비용과 -308, -238 종양괴사인자-α 촉진자 다형태의 연관성
Association Between Nasal Polyp and -308, -238 Tumor Necrosis Factor-α Polymorphism
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Abstract
Background and Objectives：Nasal polyps are the most comon mas lesion of the nasal cavity and it occurs on both infe-ctious and noninfectious basis, and especialy because genetic etiology is suspected in the development of nasal polyp. Tumor necrosis factor-α(TNF-α) is a pivotal cytokine in inflamatory and infectious diseases, and increased tissue TNF-α levels have been observed in the inflammatory type of nasal polyp. It has been known that several TNF-α gene polymorphisms in a promoter region are related to TNF-α production. Among them, the G to A substitution at the position 308 (TNF-α 308A) and at the position 238 (TNF-α 238A) in the TNF-α promoter are associated with the high or low production of TNF-αwe investigated the association between with TNF-α promoter polymorphism and nasal polyps. Subjects and Methods：This study included 104 patients with polyp asociated chronic sinusitis and 104 healthy controls. TNF-α promoter genotype was screned by PCR-restriction fragment length polymorphism (PCR-RFLP). Results：In the nasal polyp associated chronic sinusitis, the frequency of TNF-α 308A was higher than those of healthy controls (OR, 1.739；95% CI, 0.653- 4.63 ). But there was no statistical significance between distribution of TNF-α gene polymorphism and nasal polyps. Frequency of TNF-α 238A was higher in nasal polyp than in healthy controls, but no significant differences were found. We concluded that TNF-α polymorphism did not show genetic predisposition with regard to nasal polyp in Korean patients.
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