본문 바로가기
KERD
논문KCI 등재

Association Between Self-Reported Sleep and Cognitive Function in Patients With Mild Cognitive Impairment

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Objectives: This study aimed to investigate the association between self-reported sleep and cognitive function in individuals with mild cognitive impairment (MCI) to understand potential implications for Alzheimer’s disease prevention.Methods: This retrospective cohort study included 80 patients with MCI and 70 controls. Participants completed standardized questionnaires to assess self-reported sleep quality (Korean version of the Pittsburgh Sleep Quality Index [PSQI-K]), daytime sleepiness (Epworth Sleepiness Scale [ESS]), and insomnia severity (Insomnia Severity Index [ISI]). Cognitive function was evaluated using the Seoul Neuropsychological Test and the Korean version of the Mini-Mental State Examination. The Korea Instrumental Activities of Daily Living Scale was used to assess instrumental activities of daily living. Correlation analyses examined the relationship between sleep-related parameters and cognitive function.Results: The results indicated no significant differences in PSQI-K and ESS scores between patients with MCI and the control group. Correlation analyses revealed that poorer sleep quality was associated with reduced frontal and executive functions in patients with MCI, particularly in tests such as Controlled Oral Word Association Test (supermarket, -0.311, <i>p</i><0.001) and Trail Making Test (TMT) B (0.232, <i>p</i><0.001). Additionally, daytime dysfunction was associated with poorer cognitive performance across language and executive domains (e.g., Korean Boston Naming Test: -0.290, <i>p</i><0.001; TMTA: 0.248, <i>p</i><0.001). In both groups, ISI scores were linked to cognitive functions, particularly in attention, phonemic fluency, and executive function (e.g., digit span, backward: -0.225, <i>p</i><0.01; TMTA: 0.327, <i>p</i><0.01).Conclusions: These findings suggest that sleep disturbances significantly impact cognitive function and daily living abilities in patients with MCI.

Abstract

Objectives: This study aimed to investigate the association between self-reported sleep and cognitive function in individuals with mild cognitive impairment (MCI) to understand potential implications for Alzheimer’s disease prevention.Methods: This retrospective cohort study included 80 patients with MCI and 70 controls. Participants completed standardized questionnaires to assess self-reported sleep quality (Korean version of the Pittsburgh Sleep Quality Index [PSQI-K]), daytime sleepiness (Epworth Sleepiness Scale [ESS]), and insomnia severity (Insomnia Severity Index [ISI]). Cognitive function was evaluated using the Seoul Neuropsychological Test and the Korean version of the Mini-Mental State Examination. The Korea Instrumental Activities of Daily Living Scale was used to assess instrumental activities of daily living. Correlation analyses examined the relationship between sleep-related parameters and cognitive function.Results: The results indicated no significant differences in PSQI-K and ESS scores between patients with MCI and the control group. Correlation analyses revealed that poorer sleep quality was associated with reduced frontal and executive functions in patients with MCI, particularly in tests such as Controlled Oral Word Association Test (supermarket, -0.311, <i>p</i><0.001) and Trail Making Test (TMT) B (0.232, <i>p</i><0.001). Additionally, daytime dysfunction was associated with poorer cognitive performance across language and executive domains (e.g., Korean Boston Naming Test: -0.290, <i>p</i><0.001; TMTA: 0.248, <i>p</i><0.001). In both groups, ISI scores were linked to cognitive functions, particularly in attention, phonemic fluency, and executive function (e.g., digit span, backward: -0.225, <i>p</i><0.01; TMTA: 0.327, <i>p</i><0.01).Conclusions: These findings suggest that sleep disturbances significantly impact cognitive function and daily living abilities in patients with MCI.

참고문헌 (32)

