건강한 한국 성인 남성에서 골밀도와 중성지방의 상관관계
Relationship between Triglyceride and Bone Mineral Density in Healthy Korean Men
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연구배경: 노인 질환의 증가로 골다공증, 고지혈증 및 심혈관 질환에 대한 관심이 증가되었다. 이런 흐름에 따라 골밀도와 고지혈증의 상관관계에 대한 여러 연구가 시행되어왔다. 그러나 지금까지 그 연구 결과가 일치하지 않고, 대부분의 연구가 여성에게 편중되어 있었다. 따라서 본 연구에서는 건강한 한국 남성을 대상으로 혈청 지질 농도와 골밀도 간의 상관관계에 대하여 알아보고자 하였다. 방법: 일개 대학병원 검진센터를 방문한 성인 남성 851 명을 대상으로 설문지를 통하여 흡연, 음주력, 고혈압, 당뇨병 등의 과거력을 조사하였고, 검사실 검사로 총 콜레스테롤, 중성지방, 저밀도지단백 콜레스테롤, 고밀도지단백콜레스테롤, 아포지단백 A-1, 아포지단백 B를 측정하였으며, 골밀도는 이중 에너지 X선 흡수 계측법을 이용하여 요추 골밀도와 대퇴목 골밀도, 대퇴골 골밀도를 측정하였다. 결과: 체질량지수와 골밀도 T 값은 양의 상관관계를 보였다. 중성지방은 골밀도 T 값과 양의 상관관계를 보였으며 나이와 체질량지수를 보정한 이후에도 유의한 양의 상관관계를 보였다. 고밀도지단백 콜레스테롤은 골밀도와 음의 상관관계를 보였으나 나이와 체질량지수를 보정한 이후에는 유의한 상관관계가 없었다. 저밀도지단백 콜레스테롤은 골밀도와 상관관계가 없었다. 결론: 한국인 성인 남성에서 중성지방이 높을수록 모든부위의 골밀도가 유의하게 증가하였음을 확인할 수 있었다. 총 콜레스테롤과 고밀도지단백 콜레스테롤 및 저밀도지단백 콜레스테롤은 골밀도와 유의한 상관관계가 없었다
Abstract
Background: As the elderly population increasing, the interest in osteoporosis, hyperlipidemia, and cardiovascular diseases has increased in recent years. In accordance with such trend, many studies regarding correlations between bone density and hyperlipidemia have been conducted. However, the study outcomes have been inconsistent so far, and most of the studies focused on females. Therefore, this study aimed to investigate the correlation between serum lipid levels and bone density in healthy Korean male adults. Methods: This study surveyed 851 male adults, who visited an examination center at a university hospital, on smoking, drinking, hypertension, and diabetes history. A laboratory examination measured total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, apolipoprotein A-1, and apolipoprotein B. For bone density, lumbar, femoral neck, and femur were measured using dual energy X-ray absorptiometry. Results: Body mass index (BMI) and bone density T-value showed a positive correlation. Triglyceride exhibited a positive correlation with bone density T-value, and they still revealed a significant positive correlation after correcting for age and BMI. While high density lipoprotein cholesterol showed a negative correlation with bone density, they were not correlated significantly after correcting for age and BMI. There was no correlation found between low density lipoprotein cholesterol and bone density. Conclusions: This study confirmed that bone densities of all areas measured were significantly increased in Korean male adults as triglyceride increased. Total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol did not show a significant correlation with bone density.
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