Melanin bleaching and melanogenesis inhibition effects of Pediococcus acidilactici PMC48 isolated from Korean perilla leaf kimchi
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Overproduction and accumulation of melanin in the skin will darken the skin and cause skin disorders. So far, components that can inhibit tyrosinase, a melanin synthase of melanocytes, have been developed and used as ingredients of cosmetics or pharmaceutical products. However, most of existing substances can only inhibit the biosynthesis of melanin while melanin that is already synthesized and deposited is not directly decomposed. Thus, their effects in decreasing melanin concentration in the skin are weak. To overcome the limitation of existing therapeutic agents, we started to develop a substance that could directly biodegrade melanin. We screened traditional fermented food microorganisms for their abilities to direct biodegrade melanin. As a result, we found that a kimchi-derived Pediococcus acidilactici PMC48 had a direct melanin-degrading effect. This PMC48 strain is a new strain, different from P. acidilactici strains reported so far. It not only directly degrades melanin, but also has tyrosinase-inhibiting effect. It has a direct melanindecomposition effect. It exceeds existing melanin synthesis-inhibiting technology. It is expected to be of high value as a raw material for melanin degradation drugs and cosmetics.
Abstract
Overproduction and accumulation of melanin in the skin will darken the skin and cause skin disorders. So far, components that can inhibit tyrosinase, a melanin synthase of melanocytes, have been developed and used as ingredients of cosmetics or pharmaceutical products. However, most of existing substances can only inhibit the biosynthesis of melanin while melanin that is already synthesized and deposited is not directly decomposed. Thus, their effects in decreasing melanin concentration in the skin are weak. To overcome the limitation of existing therapeutic agents, we started to develop a substance that could directly biodegrade melanin. We screened traditional fermented food microorganisms for their abilities to direct biodegrade melanin. As a result, we found that a kimchi-derived Pediococcus acidilactici PMC48 had a direct melanin-degrading effect. This PMC48 strain is a new strain, different from P. acidilactici strains reported so far. It not only directly degrades melanin, but also has tyrosinase-inhibiting effect. It has a direct melanindecomposition effect. It exceeds existing melanin synthesis-inhibiting technology. It is expected to be of high value as a raw material for melanin degradation drugs and cosmetics.
참고문헌 (30)
- Sarangarajan R, "The polymerization of melanin : a poorly understood phenomenon with egregious biological implications", Melanoma Res, 16, pp.3~10 (2006)
- Riley PA, "Melanin", Int. J. Biochem. Cell Biol, 29, pp.1235~1239 (1997)
- Matts PJ, "The distribution of melanin in skin determined in vivo", Br. J. Dermatol, 156, pp.620~628 (2007)
- Costin GE, "Human skin pigmentation : melanocytes modulate skin color in response to stress", FASEB J, 21, pp.976~994 (2007)
- Brenner M, "The protective role of melanin against UV damage in human skin", Photochem. Photobiol, 84, pp.539~549 (2008)
- Ortonne JP, "Melanin pigmentary disorders : treatment update", Dermatol. Clin, 23, pp.209~226 (2005)
- Gimenez Garcia RM, "Drug-Induced hyperpigmentation : Review and case series", J. Am. Board Fam. Med, 32, pp.628~638 (2019)
- Rendon M, "Treatment of melasma", J. Am. Acad. Dermatol, 54, pp.S272~S281 (2006)
- Rendon MI, "Hyperpigmentation disorders in hispanic population in the United States", J. Drugs Dermatol, 18, pp.s112~s114 (2019)
- Jozefa Friedrich, "Production of Melanin Bleaching Enzyme of Fungal Origin and Its Application in Cosmetics", Biotechnology and Bioprocess Engineering, 12(3), pp.200~206 (2007), 한국생물공학회
- Kim BS, "Purification and characterization of a melanin biodegradation enzyme from Geotrichum sp", Int. J. Cosmet. Sci, 38, pp.622~626 (2016)
- Luther JP, "Degradation of melanin by Aspergillus fumigatus", Appl. Environ. Microbiol, 40, pp.145~155 (1980)
- Awong-Taylor J, "Comparison of biochemical and molecular methods for the identification of bacterial isolates associated with failed loggerhead sea turtle eggs", J. Appl. Microbiol, 104, pp.1244~1251 (2008)
- Nguyen MH, "Isolation from coastal sea water and characterization of bacterial strains involved in non-ionic surfactant degradation", Biodegradation, 7, pp.369~375 (1996)
- Naz T, "Biosorption of heavy metals by Pseudomonas species isolated from sugar industry", Toxicol. Ind. Health, 32, pp.1619~1627 (2016)
- Janda JM, "16S rRNA gene sequencing for bacterial identification in the diagnostic laboratory : pluses, perils, and pitfalls", J. Clin. Microbiol, 45, pp.2761~2764 (2007)
- Kim M, "16S rRNA Gene-Based Identification of Bacteria and Archaea using the EzTaxon Server", pp.61~74 (2014)
- Tatusov RL, "The COG database : a tool for genome-scale analysis of protein functions and evolution", Nucleic Acids Res, 28, pp.33~36 (2000)
- Lee I, "OrthoANI : An improved algorithm and software for calculating average nucleotide identity", Int. J. Syst. Evol. Microbiol, 66, pp.1100~1103 (2016)
- Aubin GG, "Propionibacterium namnetense sp. nov., isolated from a human bone infection", Int. J. Syst. Evol. Microbiol., 66, pp.3393~3399 (2016)
- Muynarsk ESM, "Draft genome sequence of pediococcus acidilactici strain LPBC161, isolated from mature coffee cherries during natural fermentation", Microbiol. Resour. Announc, 8, pp.e00332~ (2019)
- Park GS, "Whole genome sequence of lactic acid bacterium Pediococcus acidilactici strain S1", Braz J. Microbiol, 48, pp.395~396 (2017)
- Barreau G, "Draft genome sequence of probiotic strain Pediococcus acidilactici MA18", 5M, 2012, pp.194, 901~
- Park GS, "Draft genome sequence of alcohol-tolerant bacteria Pediococcus acidilactici strain K3", Braz. J. Microbiol, 48, pp.1~2 (2017)
- Doi K, "Draft Genome Sequence of Pediococcus lolii NGRI 0510Q(T)Isolated from Ryegrass Silage", Genome Announce, 1, pp.e00156~ (2013)
- Nihei K, "Identification of oxidation product of arbutin in mushroom tyrosinase assay system", Bioorg. Med. Chem Lett, 13, pp.2409~2412 (2003)
- Palumbo A, "Mechanism of inhibition of melanogenesis by hydroquinone", Biochim. Biophys Acta, 1073, pp.85~90 (1991)
- Wang Y, "Synergistic promotion on tyrosinase inhibition by antioxidants", Molecules, 23, pp.106~ (2018)
- Bilodeau ML, "BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes", Pigment Cell Res, 14, pp.328~336 (2001)
- Tada H, "An improved colorimetric assay for interleukin 2", J. Immunol Method, 93, pp.157~165 (1986)