Parathyroid Carcinoma: Outcome Analysis of 16 Cases from a Single Center
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: Parathyroid carcinoma is an extremely rare malignancy, but there is still a lack of understanding of the natural course and prognostic implications of this disease. In this study, we reviewed the clinicopathological characteristics of patients with parathyroid carcinoma treated at our institution. Methods: Patients with parathyroid carcinoma were included in this study. We reviewed the clinicopathological characteristics of patients with parathyroid carcinoma treated at our institution, and evaluated patient outcomes and prognostic factors. Results: A total of 16 patients with parathyroid carcinoma were included in this study. The median follow-up duration was 61.5 months (range, 7–215 months), and seven patients developed recurrence (7/16, 43.8%). Four patients had died from parathyroid carcinoma (4/16, 25.0%) at the time of the analysis. Increased serum intact parathyroid hormone (iPTH) level during follow-up was an independent risk factor for recurrence after making adjustments for multivariate analysis. Trends of increasing serum calcium and iPTH levels after surgery were associated with the development of recurrence. Conclusion: We observed a good survival rate after initial surgery for parathyroid carcinoma. However, the rate of recurrence was relatively high and early detection of recurrence is critical. Close monitoring during follow-up is necessary, and a serial check for serum calcium and iPTH level may prove useful. When steadily increasing serum calcium and iPTH results are observed, careful evaluation for recurrence is needed.
Abstract
Purpose: Parathyroid carcinoma is an extremely rare malignancy, but there is still a lack of understanding of the natural course and prognostic implications of this disease. In this study, we reviewed the clinicopathological characteristics of patients with parathyroid carcinoma treated at our institution. Methods: Patients with parathyroid carcinoma were included in this study. We reviewed the clinicopathological characteristics of patients with parathyroid carcinoma treated at our institution, and evaluated patient outcomes and prognostic factors. Results: A total of 16 patients with parathyroid carcinoma were included in this study. The median follow-up duration was 61.5 months (range, 7–215 months), and seven patients developed recurrence (7/16, 43.8%). Four patients had died from parathyroid carcinoma (4/16, 25.0%) at the time of the analysis. Increased serum intact parathyroid hormone (iPTH) level during follow-up was an independent risk factor for recurrence after making adjustments for multivariate analysis. Trends of increasing serum calcium and iPTH levels after surgery were associated with the development of recurrence. Conclusion: We observed a good survival rate after initial surgery for parathyroid carcinoma. However, the rate of recurrence was relatively high and early detection of recurrence is critical. Close monitoring during follow-up is necessary, and a serial check for serum calcium and iPTH level may prove useful. When steadily increasing serum calcium and iPTH results are observed, careful evaluation for recurrence is needed.
참고문헌 (19)
- Shane E, "Clinical review 122 : parathyroid carcinoma", J Clin Endocrinol Metab, 86, pp.485~493 (2001)
- Gatta G, "Burden and centralised treatment in Europe of rare tumours : results of RARECAREnet-a population-based study", Lancet Oncol, 18, pp.1022~1039 (2017)
- Al-Kurd A, "Parathyroid carcinoma", Surg Oncol, 23, pp.107~114 (2014)
- Lee PK, "Trends in the incidence and treatment of parathyroid cancer in the United States", Cancer, 109, pp.1736~1741 (2007)
- Iihara M, "Functional parathyroid carcinoma : long-term treatment outcome and risk factor analysis", Surgery, 142, pp.936~943 (2007)
- Busaidy NL, "Parathyroid carcinoma : a 22-year experience", Head Neck, 26, pp.716~726 (2004)
- Erovic BM, "Parathyroid cancer : outcome analysis of 16 patients treated at the Princess Margaret Hospital", Head Neck, 35, pp.35~39 (2013)
- Harari A, "Parathyroid carcinoma : a 43-year outcome and survival analysis", J Clin Endocrinol Metab, 96, pp.3679~3686 (2011)
- Schaapveld M, "Incidence and prognosis of parathyroid gland carcinoma : a population-based study in The Netherlands estimating the preoperative diagnosis", Am J Surg, 202, pp.590~597 (2011)
- Kleinpeter KP, "Is parathyroid carcinoma indeed a lethal disease", Ann Surg Oncol, 12, pp.260~266 (2005)
- Asare EA, "Parathyroid carcinoma : an update on treatment outcomes and prognostic factors from the National Cancer Data Base(NCDB)", Ann Surg Oncol, 22, pp.3990~3995 (2015)
- Talat N, "Clinical presentation, staging and long-term evolution of parathyroid cancer", Ann Surg Oncol, 17, pp.2156~2174 (2010)
- Iacobone M, "Up-to-date on parathyroid carcinoma : analysis of an experience of 19cases", J Surg Oncol, 88, pp.223~228 (2004)
- Villar-del-Moral J, "Prognostic factors and staging systems in parathyroid cancer : a multicenter cohort study", Surgery, 156, pp.1132~1144 (2014)
- Kebebew E, "Localization and reoperation results for persistent and recurrent parathyroid carcinoma", Arch Surg, 136, pp.878~885 (2001)
- Quaglino F, "Parathyroid carcinoma : an up-todate retrospective multicentric analysis", Int J Endocrinol, 2020, pp.7048185~ (2020)
- Robert JH, "Primary hyperparathyroidism : can parathyroid carcinoma be anticipated on clinical and biochemical grounds? Report of nine cases and review of the literature", Ann Surg Oncol, 12, pp.526~532 (2005)
- Lee YS, "Parathyroid carcinoma : a 16-year experience in a single institution", Endocr J, 57, pp.493~497 (2010)
- 석재연, "Parathyroid Cancer: Comparison with Benign Hyperparathyroidism", Journal of Endocrine Surgery, 19(2), pp.35~44 (2019), 대한내분비외과학회