Alteration of Lipid Profiles in Patients with Subclinical Hypothyroidism
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Objectives: Overt hypothyroidism has been associated with abnormalities of lipid metabolism; however conflicting resultsregarding the degree of lipid changes in subclinical hypothyroidism (SCH) have been reported. The aim of this study wasto assess differences in lipid profile parameters between people with and without SCH in Korean population. Methods: Serum lipid parameters of 37 patients with SCH and 44 euthyroid control subjects were evaluated in a retrospectivecross-sectional study. Results: The mean serum triglycerides (TG) level was significantly higher in patients with SCH than in controls (p<0.05). The mean serum high-density lipoprotein cholesterol (HDL-C) level was significantly lower in patients with SCH than incontrols (p<0.05). When adjusted by age, the odds ratio for the association of HDL-C with SCH was significant at 0.893(95% confidence interval 0.809-0.986) compared with that of the euthyroid controls. No association with SCH was foundwith total cholesterol level, low-density lipoprotein cholesterol level or serum thyroid-stimulating hormone level. In addition,the lipid profile did not differ significantly between premenopausal and postmenopausal women. Conclusions: We found variations of lipid profiles in patients with SCH, characterized by a significantly lower HDL-C level. (J Lipid Atheroscler 2017 December;6(2):84-88)
Abstract
Objectives: Overt hypothyroidism has been associated with abnormalities of lipid metabolism; however conflicting resultsregarding the degree of lipid changes in subclinical hypothyroidism (SCH) have been reported. The aim of this study wasto assess differences in lipid profile parameters between people with and without SCH in Korean population. Methods: Serum lipid parameters of 37 patients with SCH and 44 euthyroid control subjects were evaluated in a retrospectivecross-sectional study. Results: The mean serum triglycerides (TG) level was significantly higher in patients with SCH than in controls (p<0.05). The mean serum high-density lipoprotein cholesterol (HDL-C) level was significantly lower in patients with SCH than incontrols (p<0.05). When adjusted by age, the odds ratio for the association of HDL-C with SCH was significant at 0.893(95% confidence interval 0.809-0.986) compared with that of the euthyroid controls. No association with SCH was foundwith total cholesterol level, low-density lipoprotein cholesterol level or serum thyroid-stimulating hormone level. In addition,the lipid profile did not differ significantly between premenopausal and postmenopausal women. Conclusions: We found variations of lipid profiles in patients with SCH, characterized by a significantly lower HDL-C level. (J Lipid Atheroscler 2017 December;6(2):84-88)
참고문헌 (11)
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