귀에 존재하는 내인성 성체줄기세포
Endogenous Stem Cells in the Ear
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Basically stem cells have characteristics of multi-potency, differentiation into multiple tissue types, and self-renew through proliferation. Recent advances in stem cell biology can make identifying the stem-cell like cells in various mammalian tissues. Stem cells in various tissues can restore damaged tissue. Stem cells from the adult nervous system proliferate to form clonal floating colonies called spheres in vitro, and recent studies have demonstrated sphere formation by cells in the tympanic membrane, vestibular system, spiral ganglion, and partly in the organ of Corti. The presence of stem cells in the ear raises the possibilities for the regeneration of the tympanic membrane & inner ear hair cells & neurons. But the gradual loss of stem cells postnatally in the organ of Corti may correlate with the loss of regenerative capacity and limited hearing restoration. Future strategies using endogenous stem cells in the ear can be the another treatment modality for the patients with intractable inner ear diseases.
Abstract
Basically stem cells have characteristics of multi-potency, differentiation into multiple tissue types, and self-renew through proliferation. Recent advances in stem cell biology can make identifying the stem-cell like cells in various mammalian tissues. Stem cells in various tissues can restore damaged tissue. Stem cells from the adult nervous system proliferate to form clonal floating colonies called spheres in vitro, and recent studies have demonstrated sphere formation by cells in the tympanic membrane, vestibular system, spiral ganglion, and partly in the organ of Corti. The presence of stem cells in the ear raises the possibilities for the regeneration of the tympanic membrane & inner ear hair cells & neurons. But the gradual loss of stem cells postnatally in the organ of Corti may correlate with the loss of regenerative capacity and limited hearing restoration. Future strategies using endogenous stem cells in the ear can be the another treatment modality for the patients with intractable inner ear diseases.
참고문헌 (24)
- Martinez-Monedero R, "The potential role of endogenous stem cells in regeneration of the inner ear", Hear Res, 227(1-2), pp.48~52 (2007)
- Okano T, "Stem cell therapy for the inner ear: recent advances and future directions", Trends Amplif, 16(1), pp.4~18 (2012)
- Reynolds BA, "Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system", Science, 255(5052), pp.1707~1710 (1992)
- Ma Y, "Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application", Acta Otolaryngol, 122(6), pp.586~599 (2002)
- Rahman A, "Healing time, long-term result and effects of stem cell treatment in acute tympanic membrane perforation", Int J Pediatr Otorhinolaryngol, 71(7), pp.1129~1137 (2007)
- Wang WQ, "Epidermal stem cells in the tympanic membrane", Zhonghua Er Bi Yan Hou Ke Za Zhi, 39(12), pp.712~716 (2004)
- Knutsson J, "Localization of progenitor", stem cells in the human tympanic membrane, 2011, pp.16(4), 263~269
- 박경호, "기니아 피그 고막에서 성체신경줄기세포의 분리 배양", 대한이비인후과학회지 두경부외과학, 51(1), pp.28~32 (2008), 대한이비인후과학회
- Warchol ME, "Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans", Science, 259(5101), pp.1619~1622 (1993)
- Forge A, "Ultrastructural evidence for hair cell regeneration in the mammalian inner ear", Science, 259(5101), pp.1616~1619 (1993)
- Li H, "Pluripotent stem cells from the adult mouse inner ear", Nat Med, 9(10), pp.1293~1299 (2003)
- Park KH, "Nestin Expression in Proliferating Cells of Cultured Human Vestibular Organs", Int Adv Otol, 5(1), pp.6~10 (2009)
- Taupin P, "BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation", Brain Res Rev, 53(1), pp.198~214 (2007)
- Lendahl U, "CNS stem cells express a new class of intermediate filament protein", Cell, 60(4), pp.585~595 (1990)
- Wislet-Gendebien S, "Plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype", Stem Cells, 23(3), pp.392~402 (2005)
- Malgrange B, "Proliferative generation of mammalian auditory hair cells in culture", Mech Dev, 112(1-2), pp.79~88 (2002)
- Wang Z, "Characterization of proliferating cells from newborn mouse cochleae", Neuroreport, 17(8), pp.767~771 (2006)
- Lou X, "Multipotent stem cells from the young rat inner ear", Neurosci Lett, 416(1), pp.28~33 (2007)
- Oshima K, "Differential distribution of stem cells in the auditory and vestibular organs of the inner ear", J Assoc Res Otolaryngol, 8(1), pp.18~31 (2007)
- Lee DH, "The past, present and future of cochlear stem cell research: we have no conclusion but now we have hope", Korean J Audiol, 14(3), pp.163~172 (2010)
- Rask-Andersen H, "Regeneration of human auditory nerve. In vitro", in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion, 2005, pp.203(1-2), 180~191
- 최혁기, "기니픽 와우신경절에서 성체신경줄기세포의 분리 배양", 조직공학과 재생의학, 6(4), pp.938~941 (2009), 한국조직공학과 재생의학회
- 오정훈, "난청 동물모델에서 신경성장인자에 의한 청력회복과 나선 신경절재생에 관한 연구", 조직공학과 재생의학, 5(4), pp.849~854 (2008), 한국조직공학과 재생의학회
- Choi MY, "Hearing restoration in a deaf animal model with intravenous transplantation of mesenchymal stem cells derived from human umbilical cord blood", Biochem Biophys Res Commun, 427(3), pp.629~636 (2012)