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잔소리졸 함유 껌의 치태 및 치은염 억제 효과

Effect of Curcuma Xanthorrhiza containing gum on reduction of the plaque and the gingivitis

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초록

The purpose of the present study was to determine the effect of a chewing gum containing 70% xylitol and 0.23% Curcuma xanthorrhiza extract to remove dental plaque and reduce gingivitis when used as a supplement to daily toothbrushing for 3 weeks. The study group consisted of 75 adults with moderate gingivitis. Participants were divided into 3 groups(control 1 group – Gum base, control 2 group – 70% Xylitol, experiment group – 70% xylitol and 0.23% xanthorrhizol) and instructed to chew the study gum for 3 times daily for 3 weeks in addition to regular daily toothbrushing. Chewing xylitol/xanthorrhizol gum significantly reduced plaque index with significant difference by week 3(p<0.01). Gingival index and bleeding on probing were decreased in xylitol/ Curcuma xanthorrhiza extract group by 35.9% and 31.65% each in the same period. No adverse effects on the oral tissues were observed in any of the participants for the duration of the study. In conclusion, regular use of a chewing gum containing 70% xylitol and 0.23% Curcuma xanthorrhiza extract appears safe and effective for the removal of dental plaque and reduction of gingivitis when used in conjunction with daily toothbrushing.

Abstract

The purpose of the present study was to determine the effect of a chewing gum containing 70% xylitol and 0.23% Curcuma xanthorrhiza extract to remove dental plaque and reduce gingivitis when used as a supplement to daily toothbrushing for 3 weeks. The study group consisted of 75 adults with moderate gingivitis. Participants were divided into 3 groups(control 1 group – Gum base, control 2 group – 70% Xylitol, experiment group – 70% xylitol and 0.23% xanthorrhizol) and instructed to chew the study gum for 3 times daily for 3 weeks in addition to regular daily toothbrushing. Chewing xylitol/xanthorrhizol gum significantly reduced plaque index with significant difference by week 3(p<0.01). Gingival index and bleeding on probing were decreased in xylitol/ Curcuma xanthorrhiza extract group by 35.9% and 31.65% each in the same period. No adverse effects on the oral tissues were observed in any of the participants for the duration of the study. In conclusion, regular use of a chewing gum containing 70% xylitol and 0.23% Curcuma xanthorrhiza extract appears safe and effective for the removal of dental plaque and reduction of gingivitis when used in conjunction with daily toothbrushing.

참고문헌 (40)

