Understanding the Roles of Host Defense Peptides in Immune Modulation: From Antimicrobial Action to Potential as Adjuvants

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참고문헌 (149)

1. Konno K, "Decoralin, a novel linear cationic alphahelical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus", Peptides, 28, pp.2320~2327 (2007)
2. Yang D, "Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense", Annu. Rev. Immunol, 22, pp.181~215 (2004)
3. Pisano E, "Peptides of human gingival crevicular fluid determined by HPLC-ESI-MS", Eur. J. Oral. Sci, 113, pp.462~468 (2005)
4. Wang G, "APD2: the updated antimicrobial peptide database and its application in peptide design", Nucleic Acids Res, 37, pp.D933~D937 (2009)
5. Wang G, "Improved methods for classification, prediction, and design of antimicrobial peptides", Methods Mol. Biol, 1268, pp.43~66 (2015)
6. Poirel L, "NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman", J. Antimicrob. Chemother, 66, pp.304~306 (2011)
7. Sansom M, "Peptides and lipid bilayers: dynamic interactions", Curr. Opin. Colloid Interface Sci, 3, pp.518~524 (1998)
8. Brogden KA, "Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?", Nat. Rev. Microbiol, 3, pp.238~250 (2005)
9. Yang L, "Barrel-stave model or toroidal model? A case study on melittin pores", Biophys. J, 81, pp.1475~1485 (2001)
10. Yeaman MR, "Mechanisms of antimicrobial peptide action and resistance", Pharmacol. Rev, 55, pp.27~55 (2003)
11. Madani F, "Mechanisms of cellular uptake of cell-penetrating peptides", J. Biophys, 2011, pp.414729~ (2011)
12. Lehrer RI, "Primate defensins", Nat. Rev. Microbiol, 2, pp.727~738 (2004)
13. Currie SM, "The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus", PLoS One, 8, pp.e73659~ (2013)
14. Beaumont PE, "Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo", PLoS One, 9, pp.e99029~ (2014)
15. Mei HF, "Beta-defensin 2 as an adjuvant promotes anti-melanoma immune responses and inhibits the growth of implanted murine melanoma in vivo", PLoS One, 7, pp.e31328~ (2012)
16. Kohlgraf KG, "Defensins as anti-inflammatory compounds and mucosal adjuvants", Fut. Microbiol, 5, pp.99~113 (2010)
17. Diamond G, "The roles of antimicrobial peptides in innate host defense", Curr. Pharm. Des, 15, pp.2377~2392 (2009)
18. Greer A, "Defensins and LL-37: a review of function in the gingival epithelium", Periodontol. 2000, 63, pp.67~79 (2013)
19. Wilde CG, "Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family", J. Biol. Chem, 264, pp.11200~11203 (1989)
20. Gomes Pde S, "Defensins in the oral cavity: distribution and biological role", J. Oral. Pathol. Med, 39, pp.1~9 (2010)
21. Fanali C, "Alpha-defensin levels in whole saliva of totally edentulous subjects", Int. J. Immunopathol. Pharmacol, 21, pp.845~849 (2008)
22. Gorr SU, "Antimicrobial peptides of the oral cavity", Periodontol. 2000, 51, pp.152~180 (2009)
23. Gorr SU, "Antimicrobial peptides and periodontal disease", J. Clin. Periodontol, 38(Suppl 11), pp.126~141 (2011)
24. Allaker RP, "An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora", FEMS Immunol. Med. Microbiol, 23, pp.289~293 (1999)
25. Lehmann J, "Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection", BMC Infect. Dis, 2, pp.20~ (2002)
26. Li X, "New finding of the expression of human beta defensin-4 in healthy gingiva", Hua Xi Kou Qiang Yi Xue Za Zhi, 31, pp.165~168 (2013)
27. Ouhara K, "Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, beta-defensins and LL37, produced by human epithelial cells", J. Antimicrob. Chemother, 55, pp.888~896 (2005)
28. Kościuczuk EM, "Cathelicidins: family of antimicrobial peptides. A review", Mol. Biol. Rep, 39, pp.10957~10970 (2012)
29. Murakami M, "Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva", J. Dent. Res, 81, pp.845~850 (2002)
30. Tecle T, "Defensins and cathelicidins in lung immunity", Innate Immun, 16, pp.151~159 (2010)
31. Bergman P, "The antimicrobial peptide LL-37 inhibits HIV-1replication", Curr. HIV Res, 5, pp.410~415 (2007)
32. Barlow PG, "Antiviral potential of cathelicidins", Future Microbiol, 9, pp.55~73 (2014)
33. Yang D, "Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells", J. Leukoc. Biol, 68, pp.9~14 (2000)
