한국 성인에서 무증상 갑상선기능저하증과 대사증후군 및 비타민 D와의 연관성: 2013-2015년 국민건강영양조사 자료를 이용하여
Relationships between Subclinical Hypothyroidism and Metabolic Syndrome and Vitamin D Status in Korean Adults: Korea National Health and Nutrition Examination Survey 2013-2015
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연구배경: 지금까지 현성 갑상선기능저하증에서 대사증후군의 유병률이 높다는 것은 여러 연구를 통해 알려져 있다. 하지만 무증상 갑상선기능저하증과 대사증후군의 관계를 본 결과는 연구마다 결과가 상이하다. 따라서 본 연구에서는 우리나라 성인에서 무증상 갑상선기능저하증과 대사증후군 그리고 비타민 D의 관계를 알아보고자 하였다. 방법: 제6기 국민건강영양조사의 자료를 이용하여, 갑상선검사에 참여한 19세 이상 수검자 중 정상 갑상선기능군과무증상 갑상선기능저하증군을 대상으로 갑상선호르몬, 비타민 D와 대사증후군과의 연관성을 분석하기 위해 카이-제곱 검정, 일반화 선형모델, 로지스틱 회귀분석을 실행하였다. 결과: 정상 갑상선기능군에서 무증상 갑상선기능저하증군에서보다 대사증후군 구성요소 중 수축기 혈압과 공복 혈당이 높았고, 비타민 D는 무증상 갑상선기능저하증군에서더 낮게 나타났다. 하지만 관련 변수들을 보정한 뒤에는 대사증후군, 비타민 D와 무증상 갑상선기능저하증는 통계적으로 유의한 연관관계를 보이지 않았다. 결론: 한국 성인에서 무증상 갑상선기능저하증과 대사증후군, 비타민 D는 연관성이 없는 것으로 나타났다.
Abstract
Background: Many studies have established the association between overt hypothyroidism and metabolic syndrome (MS). However, the relationship between subclinical hypothyroidism (SCH) and MS varies from study to study. This study aimed to investigate associations between SCH and components of MS and vitamin D status in Korean adults. Methods: Using data from the 6th Korea National Health and Nutrition Examination Survey (2013-2015), chi-squared tests and t-tests were used to explore relationships between thyroid hormones and components of MS and vitamin D status. Multiple regression analysis was undertaken to assess relationships between SCH and components of MS and vitamin D. Results: Systolic blood pressure and fasting glucose were significantly higher in the euthyroid (EUT) group than in the SCH group, and vitamin D status was significantly lower in the SCH group than EUT. However, in multiple regression analysis, SCH presented no significant association with components of MS or vitamin D status even after adjusting for age, sex, drinking, and smoking. Conclusions: In Korean adults, there is no significant association between SCH and MS or vitamin D.
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