  1. Listgarten MA, "The structure of dental plaque", Periodontol 2000, 5, pp.52~65 (1994)
  2. Marsh PD, "Microbiologic aspects of dental plaque and dental caries", Dent Clin North Am, 43, pp.599~614 (1999)
  3. Cancro LP, "The expected effect on oral health of dental plaque control through mechanical removal", Periodontol 2000, 8, pp.60~74 (1995)
  4. Westfelt E, "The effect of supragingival plaque control on the progression of advanced periodontal disease", J Clin Periodontol, 25, pp.536~41 (1998)
  5. 정예진, "치태제거 및 치은염증에 대한 실리콘 칫솔의 효과", 대한치주과학회지, 30, pp.911~923 (2000)
  6. Waerhaug J, "Effect of toothbrushing on subgingival plaque formation", J Periodontol, 52, pp.30~4 (1981)
  7. 진미성, "자몽종차주출물과 자일리톨이 배합된 껌의 치은염 예방 및 항균효과", 대한치주과학회지, 33, pp.485~497 (2003)
  8. Hanham A, "The effect of chewing sugarfree gum on plaque regrowth at smooth and occlusal surfaces", J Clin Periodontol, 28, pp.255~7 (2001)
  9. Itthagarun A, "Chewing gum and saliva in oral health", J Clin Dent, 8, pp.159~62 (1997)
  10. Hoerman KC, "Effect of gum chewing on plaque accumulation", J Clin Dent, 2, pp.17~21 (1990)
  11. Addy M, "Effects of sugared and sugar-free chewing gum on the accumulation of plaque and debris on the teeth", J Clin Periodontol, 9, pp.346~54 (1982)
  12. Isokangas P, "Xylitol chewing gum in caries prevention: a field study in children", J Am Dent Assoc, 117, pp.315~20 (1988)
  13. Steinberg LM, "Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gum", Clin Prev Dent, 14, pp.31~4 (1992)
  14. Leach SA, "Reversal of fissure caries in the albino rat by sweetening agents", Caries Res, 15, pp.508~11 (1981)
  15. "Z Naturforsch B", 1970, 995~8
  16. H. R, "Xanthorrhizol, a new sesquiterpene from Curcuma xanthorrhiza", Z Naturforsch B, 25, pp.995~998 (1970)
  17. Tumeric, "Javanese Curcumae xanthorizae rhizoma", European Pharmacopoeia-Supplement, pp.1557~1558 (2001)
  18. Cheah YH, "Xanthorrhizol exhibits antiproliferative activity on MCF-7 breast cancer cells via apoptosis induction", Anticancer Res, 26, pp.4527~34 (2006)
  19. Itokawa H, "Studies on the antitumor bisabolane sesquiterpenoids isolated from Curcuma xanthorrhiza", Chem Pharm Bull(Tokyo), 33, pp.3488~3492 (1985)
  20. Ismail N, "Xanthorrhizol induces apoptosis via the upregulation of bax and p53 in HeLa cells", Anticancer Res, 25, pp.2221~2227 (2005)
  21. Itokawa H, "Studies on the antitumor bisabolane sesquiterpenoids isolated from Curcuma xanthorrhiza", Chem Pharm Bull (Tokyo), 33, pp.3488~92 (1985)
  22. Yasni S, "Identification of an active principle in essential oils and hexanesoluble fractions of Curcuma xanthorrhizaROXB. Showing triglyceride lowering action in rats", Food Chem Toxicol, 32, pp.273~278 (1994)
  23. Lin SC, "Protective and therapeutic effects of Curcuma xanthorrhiza on hepatotoxin-induced liver damage", Am J Chin Med, 23, pp.243~54 (1995)
  24. Kim SH, "Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity in mice", Food Chem Toxicol, 43, pp.117~22 (2005)
  25. Claeson P, "Three non-phenolic diarylheptanoids with antiinflammatory activity from Curcuma xanthorrhiza", Planta Med, 59, pp.451~4 (1993)
  26. Claeson P, "Non-phenolic linear diarylheptanoids from Curcuma xanthorrhiza: a novel type of topical antiinflammatory agents: structure-activity relationship", Planta Med, 62, pp.236~40 (1996)
  27. Lee SK, "Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells", J Environ Pathol Toxicol Oncol, 21, pp.141~8 (2002)
  28. Ozaki Y, "Antiinflammatory effect of Curcumaxanthorrhiza Roxb, and its active principles", Chem Pharm Bull (Tokyo), 38, pp.1045~8 (1990)
  29. Choi MA, "Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in experimental mouse lung metastasis model", Biochem Biophys Res Commun, 326, pp.210~7 (2005)
  30. Hwang JK, "Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens", Fitoterapia, 71, pp.321~3 (2000)
  31. Hwang JK, "Xanthorrhizol: a potential antibacterial agent from Curcuma xanthorrhiza against Streptococcus mutans", Planta Med, 66, pp.196~7 (2000)
  32. 홍지연, "천연추출물 Curcuma xanthorriza oil 함유치약의 치태 및 치은염 억제효과", 대한치주과학회지, 35(4), pp.1053~1072 (2005), 대한치주과학회
  33. Loe H, "Periodontal Disease in Pregnancy. I. Prevalence and Severity", Acta Odontol Scand, 21, pp.533~51 (1963)
  34. Bosman CW, "The reversal of localized experimental gingivitis. A comparison between mechanical toothbrushing procedures and a 0.2% chlorhexidine mouthrinse", J Clin Periodontol, 4, pp.161~72 (1977)
  35. 김백일, "Curcuma xanthorrhiza 추출물 및 함유 치약의 구취 억제 효과와 구강 유해균에 대한 선택적 항균 효과", 대한구강보건학회지, 29(2), pp.222~237 (2005), 대한구강보건학회
  36. 김백일, "Curcuma xanthorrhiza oil이 함유된 구강분무액의 구취감소효과에 관한 임상적 연구", 대한구강보건학회지, 30(1), pp.75~84 (2006), 대한구강보건학회
  37. 황수정, "Curcuma xanthorrhiza oil 및 죽염배합세치제의 치은염억제효과", 대한구강보건학회지, 29(4), pp.451~462 (2005), 대한구강보건학회
  38. Scheinin A, "Xylitol and caries: the collaborative WHO oral disease preventive programme in Hungary", Int Dent J, 35, pp.50~7 (1985)
  39. Scheinin A, "Collaborative WHO xylitol field studies in Hungary. I. Three-year caries activity in institutionalized children", Acta Odontol Scand, 43, pp.327~47 (1985)
  40. Nuuja T, "Xylitol and the bactericidal effect of chlorhexidine and fluoride on Streptococcus mutans and Streptococcus sanguis", Acta Odontol Scand, 51, pp.109~14 (1993)

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