Pimecrolimus가 마우스 천식 모델에서 기도 염증과 과민성에 미치는 영향
The Effectiveness of Pimecrolimus in Airway Inflammation and Bronchial Hyperresponsiveness in Murine Asthma Model
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Abstract
Background: Pimecrolimus is effective in atopic dermatitis and psoriasis. However, little is known about the effectiveness of pimecrolimus in allergic asthma. Objective: The aim of this study was to assess the effectiveness of pimecrolimus in bronchial hyperresponsiveness and airway inflammation in murine asthma model. Method: Female BALB/c mice fed with a standard chow incorporated with pimecrolimus for one week before either sensitization (group A, n=10) or allergen challenge (group B, n=10). Enhanced pause (Penh), methacholine bronchoprovocation test and bronchoalveolar lavage fluid (BALF)analyses were performed. Result: The developments of airway narrowing and bronchial hyperresponsiveness induced by allergen challenge were suppressed in group B. The percentage of eosinophils and the levels of interleukin (IL)-4 and IL-5 in the BALF were also decreased in group B. Conclusion: Pimecrolimus given before allergen challenge suppresses the developments of airway inflammation and bronchial hyperresponsiveness in murine asthma model.
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