본문 바로가기
KERD
논문KCI 등재

Chemotaxonomic Significance of Oregonin in Alnus japonica Native to Baekdudaegan Mountain Range in Korea

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Alnus japonica is indigenous to korea and usually grows in wet lowlands and damp regions in the mountains. Oregonin, is known as a representative compound of the diarylheptanoid mainly found in Alnus species and has been reported to have anti-inflammatory and antioxidant effects. In this experiment, we conducted a study on the presence of orogonin in the native Alnus japonica from the Baekdudaegan mountain range in Korea. We collected a total of 30 samples from Chuncheon, Yangyang, and Jeongseon and conducted experiments. In the HPLC analysis, we confirmed that oregonin was detected in all samples. After the quantitative analysis, samples with the highest content from each region were selected and LC-MS/MS experiments were performed. As a result, the same molecular weight as oregonin, 477.2 m/z, was confirmed in all samples.

Abstract

Alnus japonica is indigenous to korea and usually grows in wet lowlands and damp regions in the mountains. Oregonin, is known as a representative compound of the diarylheptanoid mainly found in Alnus species and has been reported to have anti-inflammatory and antioxidant effects. In this experiment, we conducted a study on the presence of orogonin in the native Alnus japonica from the Baekdudaegan mountain range in Korea. We collected a total of 30 samples from Chuncheon, Yangyang, and Jeongseon and conducted experiments. In the HPLC analysis, we confirmed that oregonin was detected in all samples. After the quantitative analysis, samples with the highest content from each region were selected and LC-MS/MS experiments were performed. As a result, the same molecular weight as oregonin, 477.2 m/z, was confirmed in all samples.

참고문헌 (20)

  1. An SW, "Comparison of hepatic detoxification activity and reducing serum alcohol concentration of Hovenia dulsis THUNB and Alnus japonica Steud", Korean J Med Crop Sci, 7, pp.263~268 (1999)
  2. Chi JH, "Ameliorative effect of Alnus japonica ethanol extract on colitis through the inhibition of inflammatory responses and attenuation of intestinal barrier disruption in vivo and in vitro", Biomed Pharmacother, 108, pp.1767~1774 (2018)
  3. Choi SE, "Effect of topical application and intraperitoneal injection of oregonin on atopic dermatitis in NC", Nga mice, 2010, pp.19, e37~e43
  4. Choi SE, "Effect of Alnus japonica extract on a model of atopic dermatitis in NC", Nga mice, 2011, pp.136, 406~413
  5. Choi SE, "Chemotaxonomic significance of oregonin in Alnus species", Asian J Chem, 25, pp.6989~6990 (2013)
  6. Han JM, "Effect of 5-O-methylhirsutanonol on nuclear factor-kappaB-dependent production of NO and expression of iNOS in lipopolysaccharide-induced RAW264. 7 cells", J Agric Food Chem, 56, pp.92~98 (2008)
  7. Kim HJ, "New diarylheptanoid from the barks of Alnus japonica Steudel", Chin Chem Lett, 16, pp.1337~1340 (2005)
  8. Kim HJ, "Nitric oxide and prostaglandin E2 synthesis inhibitory activities of diarylheptanoids from the barks of Alnus japonica steudel", Arch Pharm Res, 28, pp.177~179 (2005)
  9. Kuroyanagi M, "New diarylheptanoids from Alnus japonica and their antioxidative activity", Chem Pharm Bull(Tokyo), 53, pp.1519~1523 (2005)
  10. Lee H, "Extract of Alnus japonica prevents dexamethasone-induced muscle atrophy in mice", J Funct Foods, 101, pp.105419~ (2023)
  11. Lee MW, "Dimeric ellagitannins from Alnus japonica", Phytochemistry, 31, pp.2835~2839 (1992)
  12. Lee SJ, "Korea folk medicine" (1966), Seoul National University Publishing Center Press
  13. Na CS, "Effect of hot water extract of Alnus japonica Steud on the experimentally-induced acute gastritis and peptic ulcers in rats", Korean J Pharmacogn, 43, pp.72~78 (2012)
  14. Nomura M, "Biarylheptanoids and other constituents from wood of Alnus japonica", Phytochemistry, 20, pp.1097~1104 (1981)
  15. Ren X, "The genus Alnus, a comprehensive outline of its chemical constituents and biological activities", Molecules, 22, pp.1383~ (2017)
  16. Sati SC, "Bioactive constituents and medicinal importance of genus Alnus", Pharmacogn Rev, 5, pp.174~183 (2011)
  17. Sung SH, "Anti-adipogenic activity of a new cyclic diarylheptanoid isolated from Alnus japonica on 3T3-L1 cells via modulation of PPARγ, C", EBPα and SREBP1c signaling, 2015, pp.25, 4648~4651
  18. Tung NH, "Anti-influenza diarylheptanoids from the bark of Alnus japonica", Bioorg Med Chem Lett, 20, pp.1000~1003 (2010)
  19. Uto T, "Antiproliferative and pro-apoptotic activity of diarylheptanoids isolated from the bark of Alnus japonica in human leukemia cell lines", Am J Chin Med, 43, pp.757~767 (2015)
  20. Wada H, "Three new diarylheptanoid glycosides from Alnus japonica", Chem Pharm Bull, 46, pp.1054~1055 (1998)

관련 논문AI추천

Chemotaxonomic Significance of Oregonin in Alnus Species Native to South America, North Africa, Asia권예은, 김민석, 김태희, 안다현, 이현서, 장현두, 정은주, 최선은, Cha In Park, Chan Ho Lee, Hee Kyu Kim산림과학연구소 · Journal of forest and environmental science2025 · 제41권 제2호Chemotaxonomic Significance of Taxifolin-3-O-Arabinopyranoside in Rhododendron Species Native to Korea권예은, 김민석, 김진규, 김태희, 김희규, 박선민, 박세영, 배영수, 정영환, 최선은, CHEONG EUN JU, Chun Gong, Wei Gao, Yeon Ho Ham, Yi-Chang He산림과학연구소 · Journal of forest and environmental science2022 · 제38권 제3호Chemotaxonomic Significance of Taxifolin-3-O-arabinopyranoside in Vietnamese Rhododendron genus권예은, 김민석, 김태희, 김희규, 안다현, 장태영, 장현두, 정은주, 최선은, Hyun Seo Lee, Jin Kyu Kim, Jun Gyu Paek, Se Jung Bang산림과학연구소 · Journal of forest and environmental science2025 · 제41권 제3호Comparison of Anti-oxidant and Anti-inflammatory Activities of Methanolic Extracts Obtained from Different Parts of Cotoneaster wilsonii Nakai김명조, 김희규, 박주희, 유남호, 이찬옥한국약용작물학회 · 한국약용작물학회지2019 · 제27권 제3호Chemotaxonomic Significance of Taxifolin-3-O-arabinopyranoside in Chinese Rhododendron genus최선은, Chan Ho Lee, Hyeon Du Jang, Min Seok Kim, Sun Min Park, Tae Hee Kim, Ye Eun Kwon, Ye Ji Kim산림과학연구소 · Journal of forest and environmental science2024 · 제40권 제2호Constituents and their DPPH Scavenging Activities from the Leaves of Alnus hirsuta (Spach) Rupr.배기환, Phuong Thien Thuong, Tran Manh Hung, WenYi Jin, YingHui Dai, Zheng Cui한국약용작물학회 · 한국약용작물학회지2005 · 제13권 제2호

이 간행물의 다른 논문 (7건)