한국 성인 남성의 신체표현형에 따른 골감소증 및 골다공증 발생 위험 평가: 지역사회기반 코호트 10년 자료분석
Risk Assessment of the Incidence of Osteopenia and Osteoporosis according to Body Size Phenotype in Korean Adults Men: Analysis of 10-Years Community-Based Cohort Data
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Purpose: We evaluated the impact of body size phenotypes in Korean adult men on incidence of osteopenia and osteoporosis using data from the Korean Genome and Epidemiology Study (KoGES). Methods: Bone mineral densities at the femoral neck and lumbar spine were assessed using dual-energy X-ray absorptiometry. We analyzed the baseline occurrence of osteopenia and osteoporosis from 2001 to 2002, and during the follow-up period from 2011 to 2012. Odds ratios (ORs) of osteopenia and osteoporosis for each body size phenotype were analyzed using a logistic regression model. Results: In total, 2,769 participants without osteopenia and osteoporosis at baseline were included in this national cohort study using KoGES community-based(Ansan/Ansung) data. The respective ORs (95% CIs) for osteopenia and osteoporosis were 1.29 (95% CI 1.09-1.53, p<.001) metabolically abnormal obesity (MAO) compared to metabolically healthy normal weight (MHNW). The ORs (95% CIs) for osteopenia and osteoporosis were 1.42 (95% CI 1.21~1.66, p<.001) in the obesity group, 1.16 (95% CI 1.02~1.32, p=.025) in the hypertriglyceridemia group, and 1.32 (95% CI 1.16~1.50, p<.001) in the hypertension group. Conclusion: Metabolically abnormal obesity (MAO) in males increase the risk of osteopenia and osteoporosis compared with Metabolically healthy normal weight (MHNW). Management of obesity and metabolic syndrome should be considered in patient plans to prevent osteopenia and osteoporosis.
Abstract
Purpose: We evaluated the impact of body size phenotypes in Korean adult men on incidence of osteopenia and osteoporosis using data from the Korean Genome and Epidemiology Study (KoGES). Methods: Bone mineral densities at the femoral neck and lumbar spine were assessed using dual-energy X-ray absorptiometry. We analyzed the baseline occurrence of osteopenia and osteoporosis from 2001 to 2002, and during the follow-up period from 2011 to 2012. Odds ratios (ORs) of osteopenia and osteoporosis for each body size phenotype were analyzed using a logistic regression model. Results: In total, 2,769 participants without osteopenia and osteoporosis at baseline were included in this national cohort study using KoGES community-based(Ansan/Ansung) data. The respective ORs (95% CIs) for osteopenia and osteoporosis were 1.29 (95% CI 1.09-1.53, p<.001) metabolically abnormal obesity (MAO) compared to metabolically healthy normal weight (MHNW). The ORs (95% CIs) for osteopenia and osteoporosis were 1.42 (95% CI 1.21~1.66, p<.001) in the obesity group, 1.16 (95% CI 1.02~1.32, p=.025) in the hypertriglyceridemia group, and 1.32 (95% CI 1.16~1.50, p<.001) in the hypertension group. Conclusion: Metabolically abnormal obesity (MAO) in males increase the risk of osteopenia and osteoporosis compared with Metabolically healthy normal weight (MHNW). Management of obesity and metabolic syndrome should be considered in patient plans to prevent osteopenia and osteoporosis.