemiological and clinical features of severe fever with thrombocytopenia syndrome during an outbreak in South Korea, 2013-2015", Am J Trop Med Hyg, 95, pp.1358~1361 (2016)
- Li Z, "Increased prevalence of severe fever with thrombocytopenia syndrome in Eastern China clustered with multiple genotypes and reasserted virus during 2010-2015", Sci Rep, 7, pp.6503~ (2017)
- Park SW, "Prevalence of severe fever with thrombocytopenia syndrome virus in Haemaphysalis longicornis ticks in South Korea", Ticks Tick Borne Dis, 5, pp.975~977 (2014)
- Kato H, "SFTS epidemiological research group-Japan. Epidemiological and clinical features of severe fever with thrombocytopenia syndrome in Japan, 2013-2014", PLoS One, 11, pp.e0165207~ (2016)
- 유정래, "Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome", The Korean Journal of Internal Medicine, 34(4), pp.902~909 (2019), 대한내과학회[DOI]
- "Infectious Disease Surveillance 2017, Public Health Weekly Report" (2017)[URL]
- Kim WY, "Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea", Clin Infect Dis, 60, pp.1681~1683 (2015)
- Yoo JR, "Family cluster analysis of severe fever with thrombocytopenia syndrome virus infection in Korea", Am J Trop Med Hyg, 95, pp.1351~1357 (2016)
- Yoo JR, "Surveillance results for family members of patients with severe fever with thrombocytopenia syndrome", Zoonoses Public Health, 65, pp.903~907 (2018)
- Ni H, "Apodemus agrarius is a potential natural host of severe fever with thrombocytopenia syndrome(SFTS)-causing novel bunyavirus", J Clin Virol, 71, pp.82~88 (2015)
- Hayasaka D, "Seroepidemiological evidence of severe fever with thrombocytopenia syndrome virus infections in wild boars in Nagasaki, Japan", Trop Med Health, 44, pp.6~ (2016)
- Li P, "Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis", PLoS One, 12, pp.e0175592~ (2017)
- Liu K, "Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China", PLoS Negl Trop Dis, 8, pp.e2820~ (2014)
- Gokuden M, "Low seroprevalence of severe fever with thrombocytopenia syndrome virus antibodies in individuals living in an endemic area in Japan", Jpn J Infect Dis, 24, pp.225~228 (2018)
- Han MA, "Seroprevalence of severe fever with thrombocytopenia syndrome virus antibodies in rural areas, South Korea", Emerg Infect Dis, 24, pp.872~874 (2018)
- Li Z, "Seroprevalence of antibodies against SFTS virus infection in farmers and animals, Jiangsu, China", J Clin Virol, 60, pp.185~189 (2014)
- Qi R, "Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study", Epidemiol Infect, 147, pp.e78~ (2019)
- Zhang X, "An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV", Sci China Life Sci, 56, pp.697~700 (2013)
- Shin J, "Characteristics and factors associated with death among patients hospitalized for severe fever with thrombocytopenia syndrome, South Korea, 2013", Emerg Infect Dis, 21, pp.1704~1710 (2015)
- Huang YT, "Neutralizing antibodies to severe fever with thrombocytopenia syndrome virus 4 years after hospitalization, China", Emerg Infect Dis, 22, pp.1985~1987 (2016)