한국 성인에서 대사증후군과 요산/크레아티닌 비와의 연관성: 2016년 국민건강영양조사 자료를 이용하여
Relationship between Metabolic Syndrome and Uric Acid to Creatinine Ratio in Korean Adults: Korea National Health and Nutrition Examination Survey 2016
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초록
연구배경: 대사증후군과 혈중 요산 수치와의 연관성은 밝혀졌지만 요산/크레아티닌 비와의 연관성을 본 국내 연구는없다. 이에 본 연구에서는 국민건강영양조사 자료를 활용하여 대사증후군과 요산/크레아티닌 비와의 연관성을 보았다. 방법: 건강한 19세 이상 성인을 대상으로 대사증후군 각항목 및 대사증후군 유무를 독립변수로 요산/크레아티닌비를 종속변수로 선정하여 혼란변수를 보정한 후 complex sample logistic regression test를 이용하여 분석하였다. 결과: 수축기혈압은 1.143 (95% CI, 1.051-1.243; P=0.002), 이완기혈압은 1.144 (95% CI, 1.054-1.241; P=0.001), 공복시혈당은 1.166 (95% CI, 1.070-1.271; P<0.001), 중성지방은1.340 (95% CI, 1.259-1.427; P<0.001), 고밀도콜레스테롤은1.163 (95% CI, 1.100-1.230; P<0.001), 허리둘레는 1.342 (95% CI, 1.239-1.455; P<0.001), 대사증후군의 유무는 1.041 (95% CI, 1.034-1.049; P≤0.001)로 요산/크레아티닌 비와 양의 상관관계를 보였다. 결론: 본 연구는 요산/크레아티닌 비와 대사증후군 유무및 각 요소와는 유의한 상관관계를 보여주고 이는 한국인을대상으로 한 첫 연구임에 의미가 있다
Abstract
Background:While the correlation between metabolic syndrome (MS) and serum uric acid (sUA) levels has already been identified, the correlation between MS and the sUA/creatinine ratio has not been studied in Korea. Accordingly, the present study examined the correlation between MS and the sUA/creatinine ratio using data from the seventh Korea National Health and Nutrition Examination Survey (2016). Methods:The study population consisted of healthy adults aged 19 years or older medical diseases. The five components of MS and the presence of MS were used as independent variables, while the sUA/creatinine ratio was selected as the dependent variable. After adjusting for confounding variables, a complex samples logistic regression test was performed to analyze the correlations between the sUA/creatinine ratio and MS and its components. Results:The following variables showed positive correlation with the sUA/creatinine ratio: systolic blood pressure (BP) (95% confidence interval [CI], 1.051-1.243; P=0.002), diastolic BP 1.144 (95% CI, 1.054-1.241; P=0.001), fasting blood sugar level 1.166 (95% CI, 1.070-1.271; P<0.001), triglyceride level 1.340 (95% CI, 1.259-1.427; P<0.001), high density lipoprotein level 1.163 (95% CI, 1.100-1.230; P<0.001), waist circumference 1.342 (95% CI, 1.239-1.455; P<0.001), and the presence of MS 1.041 (95% CI, 1.034-1.049; P≤0.001). Conclusions:The findings of the present study demonstrated a statistically significant correlation between the sUA/creatinine ratio and the presence of MS as well as with each component of MS. The significance of the present study is that it is the first study to investigate Koreans.
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