Chemotaxonomic Significance of Taxifolin-3-O-Arabinopyranoside in Rhododendron Species Native to Korea
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초록
Genus of Rhododendron has been used in traditional medicine since ancient times and is known to be effective in immune function, inflammation, and cold symptoms. And the reason for this activity is the flavanonol type among flavonoids in the genus of Rhododendron. Among the flavanonol types, Taxifolin-3-O-arabinopyranoside was isolated from the root of native R. mucronulatum in Korea, and the structure was finally identified through HPLC, LC-MS/MS, 1 H-NMR, and 13 C-NMR. Taxifolin-3-O-arabinopyranoside is a compound mainly found in R. mucronulatum, a representative species of the genus of Rhododendron, and exhibits antioxidant, anti-inflammatory, and anti-atopic activities. In this study, Taxifolin-3-O-arabinopyranoside was chemotaxonomic significant in 5 species of the genus Rhododendron native to Korea (R. mucronulatum, R. mucronulatum var. ciliatum, R. schlippenbachii, R. yedoense var. Poukhanense, R. japonicum for. Flavum). Compared with the existing literature, Taxifolin-3-O-arabinopyranoside was identified for the first time in 4 species of Rhododendron except for the R. mucronulatum.
Abstract
Genus of Rhododendron has been used in traditional medicine since ancient times and is known to be effective in immune function, inflammation, and cold symptoms. And the reason for this activity is the flavanonol type among flavonoids in the genus of Rhododendron. Among the flavanonol types, Taxifolin-3-O-arabinopyranoside was isolated from the root of native R. mucronulatum in Korea, and the structure was finally identified through HPLC, LC-MS/MS, 1 H-NMR, and 13 C-NMR. Taxifolin-3-O-arabinopyranoside is a compound mainly found in R. mucronulatum, a representative species of the genus of Rhododendron, and exhibits antioxidant, anti-inflammatory, and anti-atopic activities. In this study, Taxifolin-3-O-arabinopyranoside was chemotaxonomic significant in 5 species of the genus Rhododendron native to Korea (R. mucronulatum, R. mucronulatum var. ciliatum, R. schlippenbachii, R. yedoense var. Poukhanense, R. japonicum for. Flavum). Compared with the existing literature, Taxifolin-3-O-arabinopyranoside was identified for the first time in 4 species of Rhododendron except for the R. mucronulatum.
참고문헌 (24)
- Ahn JY, "Effect of taxifolin glycoside on atopic dermatitis-like skin lesions in NC", Nga mice, 2010, pp.24, 1071~1077
- Black P, "Seasonal variation of phenolic constituents and medicinal activities of Northern Labrador tea, Rhododendron tomentosum ssp. subarcticum, an Inuit and Cree First Nations traditional medicine", Planta Med, 77, pp.1655~1662 (2011)
- Choi SE, "Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by phenolic compounds from roots of Rhododendron mucronulatum", Phytother Res, 25, pp.1301~1305 (2011)
- Erdemoglu N, "Bioassay-guided isolation of anti-inflammatory and antinociceptive principles from a folk remedy, Rhododendron ponticum L. leaves", J Ethnopharmacol, 119, pp.172~178 (2008)
- Fu Y, "Far infrared-assisted extraction followed by MEKC for the simultaneous determination of flavones and phenolic acids in the leaves of Rhododendron mucronulatum Turcz", J Sep Sci, 35, pp.468~475 (2012)
- 장현욱, "가죽나무 에타놀 추출물 및 luteolin-7-O-glucoside의phospholipase A2 저해활성", 생약학회지, 38(3), pp.277~280 (2007), 한국생약학회
- Iwata N, "Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum", J Nat Prod, 67, pp.1106~1109 (2004)
- 장기욱, "만병초의 세포독성 성분", 약 학 회 지, 49(3), pp.244~248 (2005), 대한약학회
- Sung Je Jung, "Flavonoids from the Flower of Rhododendron yedoense var. Poukhanense and Their Antioxidant Activities", Archives of Pharmacal Research, 30(2), pp.146~150 (2007), 대한약학회
- Kang MJ, "Pep-1 peptide-conjugated elastic liposomal formulation of taxifolin glycoside for the treatment of atopic dermatitis in NC", Nga mice, 2010, pp.402, 198~204
- 김기범, "철쭉나무 (Rhododendron schlipenbachii) 잎의 Flavonoid성분", 생약학회지, 37(3), pp.177~183 (2006), 한국생약학회
- Myung-Hoe Kim, "Rhododendrin, an Analgesic", Anti-inflammatory Arylbutanoid Glycoside, from the Leaves of Rhododendron aureum, 2011, pp.34(6), 971~978[DOI]
- 김시은, "한국 자생 진달래속(Rhododendron) 3종 종자의 발아특성과 종간 차이", 화훼연구, 29(1), pp.18~28 (2021), 한국화훼학회
- 김태양, "진달래뿌리추출물과 이로부터 분리한 taxifolin-3-O-alpha-L-arabinopyranoside의 항노화 활성", 한국화장품미용학회지, 8(3), pp.339~344 (2018), 한국화장품미용학회
- Kim YJ, "Taxifolin glycoside inhibits dendritic cell responses stimulated by lipopolysaccharide and lipoteichoic acid", J Pharm Pharmacol, 60, pp.1465~1472 (2008)
- Checklist of Vascular Plants in Korea (Native Plants), "Korea National Arboretum", Korea National Arboretum of the Korea Forest Service, ~ (2021)
- Jin Hoon Lee, "The Chemical Constituents and their Antioxidant Activity of the Stem of Rhododendron mucronulatum", Natural Product Sciences, 11(2), pp.97~102 (2005), 한국생약학회
- 민준홍, "한국산 진달래과 식물에 관한 본초학적 연구", 대한본초학회지, 28(4), pp.41~48 (2013), 대한본초학회
- Ashish Paul, "Phenological Characteristics of Rhododendron Species in Temperate Mixed Broad-leaved Forests of Arunachal Himalaya, India", Journal of forest and environmental science, 34(6), pp.435~450 (2018), 산림과학연구소[DOI]
- Popescu R, "The genus Rhododendron: an ethnopharmacological and toxicological review", J Ethnopharmacol, 147, pp.42~62 (2013)
- Qiang Y, "Chemical constituents of plants from the genus Rhododendron", Chem Biodivers, 8, pp.792~815 (2011)
- Sancheti S, "Screening of Korean Medicinal Plant Extracts for Glucosidase Inhibitory Activities", Iran J Pharm Res, 10, pp.261~264 (2011)
- Usman A, "Isolation of Taxifolin from Trichilia Emetica Whole Seeds", Am Sci Res J Eng Technol Sci, 21, pp.77~82 (2016)
- Si Woong Yang, "Analysis of Total Phenolic, Flavonoid Contents, and Antioxidant Capacity Extract from Leaves of Selected Accessions of Two Wild Pear Species, Pyrus pyrifolia and P. ussuriensis", Journal of forest and environmental science, 37(3), pp.226~234 (2021), 산림과학연구소