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급성 사람면역결핍바이러스 감염에 의한 뇌염 1예

Encephalitis due to Acute Human Immunodeficiency Virus Infection

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초록

Clinical presentations associated with acute human immunodeficiency virus (HIV)infection are various and nonspecific. Neurologic manifestations may accompany acute HIV infection. Aseptic meningitis has been described in several reports;however, acute encephalitis during acute HIV infection is rare. Some studies have suggested that antiretroviral therapy for treatment of symptomatic acute HIV infection could be beneficial, especially in severe cases. Encephalitis is lifethreatening;therefore, early diagnosis and antiretroviral therapy may be needed. We report on a case of encephalitis associated with acute HIV infection. The patient received early antiretroviral therapy and recovered from encephalitis without neurological sequelae.ㅎ

Abstract

Clinical presentations associated with acute human immunodeficiency virus (HIV)infection are various and nonspecific. Neurologic manifestations may accompany acute HIV infection. Aseptic meningitis has been described in several reports;however, acute encephalitis during acute HIV infection is rare. Some studies have suggested that antiretroviral therapy for treatment of symptomatic acute HIV infection could be beneficial, especially in severe cases. Encephalitis is lifethreatening;therefore, early diagnosis and antiretroviral therapy may be needed. We report on a case of encephalitis associated with acute HIV infection. The patient received early antiretroviral therapy and recovered from encephalitis without neurological sequelae.ㅎ

참고문헌 (11)

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  3. Daar ES., "Diagnosis of primary HIV-1 infection. Los Angeles County Primary HIV Infection Recruitment Network", Ann Intern Med, 134, pp.25~29 (2001)
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  7. Brenner BG., "High rates of forward transmission events after acute", early HIV-1 infection, 2007, pp.195, 951~959
  8. Wawer MJ., "Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda", J Infect Dis, 191, pp.1403~1409 (2005)
  9. Bell SK., "Clinical management of acute HIV infection: best practice remains unknown", J Infect Dis, 202, pp.S278~S288 (2010)
  10. Boufassa F., "Influence of neurologic manifestations of primary human immunodeficiency virus infection on disease progression. SEROCO Study Group", J Infect Dis, 171, pp.1190~1195 (1995)
  11. Letendre S., "Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system", Arch Neurol, 65, pp.65~70 (2008)

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