34. Hancock RE, "Antimicrobial and host-defense peptides as new antiinfective therapeutic strategies", Nat. Biotechnol, 24, pp.1551~1557 (2006)
35. Aerts AM, "The mode of antifungal action of plant, insect and human defensins", Cell. Mol. Life Sci, 65, pp.2069~2079 (2008)
36. Klotman ME, "Defensins in innate antiviral immunity", Nat. Rev. Immunol, 6, pp.447~456 (2006)
37. Imamura M, "Multipeptide precursor structure of acaloleptin A isoforms, antibacterial peptides from the Udo longicorn beetle, Acalolepta luxuriosa", Dev. Comp. Immunol, 33, pp.1120~1127 (2009)
38. Yoe SM, "Characterization and cDNA cloning of hinnavin II, a cecropin family antibacterial peptide from the cabbage butterfly, Artogeia rapae", Comp. Biochem. Physiol. B Biochem. Mol. Biol, 144, pp.199~205 (2006)
39. Giesemann T, "Human alpha-defensins inhibit Clostridium difficile toxin B", Gastroenterology, 134, pp.2049~2058 (2008)
40. Schroder JM, "Epithelial antimicrobial peptides: innate local host response elements", Cell. Mol. Life Sci, 56, pp.32~46 (1999)
41. Hoover DM, "Antimicrobial characterization of human beta-defensin 3 derivatives", Antimicrob. Agents Chemother, 47, pp.2804~2809 (2003)
42. Wu Z, "Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3", Proc. Natl. Acad. Sci. USA, 100, pp.8880~8885 (2003)
43. Maisetta G, "In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains", Antimicrob. Agents Chemother, 50, pp.806~809 (2006)
44. Zhu C, "Human beta-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation", J. Surg. Res, 183, pp.204~213 (2013)
45. Huang L, "Production of bioactive human beta-defensin 5 and 6 in E. coli by soluble fusion expression", Protein Expression Purif, 61, pp.168~174 (2008)
46. Corrales-Garcia L, "Bacterial expression and antibiotic activities of recombinant variants of human beta-defensins on pathogenic bacteria and M. tuberculosis", Protein Expression Purif, 89, pp.33~43 (2013)
47. Kim JY, "Human fungal pathogens: why should we learn?", J. Microbiol, 54, pp.145~148 (2016)
48. Revie NM, "Antifungal drug resistance: evolution, mechanisms and impact", Curr. Opin. Microbiol, 45, pp.70~76 (2018)
49. Vriens K, "Antifungal plant defensins: mechanisms of action and production", Molecules, 19, pp.12280~12303 (2014)
50. Parisi K, "The evolution, function and mechanisms of action for plant defensins", Semin. Cell Dev. Biol, 88, pp.107~118 (2019)
51. Puri S, "How does it kill?: understanding the candidacidal mechanism of salivary histatin 5", Eukaryot. Cell, 13, pp.958~964 (2014)
52. Menzel LP, "Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism", Sci. Rep, 7, pp.4353~ (2017)
53. Baek JH, "Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera:Eumenidae)", Toxicon, 55, pp.711~718 (2010)
54. Dang XL, "Bactrocerin-1: a novel inducible antimicrobial peptide from pupae of oriental fruit fly Bactrocera dorsalis Hendel", Arch. Insect. Biochem. Physiol, 71, pp.117~129 (2009)
55. Daher KA, "Direct inactivation of viruses by human granulocyte defensins", J. Virol, 60, pp.1068~1074 (1986)
56. Salvatore M, "alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s)", J. Infect. Dis, 196, pp.835~843 (2007)
57. Carballar-Lejarazu R, "Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens", Cell. Mol. Life Sci, 65, pp.3081~3092 (2008)
58. Ryan LK, "Detection of HBD1 peptide in peripheral blood mononuclear cell subpopulations by intracellular flow cytometry", Peptides, 24, pp.1785~1794 (2003)
59. Ryan LK, "Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity", J. Leukoc. Biol, 90, pp.343~356 (2011)
60. Funderburg N, "Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2", Proc. Natl. Acad. Sci. USA, 104, pp.18631~18635 (2007)
61. Cole AM, "Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1", Proc. Natl. Acad. Sci. USA, 99, pp.1813~1818 (2002)
62. Wilson SS, "Antiviral mechanisms of human defensins", J. Mol. Biol, 425, pp.4965~4980 (2013)
63. Chertov O, "Identification of defensin-1, defensin-2, and CAP37", azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils, 1996, pp.271, 2935~2940
