본문 바로가기
KERD
논문KCI 등재

Recent Advances of Vaccine Adjuvants for Infectious Diseases

2

조회

0

다운로드

3

인용

0

참고문헌

키워드

초록

Vaccines are the most effective and cost-efficient method for preventing diseases caused by infectious pathogens. Despite the great success of vaccines, development of safe and strong vaccines is still required for emerging new pathogens, re-emerging old pathogens, and in order to improve the inadequate protection conferred by existing vaccines. One of the most important strategies for the development of effective new vaccines is the selection and usage of a suitable adjuvant. Immunologic adjuvants are essential for enhancing vaccine potency by improvement of the humoral and/or cell-mediated immune response to vaccine antigens. Thus, formulation of vaccines with appropriate adjuvants is an attractive approach towards eliciting protective and long-lasting immunity in humans. However, only a limited number of adjuvants is licensed for human vaccines due to concerns about safety and toxicity. We summarize current knowledge about the potential benefits of adjuvants, the characteristics of adjuvants and the mechanisms of adjuvants in human vaccines. Adjuvants have diverse modes of action and should be selected for use on the basis of the type of immune response that is desired for a particular vaccine. Better understanding of current adjuvants will help exploring new adjuvant formulations and facilitate rational design of vaccines against infectious diseases.

Abstract

Vaccines are the most effective and cost-efficient method for preventing diseases caused by infectious pathogens. Despite the great success of vaccines, development of safe and strong vaccines is still required for emerging new pathogens, re-emerging old pathogens, and in order to improve the inadequate protection conferred by existing vaccines. One of the most important strategies for the development of effective new vaccines is the selection and usage of a suitable adjuvant. Immunologic adjuvants are essential for enhancing vaccine potency by improvement of the humoral and/or cell-mediated immune response to vaccine antigens. Thus, formulation of vaccines with appropriate adjuvants is an attractive approach towards eliciting protective and long-lasting immunity in humans. However, only a limited number of adjuvants is licensed for human vaccines due to concerns about safety and toxicity. We summarize current knowledge about the potential benefits of adjuvants, the characteristics of adjuvants and the mechanisms of adjuvants in human vaccines. Adjuvants have diverse modes of action and should be selected for use on the basis of the type of immune response that is desired for a particular vaccine. Better understanding of current adjuvants will help exploring new adjuvant formulations and facilitate rational design of vaccines against infectious diseases.

참고문헌 (51)

