외음부에서 발생한 공격성 혈관점액종 1예
A case of aggressive angiomyxoma of the vulva
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공격성 혈관점액종 (aggressive angiomyxoma)은 젊은 여성의 골반과 회음부에서 드물게 발생되는 연조직 종양으로 점액성 기질 내에 혈관조직과 산발적인 방추형 세포로 구성된다. 성장속도가 느리며 전이는 매우 드물지만, 부분적으로 주위 조직으로 침습하는 양상을 나타내고 침윤성 경계가 불분명하여 수술 후 국소적 재발이 빈번한 특성을 가진다. 일차적 치료로 외과적 인 충분한 종양의 완전절제이지만 완전한 절제가 이루어진 경우에도 국소재발을 초래할 수 있으며, 최근 성선분비자극호르 몬 유사체를 이용한 내과적인 치료도 시도되고 있다. 저자들은 바르톨린선 낭종으로 오인된 29세 여성의 외음부 우측에 발 생한 공격성 혈관점액종을 수술 후 재발방지를 위한 보조요법으로 성선분비자극호르몬 유사체를 3개월간 사용하였으며 이 후 재발의 징후는 관찰되지 않았다.
Abstract
Aggressive angiomyxoma is an uncommon soft-tissue neoplasm which affects the pelvis and genital organs of the young female predominantly. This tumor has a high tendency of local recurrence, but it usually does not develop metastasis. Although surgical excision with wide tumor-free margins may be necessary to obtain a complete cure, some of patients experience local recurrences. Many of the tumors are estrogen receptor (ER) and progesterone receptor (PR) positive and medical therapy with gonadotropin-releasing hormone (GnRH) agonists showed to be effective in a few cases. We present a case of 29-years-old women who has aggressive angiomyxoma which was misdiagnosed as bartholin duct cyst. She was treated by wide local excision with postoperative adjuvant GnRH agonist therapy for 3 months. She is now free of disease during 9 months of follow up. We have described this case with the brief of literature.
참고문헌 (19)
- Yalinkaya A, "Aggressive angiomyxoma of the female pelvis and the labium", Acta Obstet Gynecol Scand, 82, pp.298~301 (2003)
- Steeper TA, "Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm", Am J Surg Pathol, 7, pp.463~475 (1983)
- Behranwala KA, "Vulvar soft tissue tumors", Int J Gynecol Cancer, 14, pp.94~99 (2004)
- Hilgers RD, "Aggressive angiomyxoma of the vulva", Obstet Gynecol, 68(3), pp.60S~62S (1986)
- 양영민, "좌골직장와에 발생한 공격성 혈관점액종", 대한산부인과학회잡지, 46(8), pp.14~14 (2003), 대한산부인과학회
- Begin LR, "Aggressive angiomyxoma of pelvic soft parts: a clinicopathologic study of nine cases", Hum Pathol, 16, pp.621~628
- Silverman JS, "Comparison of angiomyofibroblastoma and aggressive angiomyxoma in both sexes: four cases composed of bimodal CD34 and factor XIIIa positive dendritic cell subsets", Pathol Res Pract, 93, pp.673~682 (1997)
- Velanovich V, "Superficial angiomyxoma presenting as a groin hernia in a male toddler", Am Surg, 62, pp.253~255 (1996)
- Chan YM, "Aggressive angiomyxoma in females: is radical resection the only option?", Acta Obstet Gynecol Scand, 79, pp.216~220 (2000)
- Fetsch JF, "Aggressive angiomyxoma: a clinicopathologic study of 29 female patients", Cancer, 78, pp.79~90 (1996)
- Nucci MR, "Vulvovaginal soft tissue tumours: update and review", Histopathology, 36, pp.97~108 (2000)
- Kazmierczak B, "Cytogenetic and molecular analysis of an aggressive angiomyxoma", Am J Pathol, 147, pp.580~585 (1995)
- Destian S, "Aggressive angiomyxoma: CT appearance", Am J Gastroenterol, 81, pp.711~713 (1986)
- Steiner E, "Perineal excision of a large angiomyxoma in a young woman following magnetic resonance and angiographic imaging", Gynecol Oncol, 82, pp.568~570 (2001)
- Jeyadevan NN, "Imaging features of aggressive angiomyxoma", Clin Radiol, 58, pp.157~162 (2003)
- Behranwala KA, "Aggressive angiomyxoma: a distint clinical entity", Eur J Surg Oncol, 29, pp.558~563 (2003)
- Yaghoobian J, "Ultrasound and computed tomographic findings in aggressive angiomyxoma of the uterine cervix", J Ultrasound Med, 6, pp.209~212 (1987)
- Shinohara N, "Medical management of recurrent aggressive angiomyxoma with gonadotropinreleasing hormone agonist", Int J Urol, 11, pp.432~435 (2004)
- Htwe M, "Hormone-dependent, aggressive angiomyxoma of the vulva", Obstet Gynecol, 86(4), pp.697~699 (1995)