64. Nagaoka I, "Cathelicidin family of antibacterial peptides CAP18and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14+ cells", J. Immunol, 167, pp.3329~3338 (2001)
65. Rosenfeld Y, "Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action", J. Biol. Chem, 281, pp.1636~1643 (2006)
66. Mookherjee N, "Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37", J. Immunol, 176, pp.2455~2464 (2006)
67. Merkle M, "LL37 inhibits the inflammatory endothelial response induced by viral or endogenous DNA", J. Autoimmun, 65, pp.19~29 (2015)
68. van Dijk A, "Immunomodulatory and anti-inflammatory activities of chicken cathelicidin-2 derived peptides", PLoS One, 11, pp.e0147919~ (2016)
69. Mookherjee N, "Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide", J. Leukoc. Biol, 80, pp.1563~1574 (2006)
70. Coorens M, "Cathelicidins inhibit Escherichia coliinduced TLR2 and TLR4 activation in a viability-dependent manner", J. Immunol, 199, pp.1418~1428 (2017)
71. Choi KY, "Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation", Immunology, 143, pp.68~80 (2014)
72. Li N, "Alarmin function of cathelicidin antimicrobial peptide LL37 through IL-36gamma induction in human epidermal keratinocytes", J. Immunol, 193, pp.5140~5148 (2014)
73. Semple F, "Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo", Eur. J. Immunol, 40, pp.1073~1078 (2010)
74. Semple F, "Human β-defensin 3 affects the activity of proinflammatory pathways associated with MyD88 and TRIF", Eur. J. Immunol, 41, pp.3291~3300 (2011)
75. Funderburg NT, "The Toll-like receptor 1", 2 agonists Pam3CSK4and human beta-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes, 2011, pp.134, 151~160
76. Severino P, "Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture", J. Mol. Med, 95, pp.995~1003 (2017)
77. Wehkamp J, "Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn’s disease", J. Leukoc. Biol, 77, pp.460~465 (2005)
78. Wuerth KC, "Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection", PLoS One, 12, pp.e0187565~ (2017)
79. Hou M, "Antimicrobial peptide LL-37 and IDR-1 ameliorate MRSA pneumonia in vivo", Cell Physiol. Biochem, 32, pp.614~623 (2013)
80. Coorens M, "Killing of P. aeruginosa by chicken cathelicidin-2 is immunogenically silent, preventing lung inflammation in vivo", Infect. Immun, 85, pp.e00546-17~ (2017)
81. Chow LN, "Human cathelicidin LL-37-derived peptide IG-19confers protection in a murine model of collagen-induced arthritis", Mol. Immunol, 57, pp.86~92 (2014)
82. Tjabringa GS, "Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors", Int. Arch. Allergy Immunol, 140, pp.103~112 (2006)
83. Hemshekhar M, "Host defense peptide LL-37-mediated chemoattractant properties, but not antiinflammatory cytokine IL-1RA production, is selectively controlled by Cdc42 Rho GTPase via G protein-coupled receptors and JNK mitogen-activated protein kinase", Front. Immunol, 9, pp.1871~ (2018)
84. Hancock RE, "The immunology of host defence peptides: beyond antimicrobial activity", Nat. Rev. Immunol, 16, pp.321~334 (2016)
85. Nijnik A, "Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment", J. Immunol, 184, pp.2539~2550 (2010)
86. Madera L, "Synthetic immunomodulatory peptide IDR-1002 enhances monocyte migration and adhesion on fibronectin", J. Innate Immun, 4, pp.553~568 (2012)
87. Scott MG, "The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses", J. Immunol, 169, pp.3883~3891 (2002)
88. Choi KY, "Multiple immunemodulatory functions of cathelicidin host defense peptides", Front. Immunol, 3, pp.149~ (2012)
89. Holly MK, "Defensins in viral infection and pathogenesis", Annu. Rev. Virol, 4, pp.369~391 (2017)
90. Agier J, "Cathelicidin impact on inflammatory cells", Cent. Eur. J. Immunol, 40, pp.225~235 (2015)
91. Suarez-Carmona M, "Defensins: “simple” antimicrobial peptides or broad-spectrum molecules?", Cytokine Growth Factor Rev, 26, pp.361~370 (2015)
92. Mookherjee N, "Intracellular receptor for human host defense peptide LL-37 in monocytes", J. Immunol, 183, pp.2688~2696 (2009)
93. Yu HB, "Sequestosome-1", p62 is the key intracellular target of innate defense regulator peptide, 2009, pp.284, 36007~36011
