기니픽 알레르기 모델에서 Leukotriene 길항제의 효과

Abstract

Background and Objectives：The leukotriene (LT) receptor antagonist is subject to an on-going study of alergic rhinitis, nasal polyposis and chronic paranasal sinusitis. This study was designed to evaluate the change of nasal patency and morphological changes by assesing the role of 4-oxo-8-benzopyren-hemihydrate (ONO-1078, BH), a cysLT1 receptor antagonist to treatment of allergic rhinitis. Materials and Method：Sixty-five guinea pigs (GPs) were divided into 3 groups：μg DNP-As containing 1 mL Al (OH)3 and booster injections were given intraperitonealy 2, 4 and 6 weeks after the initial imunization. Measurements of nasal volume were made by acoustic rhinometry. Also transmission electron microscopy was performed to investigate ultrastructural changes of the nasal mucosal membrane in the LTD4 administrated GPs and the BH treated GPs. Results：and 6 hours after instillation of LTD4 in nonsensitized guinea pigs (GPs). However, neither nonsensitized nor sensitized GPs with systemic administration of BH showed any changes in nasal patency. Many neutrophils and eosinophils were sen in periva-scular space after local administration of LTD4 in control GPs. However there are no eosinophil infiltration into the subepithelial space in BH treated GPs in both nonsensitized and sensitized group. Conclusion：The results suggest that BH might be a potent LT receptor antagonist in the alergic model of GPs, which reduces nasal blockage and block chemotaxis of eosinophils to the (Korean J Otolaryngol 2003 ;46 :1028-34)