  1. Fauci, A. S., "Infectious diseases: considerations for the 21st century", Clin. Infect. Dis, 32, pp.675~685 (2001)
  2. Leroux-Roels, G., "Unmet needs in modern vaccinology:adjuvants to improve the immune response", Vaccine, 28(Suppl 3), pp.C25~C36 (2010)
  3. Chan, E. H., "Global capacity for emerging infectious disease detection", Proc. Natl. Acad. Sci. U. S. A, 107, pp.21701~21706 (2010)
  4. WHO Ebola Response Team, "Ebola virus disease in West Africa--the first 9 months of the epidemic and forward projections", N. Engl. J. Med, 371, pp.1481~1495 (2014)
  5. Riese, P., "Vaccine adjuvants: key tools for innovative vaccine design", Curr. Top. Med. Chem, 13, pp.2562~2580 (2013)
  6. Baxter D., "Active and passive immunity, vaccine types, excipients and licensing", Occup. Med. (Lond), 57, pp.552~556 (2007)
  7. Reed, S. G., "Key roles of adjuvants in modern vaccines", Nat. Med, 19, pp.1597~1608 (2013)
  8. Glenny, A. T., "Immunological notes. XVII–XXIV", J. Pathol. Bacteriol, 29, pp.31~40 (1926)
  9. Brewer, J. M., "(How) do aluminium adjuvants work?", Immunol. Lett, 102, pp.10~15 (2006)
  10. Lindblad, E. B, "Aluminium adjuvants--in retrospect and prospect", Vaccine, 22, pp.3658~3668 (2004)
  11. Glenny, A. T., "The antigenic effect of intravenous injection of diphtheria toxin", J. Pathol. Bacteriol, 28, pp.273~278 (1925)
  12. Hutchison, S., "Antigen depot is not required for alum adjuvanticity", FASEB J, 26, pp.1272~1279 (2012)
  13. Awate, S., "Mechanisms of action of adjuvants", Front. Immunol, 4, pp.114~ (2013)
  14. Marrack, P., "Towards an understanding of the adjuvant action of aluminium", Nat. Rev. Immunol, 9, pp.287~293 (2009)
  15. Reed, S. G., "New horizons in adjuvants for vaccine development", Trends Immunol, 30, pp.23~32 (2009)
  16. Gupta, R. K., "Aluminum compounds as vaccine adjuvants", Adv. Drug Deliv. Rev, 32, pp.155~172 (1998)
  17. O'Hagan, D. T., "The mechanism of action of MF59 - an innately attractive adjuvant formulation", Vaccine, 30, pp.4341~4348 (2012)
  18. Podda, A., "The adjuvanted influenza vaccines with novel adjuvants : experience with the MF59-adjuvanted vaccine", Vaccine, 19, pp.2673~2680 (2001)
  19. Gasparini, R., "Impact of prior or concomitant seasonal influenza vaccination on MF59-adjuvanted H1N1v vaccine (Focetria) in adult and elderly subjects", Int. J. Clin. Pract, 64, pp.432~438 (2010)
  20. Calabro, S., "Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes", Vaccine, 29, pp.1812~1823 (2011)
  21. O'Hagan, D. T., "The history of MF59(®)adjuvant : a phoenix that arose from the ashes. Expert Rev", Vaccines, 12, pp.13~30 (2013)
  22. Morel, S., "Adjuvant System AS03 containing alpha-tocopherol modulates innate immune response and leads to improved adaptive immunity", Vaccine, 29, pp.2461~2473 (2011)
  23. Brito, L. A., "Designing and building the next generation of improved vaccine adjuvants", J. Control Release, 190, pp.563~579 (2014)
  24. Almeida, J. D., "Formation of virosomes from influenza subunits and liposomes", Lancet, 2, pp.899~901 (1975)
  25. Moser, C., "Influenza virosomes as a combined vaccine carrier and adjuvant system for prophylactic and therapeutic immunizations", Expert Rev. Vaccines, 6, pp.711~721 (2007)
  26. Cusi, M. G., "Applications of influenza virosomes as a delivery system", Hum. Vaccin, 2, pp.1~7 (2006)
  27. Medzhitov, R., "Toll-like receptors and innate immunity", Nat. Rev. Immunol, 1, pp.135~145 (2001)
  28. Coffman, R. L., "Vaccine adjuvants:putting innate immunity to work", Immunity, 33, pp.492~503 (2010)
  29. Gustafson, G. L., "Bacterial cell wall products as adjuvants: early interferon gamma as a marker for adjuvants that enhance protective immunity", Res. Immunol, 143, pp.483~488 (1992)
  30. Garcon, N., "GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectives", Expert Rev. Vaccines, 6, pp.723~739 (2007)
  31. Descamps, D., "Safety of human papillomavirus (HPV)-16", 18 AS04-adjuvanted vaccine for cervical cancer prevention: a pooled analysis of 11 clinical trials, 2009, pp.5, 332~340
  32. Beran, J., "Safety and immunogenicity of a new hepatitis B vaccine for the protection of patients with renal insufficiency including pre-haemodialysis and haemodialysis patients", Expert Opin. Biol. Ther, 8, pp.235~247 (2008)
  33. Didierlaurent, A. M., "AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity", J. Immunol, 183, pp.6186~6197 (2009)
  34. Krieg, A. M., "Therapeutic potential of Toll-like receptor 9 activation", Nat. Rev. Drug Discov, 5, pp.471~484 (2006)
  35. Eng, N. F., "The potential of 1018 ISS adjuvant in hepatitis B vaccines:HEPLISAV review", Hum. Vaccin. Immunother, 9, pp.1661~1672 (2013)
  36. Hasegawa, H., "Development of mucosal adjuvants for intranasal vaccine for H5N1 influenza viruses", Ther. Clin. Risk Manag, 5, pp.125~132 (2009)
  37. Duthie, M. S., "Use of defined TLR ligands as adjuvants within human vaccines", Immunol. Rev, 239, pp.178~196 (2011)
  38. Taylor, D. N., "Development of VAX128, a recombinant hemagglutinin (HA) influenza-flagellin fusion vaccine with improved safety and immune response", Vaccine, 30, pp.5761~5769 (2012)
  39. Turley, C. B., "Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine(STF2. 4xM2e)in healthy adults", Vaccine, 29, pp.5145~5152 (2011)
  40. Morein, B., "Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses", Nature, 308, pp.457~460 (1984)
  41. Garcia, A., "An overview of adjuvant formulations and delivery systems", APMIS, 122, pp.257~267 (2014)
  42. Lovgren, B. K., "ISCOM technology-based Matrix MTM adjuvant : success in future vaccines relies on formulation. Expert Rev", Vaccines, 10, pp.401~403 (2011)
  43. Cummings, J. F., "Recombinant Liver Stage Antigen-1(LSA-1)formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma", IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection, 2010, pp.28, 5135~5144
  44. Oleszycka, E., "Immunomodulatory properties of the vaccine adjuvant alum", Curr. Opin. Immunol, 28, pp.1~5 (2014)
  45. De, G. E., "Alum adjuvanticity:unraveling a century old mystery", Eur. J. Immunol, 38, pp.2068~2071 (2008)
  46. O'Hagan, D. T., "Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles", Mol. Med. Today, 3, pp.69~75 (1997)
  47. Garcon, N., "Development and evaluation of AS03, an Adjuvant System containing alpha-tocopherol and squalene in an oil-in-water emulsion", Expert Rev. Vaccines, 11, pp.349~366 (2012)
  48. Atmar, R. L., "Adjuvants for pandemic influenza vaccines", Curr. Top. Microbiol. Immunol, 333, pp.323~344 (2009)
  49. Schwendener, R. A., "Liposomes as vaccine delivery systems:a review of the recent advances", Ther. Adv. Vaccines, 2, pp.159~182 (2014)
  50. Moser, C., "Influenza virosomes as vaccine adjuvant and carrier system", Expert Rev. Vaccines, 12, pp.779~791 (2013)
  51. Garcon, N., "Role of AS04 in human papillomavirus vaccine: mode of action and clinical profile", Expert Opin. Biol. Ther, 11, pp.667~677 (2011)

관련 논문AI추천

이 간행물의 다른 논문 (6건)