94. Tewary P, "Beta-defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-alpha production by human plasmacytoid dendritic cells, and promote inflammation", J. Immunol, 191, pp.865~874 (2013)
95. Kim J, "Human β-defensin 2 is involved in CCR2-mediated Nod2 signal transduction, leading to activation of the innate immune response in macrophages", Immunobiology, 224, pp.502~510 (2019)
96. Biragyn A, "Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2", Science, 298, pp.1025~1029 (2002)
97. Yang D, "Betadefensins: linking innate and adaptive immunity through dendritic and T cell CCR6", Science, 286, pp.525~528 (1999)
98. Kurosaka K, "Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1", mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant, 2005, pp.174, 6257~6265
99. Kim J, "Conjugation of human beta-defensin 2 to spike protein receptor-binding domain induces antigen-specific protective immunity against middle east respiratory syndrome coronavirus infection in human dipeptidyl peptidase 4 transgenic mice", Vaccines, 8, pp.635~ (2020)
100. Maroti G, "Natural roles of antimicrobial peptides in microbes, plants and animals", Res. Microbiol, 62, pp.363~374 (2011)
101. Park CB, "Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II", Proc. Natl. Acad. Sci. USA, 97, pp.8245~8250 (2000)
102. Subbalakshmi C, "Mechanism of antimicrobial action of indolicidin", FEMS Microbiol. Lett, 160, pp.91~96 (1998)
103. Lai Y, "AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense", Trends Immunol, 30, pp.131~141 (2009)
104. Yeung ATY, "Multifunctional cationic host defence peptides and their clinical applications", Cell. Mol. Life Sci, 68, pp.2161~2176 (2011)
105. Nicholls EF, "Immunomodulators as adjuvants for vaccines and antimicrobial therapy", Ann. NY Acad. Sci, 1213, pp.46~61 (2010)
106. Brown KL, "Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses", J. Immunol, 186, pp.5497~5505 (2011)
107. van der Does AM, "LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature", J. Immunol, 185, pp.1442~1449 (2010)
108. An LL, "LL-37 enhances adaptive antitumor immune response in a murine model when genetically fused with M-CSFR (J6-1) DNA vaccine", Leuk. Res, 29, pp.535~543 (2005)
109. Davidson DJ, "The cationic antimicrobial peptide LL-37modulates dendritic cell differentiation and dendritic cell-induced T cell polarization", J. Immunol, 172, pp.1146~1156 (2004)
110. van der Does AM, "Antimicrobial host defence peptides: immunomodulatory functions and translational prospects", Adv. Exp. Med. Biol, 1117, pp.149~171 (2019)
111. Barlow PG, "Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37", PLoS One, 6, pp.e25333~ (2011)
112. Sano H, "Lactoferrin and surfactant protein A exhibit distinct binding specificity to F protein and di_erently modulate respiratory syncytial virus infection", Eur. J. Immunol, 33, pp.2894~2902 (2003)
113. Gronberg A, "Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical trial", Wound Repair Regen, 22, pp.613~621 (2014)
114. Sørensen OE, "Wound healing and expression of antimicrobial peptides", polypeptides in human keratinocytes, a consequence of common growth factors, 2003, pp.170, 5583~5589
115. Li D, "Gene therapy with beta-defensin 2 induces antitumor immunity and enhances local antitumor effects", Hum. Gene Ther, 25, pp.63~72 (2014)
116. Otvos, L, "Host defense peptides and cancer; perspectives on research design and outcomes", Protein Pept. Lett, 24, pp.879~886 (2017)
117. Adams LG, "Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: linking systems biology with vaccine development", Vaccine, 29, pp.7197~7206 (2011)
118. Rivas-Santiago B, "Expression of beta defensin 2 in experimental pulmonary tuberculosis: tentative approach for vaccine development", Arch. Med. Res, 43, pp.324~328 (2012)
119. Rohrl J, "Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2", J. Immunol, 184, pp.6688~6694 (2010)
120. 주성미, "Extracellular HIV-1 Tat Induces Human Beta-Defensin-2 Production Via NF-kappaB", AP-1 Dependent Pathways in Human B Cells, 2012, pp.33(4), 335~341[DOI]
121. Allaker RP, "Host defence peptides-a bridge between the innate and adaptive immune responses", Trans. R. Soc. Trop. Med. Hyg, 102, pp.3~4 (2008)