  1. Petersen RC, "Current concepts in mild cognitive impairment", Arch Neurol, 58, pp.1985~1992 (2001)[DOI]
  2. Chen Y, "Prediction models for conversion from mild cognitive impairment to Alzheimer’s disease : a systematic review and meta-analysis", Front Aging Neurosci, 14, pp.840386~ (2022)[DOI]
  3. da Silva RA, "Sleep disturbances and mild cognitive impairment : a review", Sleep Sci, 8, pp.36~41 (2015)[DOI]
  4. Jelicic M, "Subjective sleep problems in later life as predictors of cognitive decline. Report from the Maastricht ageing study(MAAS)", Int J Geriatr Psychiatry, 17, pp.73~77 (2002)[DOI]
  5. Beaulieu-Bonneau S, "Sleep disturbances in older adults with mild cognitive impairment", Int Psychogeriatr, 21, pp.654~666 (2009)[DOI]
  6. Robbins R, "Self-reported sleep duration and timing : a methodological review of event definitions, context, and timeframe of related questions", Sleep Epidemiol, 1, pp.100016~ (2021)[DOI]
  7. Keil SA, "Longitudinal sleep patterns and cognitive impairment in older adults", JAMA Netw Open, 6, pp.e2346006~ (2023)[DOI]
  8. De Lepeleire J, "The diagnostic value of IADL evaluation in the detection of dementia in general practice", Aging Ment Health, 8, pp.52~57 (2004)[DOI]
  9. Shin HY, "Sleep problems associated with behavioral and psychological symptoms as well as cognitive functions in Alzheimer’s disease", J Clin Neurol, 10, pp.203~209 (2014)[DOI]
  10. Lee HR, "Relationship of sleep quality and cognitive function in patients with mild cognitive impairment and subjective memory impairment", J Sleep Med, 17, pp.167~174 (2020)[DOI]
  11. Kim MS, "Relationship among the health state, daily living activities (ADL, IADL), sleep state, and depression among old people at elderly care facilities", J Korea Acad Ind Coop Soc, 16, pp.2609~2619 (2015)[DOI]
  12. Kang SJ, "The reliability and validity of the Korean Instrumental Activities of Daily Living (K-IADL)", J Korean Neurol Assoc, 20, pp.8~14 (2002)
  13. Sohn SI, "The reliability and validity of the Korean version of the Pittsburgh Sleep Quality Index", Sleep Breath, (16), pp.803~812 (2012)[DOI]
  14. Cho YW, "The reliability and validity of the Korean version of the Epworth sleepiness scale", Sleep Breath, 15, pp.377~384 (2011)[DOI]
  15. Morin CM, "Insomnia : psychological assessment and management" (1993), Guilford Press
  16. Kang Y, "Seoul neuropsychological screening battery (SNSB)" (2003), Human Brain Research & Consulting Co.
  17. Raven F, "The role of sleep in regulating structural plasticity and synaptic strength : implications for memory and cognitive function", Sleep Med Rev, 39, pp.3~11 (2018)[DOI]
  18. Gao F, "Sleep disturbance is associated with mild cognitive impairment : a community population-based cross-sectional study", BMC Public Health, 22, pp.2000~ (2022)[DOI]
  19. Kang SH, "Subjective memory complaints in an elderly population with poor sleep quality", Aging Ment Health, 21, pp.532~536 (2017)[DOI]
  20. DiNapoli EA, "Subjective-objective sleep discrepancy in older adults with MCI and subsyndromal depression", J Geriatr Psychiatry Neurol, 30, pp.316~323 (2017)[DOI]
  21. Casagrande M, "Sleep quality and aging : a systematic review on healthy older people, mild cognitive impairment and Alzheimer’s disease", Int J Environ Res Public Health, 19, pp.8457~ (2022)[DOI]
  22. Nebes RD, "Self-reported sleep quality predicts poor cognitive performance in healthy older adults", J Gerontol B Psychol Sci Soc Sci, 64, pp.180~187 (2009)[DOI]
  23. Lo JC, "Self-reported sleep duration and cognitive performance in older adults : a systematic review and meta-analysis", Sleep Med, 17, pp.87~98 (2016)[DOI]
  24. Sexton CE, "Poor sleep quality is associated with increased cortical atrophy in communitydwelling adults", Neurology, 83, pp.967~973 (2014)[DOI]
  25. Altena E, "Reduced orbitofrontal and parietal gray matter in chronic insomnia : a voxel-based morphometric study", Biol Psychiatry, 67, pp.182~185 (2010)[DOI]
  26. Blattner MS, "Increased cerebrospinal fluid amyloid-β during sleep deprivation in healthy middleaged adults is not due to stress or circadian disruption", J Alzheimers Dis, 75, pp.471~482 (2020)[DOI]
  27. Hirotsu C, "Interactions between sleep, stress, and metabolism : from physiological to pathological conditions", Sleep Sci, 8, pp.143~152 (2015)[DOI]
  28. Jaussent I, "Excessive sleepiness is predictive of cognitive decline in the elderly", Sleep, 35, pp.1201~1207 (2012)[DOI]
  29. Stern AL, "Wake-active neurons across aging and neurodegeneration : a potential role for sleep disturbances in promoting disease", SpringerPlus, 4, pp.25~ (2015)[DOI]
  30. Altiok M, "Relationship between activities of daily living, sleep and depression among the aged living at home", Pak J Med Sci, 28, pp.162~166 (2012)
  31. Kwon AM, "Relation between health-related quality of life and sleep quality with adjustment for comorbidity among the Korean elderly : mixed-effects model with a 6-year follow-up study", Asia Pac J Public Health, 28, pp.271~279 (2016)[DOI]
  32. Yang S, "The relationship between sleep status and activity of daily living : based on China Hainan centenarians cohort study", BMC Geriatr, 23, pp.796~ (2023)[DOI]

관련 논문AI추천

이 간행물의 다른 논문 (8건)