Superficial Angiomyxoma of the Vulva in a Postmenopausal Woman: A Case Report and Review of Literature
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Superficial angiomyxomas (SAMs) are rare benign cutaneous tumors that involve the subcutaneous layer. They are commonly located in the trunk, lower limbs and head or neck of women of reproductive age. SAMs in the vulva of postmenopausal women are especially rare case. Herein, we report a vulvar SAM in a postmenopausal 60-year-old woman. The patient presented with a palpable cutaneous mass in the right labium majora that had appeared 3 months earlier. The mass was slow growing and approximately 5 cm in size and resembled a soft tissue malignancy. It appeared as a well-defined multilocular cystic mass in magnetic resonance images. The preoperative diagnosis was a benign cystic lesion such as an epidermoid cyst. Grossly, the completely excised mass was 6 x 5 cm in size and well circumscribed with a multilocular outer surface, a yellowish-gray gelatinous cut surface, and a smooth rubbery inner surface. Histologic review revealed that the mass contained small to moderate amount of cellular angiomyxoid nodules and bland-looking spindle-shaped to ovoid cells without atypia. Neutrophil infiltration, which is a diagnostic feature of SAMs, was observed. Immunohistochemistry showed expression of CD34, but not of estrogen receptors, progesterone receptors, or desmin in the SAM. The patient has been followed up for 12 months without recurrence. (J Menopausal Med 2016;22:180-183)
Abstract
Superficial angiomyxomas (SAMs) are rare benign cutaneous tumors that involve the subcutaneous layer. They are commonly located in the trunk, lower limbs and head or neck of women of reproductive age. SAMs in the vulva of postmenopausal women are especially rare case. Herein, we report a vulvar SAM in a postmenopausal 60-year-old woman. The patient presented with a palpable cutaneous mass in the right labium majora that had appeared 3 months earlier. The mass was slow growing and approximately 5 cm in size and resembled a soft tissue malignancy. It appeared as a well-defined multilocular cystic mass in magnetic resonance images. The preoperative diagnosis was a benign cystic lesion such as an epidermoid cyst. Grossly, the completely excised mass was 6 x 5 cm in size and well circumscribed with a multilocular outer surface, a yellowish-gray gelatinous cut surface, and a smooth rubbery inner surface. Histologic review revealed that the mass contained small to moderate amount of cellular angiomyxoid nodules and bland-looking spindle-shaped to ovoid cells without atypia. Neutrophil infiltration, which is a diagnostic feature of SAMs, was observed. Immunohistochemistry showed expression of CD34, but not of estrogen receptors, progesterone receptors, or desmin in the SAM. The patient has been followed up for 12 months without recurrence. (J Menopausal Med 2016;22:180-183)
참고문헌 (12)
- Carney JA, "Cutaneous myxomas. A major component of the complex of myxomas, spotty pigmentation, and endocrine overactivity", Arch Dermatol, 122, pp.790~798 (1986)
- Allen PW, "Myxoma is not a single entity: a review of the concept of myxoma", Ann Diagn Pathol, 4, pp.99~123 (2000)
- Allen PW, "Superficial angiomyxomas with and without epithelial components. Report of 30 tumors in 28 patients", Am J Surg Pathol, 12, pp.519~530 (1988)
- Fetsch JF, "Superficial angiomyxoma (cutaneous myxoma): a clinicopathologic study of 17 cases arising in the genital region", Int J Gynecol Pathol, 16, pp.325~334 (1997)
- Calonje E, "Superficial angiomyxoma: clinicopathologic analysis of a series of distinctive but poorly recognized cutaneous tumors with tendency for recurrence", Am J Surg Pathol, 23, pp.910~917 (1999)
- 김태희, "폐경이행기 생식기 비호발 부위에 발생한 섬유상피성 용종", 대한폐경학회지, 17(2), pp.110~113 (2011), 대한폐경학회[DOI]
- Nucci MR, "Vulvovaginal soft tissue tumours:update and review", Histopathology, 36, pp.97~108 (2000)
- Kim HS, "Giant superficial angiomyxoma of the vulva: a case report and review of the literature", J Cutan Pathol, 37, pp.672~677 (2010)
- Metin A, "Aggressive angiomyxoma of the vulva: a case report and review of the literature", Aegean Pathol J, 3, pp.1~4 (2006)
- Kura MM, "Aggressive angiomyxoma of the vulva: An uncommon entity", Indian Dermatol Online J, 3, pp.128~130 (2012)
- Blandamura S, "Aggressive angiomyxoma: a second case of metastasis with patient's death", Hum Pathol, 34, pp.1072~1074 (2003)
- Fetsch JF, "Aggressive angiomyxoma: a clinicopathologic study of 29 female patients", Cancer, 78, pp.79~90 (1996)