122. Nierkens S, "Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?", Trends. Immunol, 34, pp.361~370 (2013)
123. Alu A, "Intranasal COVID-19 vaccines: from bench to bed", EBioMedicine, 76, pp.103841~ (2022)
124. Kim Ju, "Application of Antimicrobial Peptide LL-37 as an Adjuvant for Middle East Respiratory Syndrome-Coronavirus Antigen Induces an Efficient Protective Immune Response Against Viral Infection After Intranasal Immunization", Immune Network, 22(5), pp.1~16 (2022), 대한면역학회[DOI]
125. Coorens M, "Importance of endosomal cathelicidin degradation to enhance DNA-induced chicken macrophage activation", J. Immunol, 195, pp.3970~3977 (2015)
126. Sandgren S, "The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis", J. Biol. Chem, 279, pp.17951~17956 (2004)
127. Jadhav NJ, "Effect of full-length and truncated variants of LL-37 on dengue virus infection and immunomodulatory effects of LL-37 in dengue virus infected U937-DC-SIGN cells", Int. J. Pept. Res. Ther, 26, pp.547~555 (2019)
128. Matsumura T, "Antimicrobial peptide LL-37 attenuates infection of hepatitis C virus", Hepatol. Res, 46, pp.924~932 (2016)
129. Honda JR, "Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy", J. Med. Microbiol, 63, pp.997~1003 (2014)
130. Schogler A, "Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37", Eur. Respir. J, 47, pp.520~530 (2016)
131. Lee CJ, "Cathelicidin LL-37 and HSV-1 corneal infection:peptide versus gene therapy", Transl. Vis. Sci. Technol, 3, pp.4~ (2014)
132. Tripathi S, "LL-37 modulates human neutrophil responses to influenza A virus", J. Leukoc. Biol, 96, pp.931~938 (2014)
133. Harcourt JL, "Human cathelicidin, LL-37, inhibits respiratory syncytial virus infection in polarized airway epithelial cells", BMC Res. Notes, 9, pp.11~ (2016)
134. Dean RE, "A carpet-based mechanism for direct antimicrobial peptide activity against vaccinia virus membranes", Peptides, 31, pp.1966~1972 (2010)
135. Ahmed A, "Human cathelicidin peptide LL-37 as a therapeutic antiviral targeting Venezuelan equine encephalitis virus infections", Antiviral Res, 164, pp.61~69 (2019)
136. He M, "Cathelicidin-derived antimicrobial peptides inhibit Zika virus through direct inactivation and interferon pathway", Front. Immunol, 9, pp.722~ (2018)
137. Chang TL, "Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity", J. Clin. Investig, 115, pp.765~773 (2005)
138. Smith JG, "Mechanism of adenovirus neutralization by Human alpha-defensins", Cell Host Microbe, 3, pp.11~19 (2008)
139. Hazrati E, "Human alphaand beta-defensins block multiple steps in herpes simplex virus infection", J. Immunol, 177, pp.8658~8666 (2006)
140. Hsieh IN, "The role of antimicrobial peptides in influenza virus infection and their potential as antiviral and immunomodulatory therapy", Pharmaceuticals, 9, pp.53~ (2016)
141. Buck CB, "Human alpha-defensins block papillomavirus infection", Proc. Natl. Acad. Sci. USA, 103, pp.1516~1521 (2006)
142. Wu Z, "Human neutrophil alpha-defensin 4 inhibits HIV-1infection in vitro", FEBS Lett, 579, pp.162~166 (2005)
143. Furci L, "Inhibition of HIV-1 infection by human alpha-defensin-5, a natural antimicrobial peptide expressed in the genital and intestinal mucosae", PLoS One, 7, pp.e45208~ (2012)
144. Wiens ME, "Alpha-defensin HD5 inhibits human papillomavirus 16 infection via capsid stabilization and redirection to the lysosome", mBio, 8, pp.e02304~ (2017)
145. Galván Morales MA, "Effect of human beta defensin-2 in epithelial cell lines infected with respiratory viruses", J. Bioanal. Biomed, 7, pp.136~143 (2015)
146. Quinones-Mateu ME, "Human epithelial beta-defensins 2and 3 inhibit HIV-1 replication", AIDS, 17, pp.F39~F48 (2003)
147. Kota S, "Role of human beta-defensin-2 during tumor necrosis factoralpha", NF-kappaB-mediated innate antiviral response against human respiratory syncytial virus, 2008, pp.283, 22417~22429
148. Arnason JW, "Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD", PLoS One, 12, pp.e0175963~ (2017)
149. Howell MD, "Antiviral activity of human beta-defensin 3 against vaccinia virus", J. Allergy Clin. Immunol, 119, pp.1022~1025 (2007)

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