대사증후군과 혈액학적 지표와의 연관성
Association Between Metabolic Syndrome and Hematologic Parameters
1
조회
0
다운로드
8
인용
0
참고문헌
키워드
초록
연구배경: 대사증후군에서는 심혈관계 질환의 위험이 증가하는데, 이는 염증성 싸이토카인과 혈전생성 요소의 활성화가 원인으로 알려져 있다. 이에 본 연구에서는 혈액의 점성 또는 염증상태를 반영하는 적혈구 수•용적률, 혈색소 농도, 백혈구수 및 분획들과 대사증후군과의 관계를 살펴보고자 한다. 방법: 일개 대학병원의 건강검진 수진자 399명 중 과거력과 흡연력에 대한 설문조사를 시행한 313명 중에서 전혈구 계산수치가 정상 참고범위에 포함되는 299명(남자 137명, 여자 162명)을 대상으로 하여 대사증후군과 혈액학적 지표들과의 연관성을 분석하였다. 결과: 연령, 성별, 흡연상태를 보정한 후 대사증후군 환자에서 적혈구수 및 총백혈구수가 많았으며(P<0.05), 특히 남성 대사증후군 환자에서 총백혈구수, 중성구수, 임파구수가 많았다(P<0.05). 대사증후군 구성요소의 개수에 따라 구성요소를 하나도 가지지 않는 군에서 4개 이상 가진 군까지 각 5개의 군으로 나누어서 분석시 남자에서 총백혈구수, 중성구수, 임파구수의 차이가 유의한 것으로 나타났으며(P<0.05). 그리고 대사증후군의 구성요소의 개수가 증가함에 따라 총백혈구•중성구•임파구 수가 증가하는 경향을 나타내었다(P<0.01). 결론: 적혈구와 백혈구의 수는 대사증후군 환자에서 증가되어 있으며 특히 남자 대사증후군 환자에서 총백혈구수 및 백혈구 분획인 중성구수와 임파구수가 증가하였고 대사증후군의 구성요소의 개수가 많아질수록 총백혈구수, 중성구수, 임파구수가 증가였다.
Abstract
Background: Metabolic syndrome increases the risk of cardiovascular events as a result of the activation of inflammatory cytokines and thrombogenic factors. In this study, we investigated whether metabolic syndrome (MS) is related to red blood cell (RBC), white blood cell(WBC) and differential counts. Methods: We analyzed 399 subjects who participated in routine health check up from March to July 2004. 299 subjects whose hematologic parameters were within normal value were included finally. We measured their metabolic components and evaluated the relation of MS and hematologic parameters. Results: All results were adjusted for gender, age and smoking status. The counts of RBC and WBC were significantly higher in MS group(P<0.05), and especially the counts of WBC, neutrophil, and lymphocyte were higher in the male MS group. According to the number of metabolic component(0,1,2,3 and more than 4) the subjects were allocated in 5 groups. Especially, only in men the means of the counts of WBC, neutrophil, and lymphocyte were different significantly among these groups(P<0.05). As the number of metabolic component was increased, WBC, neutrophil, and lymphocyte were increased significantly(P<0.01). Conclusions: The metabolic syndrome is related to the counts of RBC and WBC, especially in male MS group, the counts of WBC, neutrophil, lymphocyte were higher. In men as the number of metabolic component was increased, the counts of WBC, neutrophil and lymphocyte were increased and there was the significant difference of them among the groups which were divided according to the number of metabolic component.
참고문헌 (27)
- "^Important death cause inKorea^Available from" (2005)
- "Third Report of the National Cholesterol Education Program Expert Panel on Detection and Treatment of HighBlood Cholesterol in Adults", 106((25), pp.3143~421 (2002)
- "Cardiovascular morbidity and mortality associated with themetabolic syndrome", 24(4), pp.683~9 (2001)
- "Relationship of metabolic syndrome and fibrinolytic dysfunction tocardiovascular disease", 108(4), pp.420~5 (2003)
- "Insulin resistance and inflammation inan evolutionary perspective:the contribution of cytokinegenotype", phenotype to thriftiness, 1999, pp.42(11), 1367~74
- "Is type II diabetes mellitus a disease of theinnate immune system?", 41((10), pp.1241~8 (1998)
- "The Asia-Pacific Perspective: Redefining Obesity and Its Treatment.", pp.1~55, World Health Organization
- "New aspects of the insulin resistance syndrome:impact onhaematological parameters", 44(10), pp.1232~7 (2001)
- "Natural and biosyntheticinsulin stimulates the growth of human erythroid progenitors invitro", 55(6), pp.1209~11 (1982)
- "Insulinstimulates cord blood erythroid progenitor growth:evidence for anaetiological role in neonatal polycythaemia", 64(3), pp.503~11
- "Relationship between hemoglobin andcardiovascular risk factors in young adults", 46(11), pp.1257~66
- "Hematocrit andhemoglobin are independently related to insulin resistance andcompensatory hyperinsulinemia in healthy", ;47((7)), pp.831~5 (1998)
- "Stimulatory effect of human insulin on erythroid progenitors in human CD34+ separated bone marrow cells andthe relationship between insulin and erythropoietin", pp.329~38
- "Hemorheological aspects of themetabolic syndrome markers of insulin resistanceobesity orhyperinsulinemia?", 30((3-), pp.203~9 (2004)
- "release fromerythrocytes flowing in a narrow O", 281()(1), pp.H448~56
- "Reduced oxygenrelease from erythrocytes by the acceleration-induced flow shift observed in an oxygen-permeable narrow tube", 35((9), pp.1241~51 (2002)
- "Modulation of endothelial nitric oxide synthase expression by redblood cell aggregation", 286(1), pp.~9 (2004)
- "Effect oferythrocyte aggregation on velocity profiles in venules", 280(1), pp.~36 (2001)
- "White blood cell count is associated with some features ofmetabolic syndrome in a very old population", 11(4), pp.221~6 (2001)
- "Association of white blood cell count and clusteredcomponents of metabolic syndrome in Japanese men", 68(10), pp.892~7 (2004)
- "Leukocyte counts and coronary heart disease in aJapanese cohort", 116(3), pp.496~509 (1982)
- "Association of lymphocyte sub-populations with clusteredfeatures of metabolic syndrome in middle-aged Japanese men", 173(2), pp.295~300 (2004)
- "Disorders of granulocytes and monocytes" (2004)
- "The protective effects of estrogen on the cardiovascular sysem", 340, pp.1801~1811 (1999)
- "Smoking status and differential white cellcount in men and women in the EPIC-Norfolk population", 169(2), pp.331~7 (2003)
- "Longitudinal relation between smoking and white blood cells", 144(8), pp.734~41 (1996)
- "TheAssociation between White Blood Cell Counts and ClusteredFeatures of the Metabolic Syndrome", ;25((01), pp.34~9 (2004)