폐경여성에서 무증상 갑상선 기능 저하증과 심혈관계 위험인자와의 관련성
The Association between Subclinical Hypothyroidism and Cardiovascular Risk Factors in Post-menopausal Women
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초록
연구목적: 폐경여성에서의 무증상 갑상선 기능 저하증의 유병률과 심혈관계 질환과의 관련성을 분석하여 무증상 갑상선 기능 저하증에 관한 연구에 기여하고자 하였다. 연구재료 및 방법: 2006년 9월부터 2010년 8월까지 종합병원 건강검진센터를 방문한 폐경여성 중 무증상 갑상선 기능 저하증인 50명과 갑상선 기능이 정상인 663명을 대상으로 심혈관계 질환 위험인자 중 혈압, 혈중 지질, 체질량지수, 공복혈당의 관련성을 분석하였다. 자료는 독립표본 t 검정법으로 분석하였다. 결과: 폐경여성의 무증상 갑상선 기능 저하증의 유병률은 6.7%이었다. 무증상 갑상선 기능 저하증군과 정상군에서 혈압, 체질량지수, 공복혈당, 총 콜레스테롤, 고밀도 콜레스테롤, 저밀도 콜레스테롤 수치는 유의한 차이를 보이지 않았으나(P > 0.05), 중성지방만이 무증상 갑상선 기능 저하증 환자에서 유의하게 높게 관찰되었다(P = 0.003). 결론: 폐경여성에서 무증상 갑상선 기능 저하증이 심혈관계 질환 위험인자 중 중성지방의 상승과 관련성이 있으므로 해당 환자군에서 철저한 지질 관리 및 심혈관계 질환의 주의를 해야 할 것이다.
Abstract
Objectives: The relationship between subclinical hypothyroidism and cardiovascular disease has not yet been clearly defined. This study will investigate whether or not there is a difference in the prevalence of subclinical hypothyroidism in menopausal women with respect to cardiovascular risk factors, and will furthermore analyze the relationship between cardiovascular diseases and subclinical hypothyroidism, in order to establish a foundation for subclinical hypothyroidism research. Methods: The study subjects consisted of 713 post-menopausal women, who visited the hospital for a health check-up in 2006-2010. They were divided into a subclinical hypothyroidism group and a normal group. This study analyzed the difference in blood pressure, serum lipid, body mass index (BMI) and blood glucose level between the two groups. The data was analyzed using a two-sample t-test. Results: The prevalence of subclinical hypothyroidism for menopausal women was 6.7%. The results showed no significant differences between the normal and subclinical hypothyroidism patient groups, in regards to blood pressure, BMI, and blood glucose levels (P > 0.05). However the triglyceride of serum lipid was significantly higher in the subclinical hypothyroidism group (P = 0.003). Conclusion: It has been confirmed that the triglyceride of the subclinical hypothyroidism group was higher than that of the normal group, and so serum lipid maintenance and caution towards cardiovascular disease is necessary for the subclinical hypothyroidism group.
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